Project name: f5d1b522a6d0a4a

Chain sequence(s)	A: EVKLEESGGGLVQQPGGSMKLSCVASGFIFSNHWMNWVRQSPEKGLEWVAEIRSKSINSATHYAESVKGRFTISRDDSKSAVYLQMTDLRTEDTGVYYCSRNYYGSTYDYWGQGTTLTVSSASTKGPSVFPLAPSSKSTSGGTAALGCLVKDYFPEPVTVSWNSGALTSGVHTFPAVLQSSGLYSLSSVVTVPSSSLGTQTYICNVNHKPSNTKVDKKVEPK
Selected Chain(s)	A
Distance of aggregation	5 Å
FoldX usage	Yes
Dynamic mode	No
Automated mutations	No

Simulation log

[INFO]       Logger:   Verbosity set to: 2 - [INFO]                                                (00:00:00)
[WARNING]    runJob:   Working directory already exists (possibly overwriting previous results -ow 
                       to prevent this behavior)                                                   (00:00:00)
[INFO]       runJob:   Starting aggrescan3d job on: input.pdb with A chain(s) selected             (00:00:00)
[INFO]       runJob:   Creating pdb object from: input.pdb                                         (00:00:00)
[INFO]       FoldX:    Starting FoldX energy minimalization                                        (00:00:00)
[INFO]       Analysis: Starting Aggrescan3D on folded.pdb                                          (00:01:36)
[INFO]       Main:     Simulation completed successfully.                                          (00:01:37)

• Minimal score value: -2.1788
• Maximal score value: 2.0675
• Average score: -0.2358
• Total score value: -52.1172

The table below lists A3D score for protein residues. Residues with A3D score > 0.0000 are marked by yellow rows.

residue index	residue name	chain	Aggrescan3D score	mutation
1	E	A	-1.7479
2	V	A	-0.3238
3	K	A	-1.6282
4	L	A	0.0000
5	E	A	-1.8541
6	E	A	-0.5600
7	S	A	-0.2827
8	G	A	-0.2316
9	G	A	0.0000
10	G	A	0.0030
11	L	A	0.2565
12	V	A	0.0000
13	Q	A	-1.2274
14	P	A	-0.4642
15	G	A	-0.7796
16	G	A	-0.1598
17	S	A	-0.1431
18	M	A	-0.1796
19	K	A	-1.5518
20	L	A	0.0000
21	S	A	-0.0184
22	C	A	0.0000
23	V	A	0.8460
24	A	A	0.0000
25	S	A	-0.2809
26	G	A	-0.3906
27	F	A	0.5832
28	I	A	2.0675
29	F	A	0.0000
30	S	A	-0.3508
31	N	A	-1.3133
32	H	A	-0.3096
33	W	A	0.0505
34	M	A	0.0000
35	N	A	0.0000
36	W	A	0.0000
37	V	A	0.0000
38	R	A	0.0000
39	Q	A	-0.4492
40	S	A	-0.1878
41	P	A	-0.5921
42	E	A	-2.1788
43	K	A	-2.0686
44	G	A	-0.2140
45	L	A	1.3843
46	E	A	0.0990
47	W	A	0.3182
48	V	A	0.0000
49	A	A	0.0000
50	E	A	0.0000
51	I	A	0.0000
52	R	A	-0.4317
53	S	A	0.0000
54	K	A	-1.8778
55	S	A	-0.2520
56	I	A	1.2252
57	N	A	-1.1861
58	S	A	-0.5696
59	A	A	-0.0004
60	T	A	-0.1024
61	H	A	-0.3769
62	Y	A	0.1237
63	A	A	0.0000
64	E	A	-1.8363
65	S	A	-0.4246
66	V	A	0.0000
67	K	A	-1.7863
68	G	A	-0.7810
69	R	A	0.0000
70	F	A	0.0000
71	T	A	-0.0626
72	I	A	0.0000
73	S	A	-0.1570
74	R	A	-0.3324
75	D	A	-0.6716
76	D	A	-0.4420
77	S	A	-0.5768
78	K	A	-1.7481
79	S	A	-0.3901
80	A	A	0.0000
81	V	A	0.0000
82	Y	A	0.3337
83	L	A	0.0000
84	Q	A	-0.5768
85	M	A	0.0000
86	T	A	-0.3791
87	D	A	-1.8665
88	L	A	0.0000
89	R	A	-1.0914
90	T	A	-0.6043
91	E	A	-1.8329
92	D	A	0.0000
93	T	A	-0.0282
94	G	A	0.0000
95	V	A	0.4775
96	Y	A	0.0000
97	Y	A	0.1948
98	C	A	0.0000
99	S	A	0.0000
100	R	A	0.0000
101	N	A	0.0000
102	Y	A	1.0910
103	Y	A	0.7421
104	G	A	-0.3856
105	S	A	-0.3097
106	T	A	-0.0218
107	Y	A	0.2560
108	D	A	-0.4769
109	Y	A	0.5560
110	W	A	0.6043
111	G	A	-0.1846
112	Q	A	-1.2288
113	G	A	-0.2997
114	T	A	-0.0301
115	T	A	0.0511
116	L	A	0.0000
117	T	A	0.0185
118	V	A	0.0000
119	S	A	-0.0781
120	S	A	-0.2123
121	A	A	-0.0359
122	S	A	-0.2133
123	T	A	-0.2489
124	K	A	-0.9193
125	G	A	-0.2741
126	P	A	0.0000
127	S	A	-0.1021
128	V	A	0.0000
129	F	A	1.2326
130	P	A	0.1612
131	L	A	0.5829
132	A	A	0.1305
133	P	A	0.0000
134	S	A	-0.0660
135	S	A	-0.5326
136	K	A	-1.7522
137	S	A	-0.3851
138	T	A	-0.0987
139	S	A	-0.3033
140	G	A	-0.5930
141	G	A	-0.5606
142	T	A	-0.1491
143	A	A	0.0000
144	A	A	0.0106
145	L	A	0.0000
146	G	A	0.0000
147	C	A	0.0000
148	L	A	0.4882
149	V	A	0.0000
150	K	A	-0.6183
151	D	A	-0.4396
152	Y	A	0.0000
153	F	A	0.0000
154	P	A	0.0000
155	E	A	-0.5423
156	P	A	-0.2737
157	V	A	0.1398
158	T	A	0.0030
159	V	A	0.1877
160	S	A	-0.0305
161	W	A	0.0000
162	N	A	-0.2935
163	S	A	-0.3460
164	G	A	-0.4950
165	A	A	0.0236
166	L	A	0.2808
167	T	A	-0.0580
168	S	A	-0.2897
169	G	A	-0.2909
170	V	A	0.2972
171	H	A	-0.7123
172	T	A	0.0015
173	F	A	0.9278
174	P	A	-0.0722
175	A	A	0.2925
176	V	A	2.0593
177	L	A	1.8535
178	Q	A	-0.0126
179	S	A	-0.2992
180	S	A	-0.3012
181	G	A	-0.2616
182	L	A	0.1966
183	Y	A	0.4540
184	S	A	0.0000
185	L	A	0.0000
186	S	A	0.0007
187	S	A	0.0000
188	V	A	0.3812
189	V	A	0.0000
190	T	A	-0.0439
191	V	A	0.0000
192	P	A	-0.2698
193	S	A	-0.1454
194	S	A	-0.2281
195	S	A	-0.0160
196	L	A	0.1709
197	G	A	-0.4308
198	T	A	-0.3235
199	Q	A	-0.9432
200	T	A	-0.2078
201	Y	A	0.0000
202	I	A	0.2769
203	C	A	0.0000
204	N	A	-0.3684
205	V	A	0.0000
206	N	A	-0.6262
207	H	A	0.0000
208	K	A	-1.7997
209	P	A	-0.3515
210	S	A	-0.3036
211	N	A	-1.4833
212	T	A	-0.5592
213	K	A	-1.6838
214	V	A	-0.2536
215	D	A	-1.8392
216	K	A	-1.1744
217	K	A	-1.5651
218	V	A	0.0000
219	E	A	-1.8331
220	P	A	-0.7182
221	K	A	-1.7133