| Chain sequence(s) |
A: SCSALPSSLTLKSNKKLVDLFTHFNGKKVTTKEEFACRQAELSELIQRYELGTLPGRPSTLTASFSGNTLTINCGENGKSISFTVTITYPSSGTAPYPAIIGFGGGSLPQPDGVALINFNNDEIAKQTSSSSRGQGKFYDLYGSSHSAGAMTAWAWGVSRVIDALELTPAANIDTTKIGVTGCSRNGKGALVAGAFEKRIVLTIPQESGMGGSACWRISDYEKSQGKNIQTASEIVGEYPWFSTTFNSYVNKVDLLPFDHHSLAALIAPRGLLVIDNVIDWLGPESCVGCMSAARRAWQALGVPDNMGYSQIGSHAHCAFPSSQQADLTAFVNKFLLGQSVNTAIFRSDFSANESQWIDWTTPTLS
input PDB |
| Selected Chain(s) | A |
| Distance of aggregation | 10 Å |
| FoldX usage | Yes |
| Dynamic mode | No |
| Automated mutations | No |
| Downloads | Download all the data |
| Simulation log |
[INFO] Logger: Verbosity set to: 2 - [INFO] (00:00:02)
[WARNING] runJob: Working directory already exists (possibly overwriting previous results -ow
to prevent this behavior) (00:00:02)
[INFO] runJob: Starting aggrescan3d job on: input.pdb with A chain(s) selected (00:00:02)
[INFO] runJob: Creating pdb object from: input.pdb (00:00:02)
[INFO] FoldX: Starting FoldX energy minimalization (00:00:02)
[INFO] Analysis: Starting Aggrescan3D on folded.pdb (00:07:21)
[INFO] Main: Simulation completed successfully. (00:07:25)
|
The table below lists A3D score for protein residues. Residues with A3D score > 0.0000 are marked by yellow rows.
| residue index | residue name | chain | Aggrescan3D score | mutation |
|---|---|---|---|---|
| residue index | residue name | chain | Aggrescan3D score | |
| 1 | S | A | -0.2714 | |
| 2 | C | A | 0.0378 | |
| 3 | S | A | -0.1706 | |
| 4 | A | A | -0.0710 | |
| 5 | L | A | -0.2361 | |
| 6 | P | A | -0.3775 | |
| 7 | S | A | -0.3350 | |
| 8 | S | A | -0.2553 | |
| 9 | L | A | -0.1978 | |
| 10 | T | A | -0.2853 | |
| 11 | L | A | -0.4711 | |
| 12 | K | A | -1.7847 | |
| 13 | S | A | -1.6969 | |
| 14 | N | A | -1.8330 | |
| 15 | K | A | -2.5765 | |
| 16 | K | A | -2.2175 | |
| 17 | L | A | 0.0000 | |
| 18 | V | A | -0.6413 | |
| 19 | D | A | -0.7640 | |
| 20 | L | A | 0.0000 | |
| 21 | F | A | 0.0000 | |
| 22 | T | A | -1.5198 | |
| 23 | H | A | -1.4774 | |
| 24 | F | A | -0.6714 | |
| 25 | N | A | -1.9045 | |
| 26 | G | A | -2.1010 | |
| 27 | K | A | -2.9085 | |
| 28 | K | A | -2.7761 | |
| 29 | V | A | 0.0000 | |
| 30 | T | A | -1.3509 | |
| 31 | T | A | -1.6203 | |
| 32 | K | A | -2.3118 | |
| 33 | E | A | -2.5408 | |
| 34 | E | A | -1.9966 | |
| 35 | F | A | 0.0000 | |
| 36 | A | A | -1.0031 | |
| 37 | C | A | -0.6309 | |
| 38 | R | A | 0.0000 | |
| 39 | Q | A | -0.5418 | |
| 40 | A | A | -0.2996 | |
| 41 | E | A | -0.3792 | |
| 42 | L | A | 0.0000 | |
| 43 | S | A | -0.6889 | |
| 44 | E | A | -1.2087 | |
| 45 | L | A | 0.0000 | |
| 46 | I | A | 0.0000 | |
| 47 | Q | A | -0.7341 | |
| 48 | R | A | -0.7996 | |
| 49 | Y | A | -0.4543 | |
| 50 | E | A | 0.0000 | |
| 51 | L | A | 0.0000 | |
| 52 | G | A | 0.0000 | |
| 53 | T | A | -0.3515 | |
| 54 | L | A | -0.2399 | |
| 55 | P | A | -0.5367 | |
| 56 | G | A | -1.3374 | |
| 57 | R | A | -2.1116 | |
| 58 | P | A | 0.0000 | |
| 59 | S | A | -1.0579 | |
| 60 | T | A | -0.9245 | |
| 61 | L | A | -0.2462 | |
| 62 | T | A | 0.1091 | |
| 63 | A | A | 0.0075 | |
| 64 | S | A | 0.0486 | |
| 65 | F | A | -0.2408 | |
| 66 | S | A | -0.5677 | |
| 67 | G | A | -0.9281 | |
| 68 | N | A | -1.0793 | |
| 69 | T | A | -0.7140 | |
| 70 | L | A | 0.0000 | |
| 71 | T | A | -0.2853 | |
| 72 | I | A | 0.0000 | |
| 73 | N | A | -0.5548 | |
| 74 | C | A | 0.0000 | |
| 75 | G | A | -1.4962 | |
| 76 | E | A | -1.8900 | |
| 77 | N | A | -2.1911 | |
| 78 | G | A | -2.0469 | |
| 79 | K | A | -2.7947 | |
| 80 | S | A | -1.8555 | |
| 81 | I | A | 0.0000 | |
| 82 | S | A | -0.4509 | |
| 83 | F | A | 0.0000 | |
| 84 | T | A | -0.5777 | |
| 85 | V | A | 0.0000 | |
| 86 | T | A | -0.7696 | |
| 87 | I | A | 0.0000 | |
| 88 | T | A | -0.2223 | |
| 89 | Y | A | -0.1750 | |
| 90 | P | A | -0.5871 | |
| 91 | S | A | -0.6411 | |
| 92 | S | A | -0.8595 | |
| 93 | G | A | -0.7829 | |
| 94 | T | A | -0.4510 | |
| 95 | A | A | -0.4678 | |
| 96 | P | A | -0.7799 | |
| 97 | Y | A | -0.2954 | |
| 98 | P | A | -0.2695 | |
| 99 | A | A | 0.0000 | |
| 100 | I | A | 0.0000 | |
| 101 | I | A | 0.0000 | |
| 102 | G | A | 0.0000 | |
| 103 | F | A | 0.0000 | |
| 104 | G | A | -1.4229 | |
| 105 | G | A | -1.0007 | |
| 106 | G | A | -0.5438 | |
| 107 | S | A | -0.2174 | |
| 108 | L | A | -0.1220 | |
| 109 | P | A | -0.6568 | |
| 110 | Q | A | -0.9570 | |
| 111 | P | A | -1.2945 | |
| 112 | D | A | -2.0064 | |
| 113 | G | A | 0.0000 | |
| 114 | V | A | 0.0000 | |
| 115 | A | A | 0.0000 | |
| 116 | L | A | -0.0911 | |
| 117 | I | A | 0.0000 | |
| 118 | N | A | -1.3419 | |
| 119 | F | A | 0.0000 | |
| 120 | N | A | -2.2956 | |
| 121 | N | A | 0.0000 | |
| 122 | D | A | -2.2735 | |
| 123 | E | A | -2.2335 | |
| 124 | I | A | 0.0000 | |
| 125 | A | A | 0.0000 | |
| 126 | K | A | -2.0734 | |
| 127 | Q | A | 0.0000 | |
| 128 | T | A | -0.6282 | |
| 129 | S | A | -0.6445 | |
| 130 | S | A | -0.7619 | |
| 131 | S | A | -0.8643 | |
| 132 | S | A | 0.0000 | |
| 133 | R | A | -1.5037 | |
| 134 | G | A | 0.0000 | |
| 135 | Q | A | -2.3684 | |
| 136 | G | A | -2.1415 | |
| 137 | K | A | -1.8934 | |
| 138 | F | A | 0.0000 | |
| 139 | Y | A | 0.0000 | |
| 140 | D | A | -2.5612 | |
| 141 | L | A | 0.0000 | |
| 142 | Y | A | -1.1008 | |
| 143 | G | A | -1.2592 | |
| 144 | S | A | -1.3101 | |
| 145 | S | A | -0.7172 | |
| 146 | H | A | -0.5250 | |
| 147 | S | A | -0.3771 | |
| 148 | A | A | 0.0000 | |
| 149 | G | A | 0.0000 | |
| 150 | A | A | 0.0000 | |
| 151 | M | A | 0.0000 | |
| 152 | T | A | 0.0000 | |
| 153 | A | A | 0.0000 | |
| 154 | W | A | 0.0000 | |
| 155 | A | A | 0.0000 | |
| 156 | W | A | 0.0000 | |
| 157 | G | A | 0.0000 | |
| 158 | V | A | 0.0000 | |
| 159 | S | A | 0.0000 | |
| 160 | R | A | 0.0000 | |
| 161 | V | A | 0.0000 | |
| 162 | I | A | 0.0000 | |
| 163 | D | A | 0.0000 | |
| 164 | A | A | 0.0000 | |
| 165 | L | A | 0.0000 | |
| 166 | E | A | -1.1946 | |
| 167 | L | A | 0.6010 | |
| 168 | T | A | 0.0000 | |
| 169 | P | A | -0.5889 | |
| 170 | A | A | -0.3180 | |
| 171 | A | A | 0.0000 | |
| 172 | N | A | -0.8790 | |
| 173 | I | A | 0.0000 | |
| 174 | D | A | -1.0518 | |
| 175 | T | A | -1.0423 | |
| 176 | T | A | -0.6764 | |
| 177 | K | A | -0.5312 | |
| 178 | I | A | 0.0000 | |
| 179 | G | A | 0.0000 | |
| 180 | V | A | 0.0000 | |
| 181 | T | A | 0.0000 | |
| 182 | G | A | 0.0000 | |
| 183 | C | A | 0.0000 | |
| 184 | S | A | -0.5365 | |
| 185 | R | A | -0.7921 | |
| 186 | N | A | -0.8013 | |
| 187 | G | A | 0.0000 | |
| 188 | K | A | 0.0000 | |
| 189 | G | A | 0.0000 | |
| 190 | A | A | 0.0000 | |
| 191 | L | A | 0.0000 | |
| 192 | V | A | 0.0000 | |
| 193 | A | A | 0.0000 | |
| 194 | G | A | 0.0000 | |
| 195 | A | A | 0.0000 | |
| 196 | F | A | 0.0000 | |
| 197 | E | A | 0.0000 | |
| 198 | K | A | -1.9540 | |
| 199 | R | A | -1.4282 | |
| 200 | I | A | 0.0000 | |
| 201 | V | A | -0.4231 | |
| 202 | L | A | 0.0000 | |
| 203 | T | A | 0.0000 | |
| 204 | I | A | 0.0000 | |
| 205 | P | A | 0.0000 | |
| 206 | Q | A | 0.0000 | |
| 207 | E | A | 0.0000 | |
| 208 | S | A | 0.0000 | |
| 209 | G | A | 0.0000 | |
| 210 | M | A | 0.0000 | |
| 211 | G | A | 0.0000 | |
| 212 | G | A | 0.0000 | |
| 213 | S | A | 0.0000 | |
| 214 | A | A | 0.0000 | |
| 215 | C | A | 0.0000 | |
| 216 | W | A | 0.0000 | |
| 217 | R | A | 0.0000 | |
| 218 | I | A | 0.0000 | |
| 219 | S | A | 0.0000 | |
| 220 | D | A | -2.4650 | |
| 221 | Y | A | -1.3335 | |
| 222 | E | A | -1.8439 | |
| 223 | K | A | -2.3314 | |
| 224 | S | A | -1.8295 | |
| 225 | Q | A | -2.2380 | |
| 226 | G | A | -1.8839 | |
| 227 | K | A | -2.3865 | |
| 228 | N | A | -2.1414 | |
| 229 | I | A | 0.0000 | |
| 230 | Q | A | 0.0000 | |
| 231 | T | A | 0.0000 | |
| 232 | A | A | 0.0000 | |
| 233 | S | A | -1.5521 | |
| 234 | E | A | -1.1122 | |
| 235 | I | A | 0.0000 | |
| 236 | V | A | -0.6457 | |
| 237 | G | A | -1.0063 | |
| 238 | E | A | -0.8688 | |
| 239 | Y | A | -0.5822 | |
| 240 | P | A | 0.0000 | |
| 241 | W | A | 0.0000 | |
| 242 | F | A | 0.0000 | |
| 243 | S | A | 0.0000 | |
| 244 | T | A | -0.6208 | |
| 245 | T | A | -0.5792 | |
| 246 | F | A | 0.0000 | |
| 247 | N | A | -1.7082 | |
| 248 | S | A | -1.2286 | |
| 249 | Y | A | -1.1853 | |
| 250 | V | A | 0.0000 | |
| 251 | N | A | -2.5393 | |
| 252 | K | A | -2.6464 | |
| 253 | V | A | 0.0000 | |
| 254 | D | A | -1.9820 | |
| 255 | L | A | -1.1105 | |
| 256 | L | A | 0.0000 | |
| 257 | P | A | -0.1183 | |
| 258 | F | A | 0.0000 | |
| 259 | D | A | 0.0000 | |
| 260 | H | A | 0.0000 | |
| 261 | H | A | 0.0000 | |
| 262 | S | A | 0.0000 | |
| 263 | L | A | 0.0000 | |
| 264 | A | A | 0.0000 | |
| 265 | A | A | 0.0000 | |
| 266 | L | A | 0.0000 | |
| 267 | I | A | 0.0000 | |
| 268 | A | A | 0.0000 | |
| 269 | P | A | -0.6498 | |
| 270 | R | A | -0.5335 | |
| 271 | G | A | 0.0000 | |
| 272 | L | A | 0.0000 | |
| 273 | L | A | 0.0000 | |
| 274 | V | A | 0.0000 | |
| 275 | I | A | 0.0000 | |
| 276 | D | A | 0.0000 | |
| 277 | N | A | 0.0000 | |
| 278 | V | A | 0.4267 | |
| 279 | I | A | 0.1730 | |
| 280 | D | A | -0.9971 | |
| 281 | W | A | -0.2837 | |
| 282 | L | A | 0.0000 | |
| 283 | G | A | 0.0000 | |
| 284 | P | A | 0.0000 | |
| 285 | E | A | -0.6679 | |
| 286 | S | A | 0.0000 | |
| 287 | C | A | 0.0000 | |
| 288 | V | A | 0.0000 | |
| 289 | G | A | 0.0000 | |
| 290 | C | A | 0.0000 | |
| 291 | M | A | 0.0000 | |
| 292 | S | A | 0.0000 | |
| 293 | A | A | 0.0000 | |
| 294 | A | A | 0.0000 | |
| 295 | R | A | -0.9414 | |
| 296 | R | A | -0.9484 | |
| 297 | A | A | 0.0000 | |
| 298 | W | A | 0.0000 | |
| 299 | Q | A | -1.4626 | |
| 300 | A | A | 0.0000 | |
| 301 | L | A | 0.0000 | |
| 302 | G | A | -0.9206 | |
| 303 | V | A | -0.4735 | |
| 304 | P | A | -0.9749 | |
| 305 | D | A | -1.1734 | |
| 306 | N | A | -0.9161 | |
| 307 | M | A | 0.0000 | |
| 308 | G | A | 0.0000 | |
| 309 | Y | A | 0.0000 | |
| 310 | S | A | 0.0000 | |
| 311 | Q | A | 0.0000 | |
| 312 | I | A | 0.1389 | |
| 313 | G | A | 0.0321 | |
| 314 | S | A | -0.0850 | |
| 315 | H | A | -0.1018 | |
| 316 | A | A | -0.1358 | |
| 317 | H | A | -0.3602 | |
| 318 | C | A | -0.0677 | |
| 319 | A | A | 0.0131 | |
| 320 | F | A | 0.0711 | |
| 321 | P | A | -0.2078 | |
| 322 | S | A | -0.6032 | |
| 323 | S | A | -0.4741 | |
| 324 | Q | A | 0.0000 | |
| 325 | Q | A | -1.0062 | |
| 326 | A | A | -0.4786 | |
| 327 | D | A | 0.0000 | |
| 328 | L | A | 0.0000 | |
| 329 | T | A | -0.5880 | |
| 330 | A | A | -0.5206 | |
| 331 | F | A | 0.0000 | |
| 332 | V | A | 0.0000 | |
| 333 | N | A | -0.8311 | |
| 334 | K | A | -0.9268 | |
| 335 | F | A | 0.0000 | |
| 336 | L | A | 0.0000 | |
| 337 | L | A | -0.1710 | |
| 338 | G | A | -0.7808 | |
| 339 | Q | A | -1.3163 | |
| 340 | S | A | -0.9107 | |
| 341 | V | A | -0.7873 | |
| 342 | N | A | -1.4144 | |
| 343 | T | A | 0.0000 | |
| 344 | A | A | -0.4538 | |
| 345 | I | A | -0.0290 | |
| 346 | F | A | 0.1570 | |
| 347 | R | A | -0.6247 | |
| 348 | S | A | -0.8739 | |
| 349 | D | A | -1.6275 | |
| 350 | F | A | -0.7238 | |
| 351 | S | A | -0.9099 | |
| 352 | A | A | -0.9630 | |
| 353 | N | A | -1.4577 | |
| 354 | E | A | -1.5991 | |
| 355 | S | A | -1.4052 | |
| 356 | Q | A | -1.5521 | |
| 357 | W | A | 0.0000 | |
| 358 | I | A | 0.0000 | |
| 359 | D | A | -2.1506 | |
| 360 | W | A | 0.0000 | |
| 361 | T | A | -0.5670 | |
| 362 | T | A | -0.4526 | |
| 363 | P | A | -0.5803 | |
| 364 | T | A | -0.5972 | |
| 365 | L | A | 0.0000 | |
| 366 | S | A | -0.9203 |
ALA alanine
ARG arginine
ASN asparagine
ASP aspartic acid
CYS cysteine
GLN glutamine
GLU glutamic acid
GLY glycine
HIS histidine
ILE isoleucine
LEU leucine
LYS lysine
MET methionine
PHE phenylalanine
PRO proline
SER serine
THR threonine
TRP tryptophan
TYR tyrosine
VAL valine