| Chain sequence(s) |
A: GLPLSNPEPELLPDSEYVTPTDLLYIASTDLITEEGDPEKEIVVDGKVLKPRVSAYDFKVFKLTLPDPNKLPLPSPDAIDRETEILIWQLKAFYIGKFGPLGKGSYGHPNFNAFGDVDNPTSYQHESSDDTKNLSFYPVRKQLYIIGDEPPLGVYTAPAPPAPGLPPGAIPPTKLVTTTIQHGDKADIGFGAKDYKALEPRKNEVPDIILDTTTKVIDYEGMENEPYGDRMFDYFEKTSSYDRKNLRLSGPDPVPLPDALPPSPLYVRPPPSSPYATPPSTNLFTLPDGGEITEEDELFNKPIFFKKTKGLNNGILWHNQLYVLVLDNSRAEIEEKEVQISTPEENVYDPSNYVKSKTYKEEYQLSFILQLCRIPLTPEVLEEIKRRDPRILHDANLPFIPKVERPDPYAGLKFREIDLTNKLSSNLEKSWLGRLYLNR
input PDB |
| Selected Chain(s) | A |
| Distance of aggregation | 10 Å |
| FoldX usage | No |
| Dynamic mode | No |
| Automated mutations | No |
| Downloads | Download all the data |
| Simulation log |
[INFO] Logger: Verbosity set to: 2 - [INFO] (00:00:00)
[WARNING] runJob: Working directory already exists (possibly overwriting previous results -ow
to prevent this behavior) (00:00:00)
[INFO] runJob: Starting aggrescan3d job on: input.pdb with A chain(s) selected (00:00:00)
[INFO] runJob: Creating pdb object from: input.pdb (00:00:00)
[INFO] runJob: FoldX not utilized. Treating input pdb file as it was already optimized. (00:00:00)
[INFO] Analysis: Starting Aggrescan3D on folded.pdb (00:00:01)
[INFO] Main: Simulation completed successfully. (00:00:04)
|
The table below lists A3D score for protein residues. Residues with A3D score > 0.0000 are marked by yellow rows.
| residue index | residue name | chain | Aggrescan3D score | mutation |
|---|---|---|---|---|
| residue index | residue name | chain | Aggrescan3D score | |
| 1 | G | A | 0.4003 | |
| 2 | L | A | 1.5633 | |
| 3 | P | A | 0.8054 | |
| 4 | L | A | 0.9671 | |
| 5 | S | A | -0.1778 | |
| 6 | N | A | -1.5578 | |
| 7 | P | A | -1.8155 | |
| 8 | E | A | -2.6278 | |
| 9 | P | A | -2.0439 | |
| 10 | E | A | -2.0178 | |
| 11 | L | A | -0.4924 | |
| 12 | L | A | 0.1009 | |
| 13 | P | A | -0.2989 | |
| 14 | D | A | 0.0000 | |
| 15 | S | A | -1.1984 | |
| 16 | E | A | -1.7119 | |
| 17 | Y | A | 0.0000 | |
| 18 | V | A | 0.0000 | |
| 19 | T | A | -0.7236 | |
| 20 | P | A | -0.8067 | |
| 21 | T | A | -1.0125 | |
| 22 | D | A | -1.6461 | |
| 23 | L | A | -0.5492 | |
| 24 | L | A | -0.2144 | |
| 25 | Y | A | -0.1742 | |
| 26 | I | A | 0.0000 | |
| 27 | A | A | 0.0000 | |
| 28 | S | A | -0.5587 | |
| 29 | T | A | 0.0000 | |
| 30 | D | A | -1.2542 | |
| 31 | L | A | 0.5469 | |
| 32 | I | A | 0.0000 | |
| 33 | T | A | -0.5562 | |
| 34 | E | A | -1.3699 | |
| 35 | E | A | -2.1283 | |
| 36 | G | A | 0.0000 | |
| 37 | D | A | 0.0000 | |
| 38 | P | A | 0.0000 | |
| 39 | E | A | -1.9744 | |
| 40 | K | A | -2.7918 | |
| 41 | E | A | -1.4248 | |
| 42 | I | A | 0.7099 | |
| 43 | V | A | 1.7533 | |
| 44 | V | A | 1.2905 | |
| 45 | D | A | -1.0943 | |
| 46 | G | A | -0.6842 | |
| 47 | K | A | -0.3076 | |
| 48 | V | A | 1.6572 | |
| 49 | L | A | 2.0641 | |
| 50 | K | A | 0.3658 | |
| 51 | P | A | -0.6919 | |
| 52 | R | A | -1.8053 | |
| 53 | V | A | 0.0000 | |
| 54 | S | A | 0.0000 | |
| 55 | A | A | 0.0000 | |
| 56 | Y | A | 0.0000 | |
| 57 | D | A | 0.0000 | |
| 58 | F | A | 0.0000 | |
| 59 | K | A | 0.0000 | |
| 60 | V | A | 0.0000 | |
| 61 | F | A | 0.0000 | |
| 62 | K | A | 0.0000 | |
| 63 | L | A | 0.0000 | |
| 64 | T | A | -1.1496 | |
| 65 | L | A | 0.0000 | |
| 66 | P | A | 0.0000 | |
| 67 | D | A | -1.2141 | |
| 68 | P | A | 0.0000 | |
| 69 | N | A | -1.6695 | |
| 70 | K | A | -1.8919 | |
| 71 | L | A | -0.8935 | |
| 72 | P | A | -0.6186 | |
| 73 | L | A | -0.5727 | |
| 74 | P | A | -0.5138 | |
| 75 | S | A | -0.9319 | |
| 76 | P | A | -1.6136 | |
| 77 | D | A | -2.4869 | |
| 78 | A | A | -1.7159 | |
| 79 | I | A | 0.0000 | |
| 80 | D | A | -3.4916 | |
| 81 | R | A | -3.8605 | |
| 82 | E | A | -3.3000 | |
| 83 | T | A | -2.1389 | |
| 84 | E | A | -2.0928 | |
| 85 | I | A | 0.0000 | |
| 86 | L | A | 0.0000 | |
| 87 | I | A | 0.0000 | |
| 88 | W | A | 0.0000 | |
| 89 | Q | A | 0.0000 | |
| 90 | L | A | 0.0000 | |
| 91 | K | A | -0.5061 | |
| 92 | A | A | 0.0000 | |
| 93 | F | A | 0.0000 | |
| 94 | Y | A | -0.2472 | |
| 95 | I | A | 0.0000 | |
| 96 | G | A | 0.0000 | |
| 97 | K | A | 0.0000 | |
| 98 | F | A | 0.5255 | |
| 99 | G | A | -0.4443 | |
| 100 | P | A | -0.4048 | |
| 101 | L | A | -0.3881 | |
| 102 | G | A | -0.9773 | |
| 103 | K | A | -1.2609 | |
| 104 | G | A | 0.0000 | |
| 105 | S | A | -0.3073 | |
| 106 | Y | A | 0.0000 | |
| 107 | G | A | -0.8538 | |
| 108 | H | A | -1.7456 | |
| 109 | P | A | -1.9996 | |
| 110 | N | A | -3.0614 | |
| 111 | F | A | 0.0000 | |
| 112 | N | A | 0.0000 | |
| 113 | A | A | 0.0000 | |
| 114 | F | A | 0.0000 | |
| 115 | G | A | -1.1426 | |
| 116 | D | A | -1.7935 | |
| 117 | V | A | -1.1997 | |
| 118 | D | A | -2.4959 | |
| 119 | N | A | -2.2734 | |
| 120 | P | A | -1.4449 | |
| 121 | T | A | -0.8363 | |
| 122 | S | A | -0.5719 | |
| 123 | Y | A | -0.2513 | |
| 124 | Q | A | -1.5570 | |
| 125 | H | A | -1.8984 | |
| 126 | E | A | -2.2738 | |
| 127 | S | A | -1.8111 | |
| 128 | S | A | -1.4684 | |
| 129 | D | A | -2.6535 | |
| 130 | D | A | -2.1933 | |
| 131 | T | A | -2.3731 | |
| 132 | K | A | -3.1263 | |
| 133 | N | A | -2.6041 | |
| 134 | L | A | -1.3673 | |
| 135 | S | A | -0.6494 | |
| 136 | F | A | 0.0000 | |
| 137 | Y | A | 0.0500 | |
| 138 | P | A | 0.0000 | |
| 139 | V | A | 0.0000 | |
| 140 | R | A | 0.0000 | |
| 141 | K | A | 0.0000 | |
| 142 | Q | A | 0.0000 | |
| 143 | L | A | 0.0000 | |
| 144 | Y | A | 0.0000 | |
| 145 | I | A | 0.0000 | |
| 146 | I | A | 0.0000 | |
| 147 | G | A | 0.0000 | |
| 148 | D | A | 0.0000 | |
| 149 | E | A | -0.4073 | |
| 150 | P | A | 0.0000 | |
| 151 | P | A | 0.0000 | |
| 152 | L | A | -0.0291 | |
| 153 | G | A | 0.0000 | |
| 154 | V | A | 0.8911 | |
| 155 | Y | A | 0.5072 | |
| 156 | T | A | 0.2164 | |
| 157 | A | A | -0.3142 | |
| 158 | P | A | -0.1869 | |
| 159 | A | A | -0.4899 | |
| 160 | P | A | -0.6393 | |
| 161 | P | A | -0.2289 | |
| 162 | A | A | -0.2704 | |
| 163 | P | A | -0.4241 | |
| 164 | G | A | -0.4308 | |
| 165 | L | A | 0.2289 | |
| 166 | P | A | -0.1196 | |
| 167 | P | A | -0.2549 | |
| 168 | G | A | -0.1087 | |
| 169 | A | A | 0.6009 | |
| 170 | I | A | 1.7676 | |
| 171 | P | A | 0.6986 | |
| 172 | P | A | -0.0333 | |
| 173 | T | A | -0.2710 | |
| 174 | K | A | -0.5719 | |
| 175 | L | A | 1.1019 | |
| 176 | V | A | 0.7547 | |
| 177 | T | A | 0.5013 | |
| 178 | T | A | 0.2677 | |
| 179 | T | A | -0.1534 | |
| 180 | I | A | 0.0000 | |
| 181 | Q | A | -0.9989 | |
| 182 | H | A | -1.3090 | |
| 183 | G | A | -0.9196 | |
| 184 | D | A | -0.7318 | |
| 185 | K | A | 0.0000 | |
| 186 | A | A | 0.0000 | |
| 187 | D | A | -0.1597 | |
| 188 | I | A | 0.0000 | |
| 189 | G | A | -0.2533 | |
| 190 | F | A | -0.1225 | |
| 191 | G | A | -0.2703 | |
| 192 | A | A | 0.0594 | |
| 193 | K | A | -0.4854 | |
| 194 | D | A | -1.1190 | |
| 195 | Y | A | 0.0000 | |
| 196 | K | A | -2.8314 | |
| 197 | A | A | -1.2055 | |
| 198 | L | A | -0.8959 | |
| 199 | E | A | -2.0664 | |
| 200 | P | A | -2.4067 | |
| 201 | R | A | -3.1565 | |
| 202 | K | A | -3.6046 | |
| 203 | N | A | -2.4976 | |
| 204 | E | A | -1.5209 | |
| 205 | V | A | 0.0000 | |
| 206 | P | A | 0.0000 | |
| 207 | D | A | -1.6469 | |
| 208 | I | A | 0.0000 | |
| 209 | I | A | 0.0000 | |
| 210 | L | A | -1.6643 | |
| 211 | D | A | -2.2652 | |
| 212 | T | A | -1.1913 | |
| 213 | T | A | -0.7932 | |
| 214 | T | A | 0.0000 | |
| 215 | K | A | 0.0000 | |
| 216 | V | A | 0.6214 | |
| 217 | I | A | 0.0000 | |
| 218 | D | A | -0.7050 | |
| 219 | Y | A | -1.4319 | |
| 220 | E | A | -2.8662 | |
| 221 | G | A | -2.0668 | |
| 222 | M | A | 0.0000 | |
| 223 | E | A | -3.5800 | |
| 224 | N | A | -2.9265 | |
| 225 | E | A | -1.9768 | |
| 226 | P | A | -0.8586 | |
| 227 | Y | A | 0.0000 | |
| 228 | G | A | 0.0000 | |
| 229 | D | A | -0.6403 | |
| 230 | R | A | -0.7168 | |
| 231 | M | A | 0.0000 | |
| 232 | F | A | 0.0000 | |
| 233 | D | A | -0.4287 | |
| 234 | Y | A | 0.3648 | |
| 235 | F | A | 0.7354 | |
| 236 | E | A | -0.4837 | |
| 237 | K | A | -0.8476 | |
| 238 | T | A | -0.6194 | |
| 239 | S | A | -0.2855 | |
| 240 | S | A | -0.3892 | |
| 241 | Y | A | -0.2618 | |
| 242 | D | A | -2.1526 | |
| 243 | R | A | -2.3158 | |
| 244 | K | A | -2.6285 | |
| 245 | N | A | -1.7946 | |
| 246 | L | A | 0.0000 | |
| 247 | R | A | 0.0000 | |
| 248 | L | A | 0.0681 | |
| 249 | S | A | -0.7040 | |
| 250 | G | A | -0.7692 | |
| 251 | P | A | -0.3407 | |
| 252 | D | A | -0.0697 | |
| 253 | P | A | 0.5545 | |
| 254 | V | A | 1.4383 | |
| 255 | P | A | 0.2132 | |
| 256 | L | A | 0.3696 | |
| 257 | P | A | -0.1253 | |
| 258 | D | A | -1.4538 | |
| 259 | A | A | -0.2234 | |
| 260 | L | A | 0.5671 | |
| 261 | P | A | 0.0425 | |
| 262 | P | A | 0.1153 | |
| 263 | S | A | 0.4278 | |
| 264 | P | A | 0.9189 | |
| 265 | L | A | 1.5467 | |
| 266 | Y | A | 1.1893 | |
| 267 | V | A | 1.1559 | |
| 268 | R | A | -0.8173 | |
| 269 | P | A | -0.4736 | |
| 270 | P | A | -0.5939 | |
| 271 | P | A | -0.6604 | |
| 272 | S | A | -0.3527 | |
| 273 | S | A | -0.3010 | |
| 274 | P | A | -0.1296 | |
| 275 | Y | A | 0.2117 | |
| 276 | A | A | -0.2881 | |
| 277 | T | A | -0.3123 | |
| 278 | P | A | -0.3012 | |
| 279 | P | A | -0.5991 | |
| 280 | S | A | -0.2085 | |
| 281 | T | A | 0.3229 | |
| 282 | N | A | 0.3566 | |
| 283 | L | A | 1.4070 | |
| 284 | F | A | 0.4376 | |
| 285 | T | A | -0.7859 | |
| 286 | L | A | 0.0000 | |
| 287 | P | A | 0.0000 | |
| 288 | D | A | 0.0000 | |
| 289 | G | A | 0.0000 | |
| 290 | G | A | -1.0327 | |
| 291 | E | A | -1.8705 | |
| 292 | I | A | -1.3798 | |
| 293 | T | A | -1.8800 | |
| 294 | E | A | -2.7475 | |
| 295 | E | A | -2.8995 | |
| 296 | D | A | -2.1646 | |
| 297 | E | A | -1.7304 | |
| 298 | L | A | -1.0153 | |
| 299 | F | A | 0.0000 | |
| 300 | N | A | -1.1875 | |
| 301 | K | A | -1.7600 | |
| 302 | P | A | -0.4202 | |
| 303 | I | A | 0.0693 | |
| 304 | F | A | -0.2520 | |
| 305 | F | A | -1.0541 | |
| 306 | K | A | -2.3833 | |
| 307 | K | A | -2.9494 | |
| 308 | T | A | 0.0000 | |
| 309 | K | A | -2.4260 | |
| 310 | G | A | -1.7575 | |
| 311 | L | A | -0.3948 | |
| 312 | N | A | 0.0000 | |
| 313 | N | A | -1.2629 | |
| 314 | G | A | 0.0000 | |
| 315 | I | A | 0.0000 | |
| 316 | L | A | 0.0000 | |
| 317 | W | A | 0.0000 | |
| 318 | H | A | -0.7863 | |
| 319 | N | A | -0.6530 | |
| 320 | Q | A | -0.6144 | |
| 321 | L | A | 0.0000 | |
| 322 | Y | A | 0.0000 | |
| 323 | V | A | 0.0000 | |
| 324 | L | A | 0.0000 | |
| 325 | V | A | 0.0000 | |
| 326 | L | A | 0.0000 | |
| 327 | D | A | 0.0000 | |
| 328 | N | A | 0.0000 | |
| 329 | S | A | 0.0000 | |
| 330 | R | A | 0.0000 | |
| 331 | A | A | 0.0000 | |
| 332 | E | A | -2.4115 | |
| 333 | I | A | -2.3892 | |
| 334 | E | A | -3.7853 | |
| 335 | E | A | -4.4558 | |
| 336 | K | A | -4.0016 | |
| 337 | E | A | -2.5245 | |
| 338 | V | A | 0.4370 | |
| 339 | Q | A | 0.5538 | |
| 340 | I | A | 2.0846 | |
| 341 | S | A | 0.6383 | |
| 342 | T | A | -0.6372 | |
| 343 | P | A | -1.2421 | |
| 344 | E | A | -2.5537 | |
| 345 | E | A | -2.7327 | |
| 346 | N | A | -1.7274 | |
| 347 | V | A | -0.0273 | |
| 348 | Y | A | 0.5807 | |
| 349 | D | A | -0.3549 | |
| 350 | P | A | -0.2312 | |
| 351 | S | A | 0.0890 | |
| 352 | N | A | 0.3006 | |
| 353 | Y | A | 0.6400 | |
| 354 | V | A | 0.3696 | |
| 355 | K | A | -2.7847 | |
| 356 | S | A | -2.5388 | |
| 357 | K | A | -3.2032 | |
| 358 | T | A | 0.0000 | |
| 359 | Y | A | 0.0000 | |
| 360 | K | A | -2.0912 | |
| 361 | E | A | 0.0000 | |
| 362 | E | A | -0.2701 | |
| 363 | Y | A | 0.0000 | |
| 364 | Q | A | -0.3326 | |
| 365 | L | A | 0.0000 | |
| 366 | S | A | 0.0000 | |
| 367 | F | A | 0.0000 | |
| 368 | I | A | 0.0000 | |
| 369 | L | A | 0.0000 | |
| 370 | Q | A | -0.4239 | |
| 371 | L | A | 0.0000 | |
| 372 | C | A | 0.0000 | |
| 373 | R | A | -1.0888 | |
| 374 | I | A | 0.0000 | |
| 375 | P | A | -1.0336 | |
| 376 | L | A | -0.9778 | |
| 377 | T | A | -0.8711 | |
| 378 | P | A | -1.4791 | |
| 379 | E | A | -2.5647 | |
| 380 | V | A | -1.7210 | |
| 381 | L | A | -1.8484 | |
| 382 | E | A | -3.2337 | |
| 383 | E | A | 0.0000 | |
| 384 | I | A | 0.0000 | |
| 385 | K | A | -3.1197 | |
| 386 | R | A | -2.3359 | |
| 387 | R | A | -1.4394 | |
| 388 | D | A | 0.0000 | |
| 389 | P | A | -1.7059 | |
| 390 | R | A | -1.5843 | |
| 391 | I | A | 0.0000 | |
| 392 | L | A | 0.0000 | |
| 393 | H | A | -1.9809 | |
| 394 | D | A | -2.4709 | |
| 395 | A | A | -1.5237 | |
| 396 | N | A | -1.9207 | |
| 397 | L | A | 0.0000 | |
| 398 | P | A | -0.0274 | |
| 399 | F | A | 1.4733 | |
| 400 | I | A | 0.3673 | |
| 401 | P | A | -0.4494 | |
| 402 | K | A | -1.8074 | |
| 403 | V | A | -0.6379 | |
| 404 | E | A | -2.5717 | |
| 405 | R | A | -2.7918 | |
| 406 | P | A | -1.7898 | |
| 407 | D | A | -1.7671 | |
| 408 | P | A | -0.9200 | |
| 409 | Y | A | -0.5576 | |
| 410 | A | A | -0.6581 | |
| 411 | G | A | -0.7165 | |
| 412 | L | A | -0.6532 | |
| 413 | K | A | -2.0940 | |
| 414 | F | A | -1.6908 | |
| 415 | R | A | -2.3275 | |
| 416 | E | A | -2.7933 | |
| 417 | I | A | -1.9908 | |
| 418 | D | A | -2.6242 | |
| 419 | L | A | 0.0000 | |
| 420 | T | A | -1.4607 | |
| 421 | N | A | -2.0112 | |
| 422 | K | A | -1.9873 | |
| 423 | L | A | -0.6972 | |
| 424 | S | A | -1.0052 | |
| 425 | S | A | -0.7592 | |
| 426 | N | A | -1.8328 | |
| 427 | L | A | 0.0000 | |
| 428 | E | A | -2.8463 | |
| 429 | K | A | -2.8679 | |
| 430 | S | A | -1.4135 | |
| 431 | W | A | -0.1657 | |
| 432 | L | A | 0.0000 | |
| 433 | G | A | 0.0000 | |
| 434 | R | A | -1.7831 | |
| 435 | L | A | -0.4809 | |
| 436 | Y | A | -0.3120 | |
| 437 | L | A | -0.4051 | |
| 438 | N | A | -1.6397 | |
| 439 | R | A | -1.9938 |
ALA alanine
ARG arginine
ASN asparagine
ASP aspartic acid
CYS cysteine
GLN glutamine
GLU glutamic acid
GLY glycine
HIS histidine
ILE isoleucine
LEU leucine
LYS lysine
MET methionine
PHE phenylalanine
PRO proline
SER serine
THR threonine
TRP tryptophan
TYR tyrosine
VAL valine