| Chain sequence(s) |
A: GLPAFNPEPKLKSTDEYVTPTDLLYYAETDLITFEGHPEKDIVENGKVVVPKVSAYDFLVFKLTLPDPNKLPLPSEDFIDPSTEILIWQLKAYKIEVYGPLGKGEYGHPNFNRLGNVDNPTSYVHEGADNTVSYSFYPKRKQFYIIGDEPPIGVYTAKAEPAPGLPPGAEPPTTEVRDIIEDGDVADIGFGAKDYKALEPSKNDVPDIIMDTKTKVFDYEGMKAEPYGRRMFDYDEYESKKDIETLRRCGPVLNPLPDENPPSPLYIPPPPWSPYWELPSYDYFTIPDEGEITESDLLFNKPIFLEKTEGLNNGILWHNKLYITVLDNTRSEIEEIREQKSVPEEDVYNEEDYETSKRYTREYKLSLILQLCKIPLTPETLEEIRRIDPRILVDANLPDIPPVEREDPYKGKKFIEIDLTNKLSTDLSKSDLGQEYLNR
input PDB |
| Selected Chain(s) | A |
| Distance of aggregation | 10 Å |
| FoldX usage | No |
| Dynamic mode | No |
| Automated mutations | No |
| Downloads | Download all the data |
| Simulation log |
[INFO] Logger: Verbosity set to: 2 - [INFO] (00:00:00)
[WARNING] runJob: Working directory already exists (possibly overwriting previous results -ow
to prevent this behavior) (00:00:00)
[INFO] runJob: Starting aggrescan3d job on: input.pdb with A chain(s) selected (00:00:00)
[INFO] runJob: Creating pdb object from: input.pdb (00:00:00)
[INFO] runJob: FoldX not utilized. Treating input pdb file as it was already optimized. (00:00:00)
[INFO] Analysis: Starting Aggrescan3D on folded.pdb (00:00:01)
[INFO] Main: Simulation completed successfully. (00:00:04)
|
The table below lists A3D score for protein residues. Residues with A3D score > 0.0000 are marked by yellow rows.
| residue index | residue name | chain | Aggrescan3D score | mutation |
|---|---|---|---|---|
| residue index | residue name | chain | Aggrescan3D score | |
| 1 | G | A | 0.2091 | |
| 2 | L | A | 1.5016 | |
| 3 | P | A | 0.7521 | |
| 4 | A | A | 0.7865 | |
| 5 | F | A | 1.1653 | |
| 6 | N | A | -0.9838 | |
| 7 | P | A | -1.5006 | |
| 8 | E | A | -2.5070 | |
| 9 | P | A | -2.1725 | |
| 10 | K | A | -2.3000 | |
| 11 | L | A | -1.1311 | |
| 12 | K | A | -1.7513 | |
| 13 | S | A | -1.6140 | |
| 14 | T | A | 0.0000 | |
| 15 | D | A | -3.0317 | |
| 16 | E | A | -2.8786 | |
| 17 | Y | A | 0.0000 | |
| 18 | V | A | 0.0000 | |
| 19 | T | A | -0.9720 | |
| 20 | P | A | -0.9645 | |
| 21 | T | A | -0.9408 | |
| 22 | D | A | -1.6783 | |
| 23 | L | A | -0.5497 | |
| 24 | L | A | -0.2413 | |
| 25 | Y | A | 0.0000 | |
| 26 | Y | A | -0.3496 | |
| 27 | A | A | 0.0000 | |
| 28 | E | A | -0.8408 | |
| 29 | T | A | 0.0000 | |
| 30 | D | A | -1.2091 | |
| 31 | L | A | 0.5453 | |
| 32 | I | A | 0.4273 | |
| 33 | T | A | -0.0901 | |
| 34 | F | A | -0.5262 | |
| 35 | E | A | -1.6387 | |
| 36 | G | A | 0.0000 | |
| 37 | H | A | -1.9437 | |
| 38 | P | A | 0.0000 | |
| 39 | E | A | -1.7815 | |
| 40 | K | A | -2.0961 | |
| 41 | D | A | -1.1221 | |
| 42 | I | A | 0.5673 | |
| 43 | V | A | 0.7031 | |
| 44 | E | A | -1.4752 | |
| 45 | N | A | -2.0927 | |
| 46 | G | A | -1.4066 | |
| 47 | K | A | -1.1838 | |
| 48 | V | A | 1.1047 | |
| 49 | V | A | 1.5278 | |
| 50 | V | A | 0.7247 | |
| 51 | P | A | -0.1948 | |
| 52 | K | A | -1.4637 | |
| 53 | V | A | 0.0000 | |
| 54 | S | A | 0.0000 | |
| 55 | A | A | 0.0000 | |
| 56 | Y | A | 0.0000 | |
| 57 | D | A | 0.0000 | |
| 58 | F | A | 0.0000 | |
| 59 | L | A | 0.0000 | |
| 60 | V | A | 0.0000 | |
| 61 | F | A | 0.0000 | |
| 62 | K | A | -1.2465 | |
| 63 | L | A | 0.0000 | |
| 64 | T | A | -1.2756 | |
| 65 | L | A | 0.0000 | |
| 66 | P | A | -1.2700 | |
| 67 | D | A | -1.3689 | |
| 68 | P | A | 0.0000 | |
| 69 | N | A | -1.8543 | |
| 70 | K | A | -2.0993 | |
| 71 | L | A | -0.9558 | |
| 72 | P | A | -0.7133 | |
| 73 | L | A | -0.6217 | |
| 74 | P | A | -0.6738 | |
| 75 | S | A | -1.5085 | |
| 76 | E | A | -2.7958 | |
| 77 | D | A | -2.8057 | |
| 78 | F | A | -1.4153 | |
| 79 | I | A | -1.5638 | |
| 80 | D | A | -2.1710 | |
| 81 | P | A | -1.3158 | |
| 82 | S | A | -0.8591 | |
| 83 | T | A | -0.8073 | |
| 84 | E | A | -1.0710 | |
| 85 | I | A | 0.0000 | |
| 86 | L | A | 0.0000 | |
| 87 | I | A | 0.0000 | |
| 88 | W | A | 0.0000 | |
| 89 | Q | A | 0.0000 | |
| 90 | L | A | 0.0000 | |
| 91 | K | A | -0.6457 | |
| 92 | A | A | 0.0000 | |
| 93 | Y | A | 0.0000 | |
| 94 | K | A | -0.9444 | |
| 95 | I | A | 0.0000 | |
| 96 | E | A | -0.6700 | |
| 97 | V | A | 0.0000 | |
| 98 | Y | A | 0.2456 | |
| 99 | G | A | -0.4412 | |
| 100 | P | A | -0.4023 | |
| 101 | L | A | -0.1976 | |
| 102 | G | A | -0.9763 | |
| 103 | K | A | -1.5982 | |
| 104 | G | A | 0.0000 | |
| 105 | E | A | -1.5907 | |
| 106 | Y | A | 0.0000 | |
| 107 | G | A | -0.8401 | |
| 108 | H | A | -1.1060 | |
| 109 | P | A | -0.9841 | |
| 110 | N | A | -1.9636 | |
| 111 | F | A | 0.0000 | |
| 112 | N | A | -1.2856 | |
| 113 | R | A | -0.7181 | |
| 114 | L | A | -0.7001 | |
| 115 | G | A | -0.7034 | |
| 116 | N | A | -1.1718 | |
| 117 | V | A | -0.9642 | |
| 118 | D | A | -2.4148 | |
| 119 | N | A | -2.3536 | |
| 120 | P | A | -1.3227 | |
| 121 | T | A | -0.7473 | |
| 122 | S | A | -0.4123 | |
| 123 | Y | A | 0.1678 | |
| 124 | V | A | -0.3928 | |
| 125 | H | A | -1.4915 | |
| 126 | E | A | -2.1627 | |
| 127 | G | A | -1.7650 | |
| 128 | A | A | -1.3081 | |
| 129 | D | A | -2.3399 | |
| 130 | N | A | -1.7404 | |
| 131 | T | A | -1.1589 | |
| 132 | V | A | -0.4033 | |
| 133 | S | A | -0.5085 | |
| 134 | Y | A | -0.2935 | |
| 135 | S | A | -0.4863 | |
| 136 | F | A | 0.0000 | |
| 137 | Y | A | -0.5353 | |
| 138 | P | A | 0.0000 | |
| 139 | K | A | 0.0000 | |
| 140 | R | A | 0.0000 | |
| 141 | K | A | 0.0000 | |
| 142 | Q | A | 0.0000 | |
| 143 | F | A | 0.0000 | |
| 144 | Y | A | 0.0000 | |
| 145 | I | A | 0.0000 | |
| 146 | I | A | 0.0000 | |
| 147 | G | A | 0.0000 | |
| 148 | D | A | 0.0000 | |
| 149 | E | A | -0.2975 | |
| 150 | P | A | 0.0000 | |
| 151 | P | A | 0.0000 | |
| 152 | I | A | -0.1972 | |
| 153 | G | A | 0.0000 | |
| 154 | V | A | -0.8502 | |
| 155 | Y | A | 0.0000 | |
| 156 | T | A | -1.5364 | |
| 157 | A | A | -1.8867 | |
| 158 | K | A | -2.6046 | |
| 159 | A | A | -2.0258 | |
| 160 | E | A | -2.3571 | |
| 161 | P | A | -1.5109 | |
| 162 | A | A | -0.5348 | |
| 163 | P | A | -0.5260 | |
| 164 | G | A | -0.2832 | |
| 165 | L | A | 0.0082 | |
| 166 | P | A | -0.4746 | |
| 167 | P | A | -0.7098 | |
| 168 | G | A | -0.7320 | |
| 169 | A | A | -0.9755 | |
| 170 | E | A | -1.8436 | |
| 171 | P | A | -1.7100 | |
| 172 | P | A | -1.4275 | |
| 173 | T | A | -1.7098 | |
| 174 | T | A | -1.7604 | |
| 175 | E | A | -2.3523 | |
| 176 | V | A | -1.6969 | |
| 177 | R | A | -2.1036 | |
| 178 | D | A | -1.3575 | |
| 179 | I | A | -0.7250 | |
| 180 | I | A | 0.0000 | |
| 181 | E | A | -1.2854 | |
| 182 | D | A | -1.3325 | |
| 183 | G | A | -1.0617 | |
| 184 | D | A | -1.0789 | |
| 185 | V | A | 0.0000 | |
| 186 | A | A | 0.0000 | |
| 187 | D | A | 0.0000 | |
| 188 | I | A | 0.0000 | |
| 189 | G | A | -0.6107 | |
| 190 | F | A | 0.0891 | |
| 191 | G | A | -0.1603 | |
| 192 | A | A | -0.4988 | |
| 193 | K | A | -1.3287 | |
| 194 | D | A | -1.9133 | |
| 195 | Y | A | 0.0000 | |
| 196 | K | A | -3.2805 | |
| 197 | A | A | -1.8130 | |
| 198 | L | A | -1.4783 | |
| 199 | E | A | -1.6397 | |
| 200 | P | A | -1.7170 | |
| 201 | S | A | -1.5445 | |
| 202 | K | A | -2.9903 | |
| 203 | N | A | -1.8835 | |
| 204 | D | A | -1.3169 | |
| 205 | V | A | 0.0000 | |
| 206 | P | A | 0.0000 | |
| 207 | D | A | -1.8233 | |
| 208 | I | A | 0.0000 | |
| 209 | I | A | 0.0000 | |
| 210 | M | A | -2.2744 | |
| 211 | D | A | -3.1457 | |
| 212 | T | A | -2.0809 | |
| 213 | K | A | -1.9772 | |
| 214 | T | A | 0.0000 | |
| 215 | K | A | 0.0000 | |
| 216 | V | A | 0.3970 | |
| 217 | F | A | 0.0000 | |
| 218 | D | A | 0.0000 | |
| 219 | Y | A | -1.0385 | |
| 220 | E | A | -2.3776 | |
| 221 | G | A | -1.7194 | |
| 222 | M | A | 0.0000 | |
| 223 | K | A | -2.7306 | |
| 224 | A | A | -1.5184 | |
| 225 | E | A | -1.2650 | |
| 226 | P | A | -0.7939 | |
| 227 | Y | A | 0.0000 | |
| 228 | G | A | 0.0000 | |
| 229 | R | A | 0.0000 | |
| 230 | R | A | -0.5568 | |
| 231 | M | A | 0.0000 | |
| 232 | F | A | 0.0000 | |
| 233 | D | A | -0.8379 | |
| 234 | Y | A | -0.3548 | |
| 235 | D | A | -0.9750 | |
| 236 | E | A | -1.1531 | |
| 237 | Y | A | -0.9328 | |
| 238 | E | A | -1.7817 | |
| 239 | S | A | -1.8651 | |
| 240 | K | A | -2.6051 | |
| 241 | K | A | -3.0806 | |
| 242 | D | A | -2.4223 | |
| 243 | I | A | -0.7742 | |
| 244 | E | A | -1.2240 | |
| 245 | T | A | -0.6885 | |
| 246 | L | A | 0.0000 | |
| 247 | R | A | -0.1591 | |
| 248 | R | A | 0.0000 | |
| 249 | C | A | -0.8494 | |
| 250 | G | A | -0.5155 | |
| 251 | P | A | -0.0696 | |
| 252 | V | A | 0.5974 | |
| 253 | L | A | 0.6575 | |
| 254 | N | A | -0.6407 | |
| 255 | P | A | -0.3517 | |
| 256 | L | A | -0.1201 | |
| 257 | P | A | -1.5810 | |
| 258 | D | A | -2.8454 | |
| 259 | E | A | -3.4196 | |
| 260 | N | A | -2.5493 | |
| 261 | P | A | -1.1272 | |
| 262 | P | A | -0.6249 | |
| 263 | S | A | -0.3198 | |
| 264 | P | A | 0.6140 | |
| 265 | L | A | 1.7573 | |
| 266 | Y | A | 1.6813 | |
| 267 | I | A | 2.0855 | |
| 268 | P | A | 0.5508 | |
| 269 | P | A | 0.9141 | |
| 270 | P | A | 0.7043 | |
| 271 | P | A | 0.4093 | |
| 272 | W | A | 1.3281 | |
| 273 | S | A | 0.7846 | |
| 274 | P | A | 0.5287 | |
| 275 | Y | A | 1.2140 | |
| 276 | W | A | 0.8513 | |
| 277 | E | A | -0.9230 | |
| 278 | L | A | 0.2143 | |
| 279 | P | A | -0.2899 | |
| 280 | S | A | 0.0000 | |
| 281 | Y | A | 0.3450 | |
| 282 | D | A | -0.3202 | |
| 283 | Y | A | 0.8430 | |
| 284 | F | A | 0.2839 | |
| 285 | T | A | -0.2407 | |
| 286 | I | A | 0.0000 | |
| 287 | P | A | 0.0000 | |
| 288 | D | A | -1.6756 | |
| 289 | E | A | 0.0000 | |
| 290 | G | A | -1.7652 | |
| 291 | E | A | -2.0435 | |
| 292 | I | A | -1.0989 | |
| 293 | T | A | -1.2885 | |
| 294 | E | A | -1.8129 | |
| 295 | S | A | -1.1465 | |
| 296 | D | A | -1.1370 | |
| 297 | L | A | -0.7508 | |
| 298 | L | A | -0.6911 | |
| 299 | F | A | 0.0000 | |
| 300 | N | A | -1.3616 | |
| 301 | K | A | -1.7716 | |
| 302 | P | A | -1.0071 | |
| 303 | I | A | -0.0801 | |
| 304 | F | A | -0.5545 | |
| 305 | L | A | 0.0000 | |
| 306 | E | A | -2.5623 | |
| 307 | K | A | -3.2407 | |
| 308 | T | A | 0.0000 | |
| 309 | E | A | -2.5606 | |
| 310 | G | A | -1.5848 | |
| 311 | L | A | -1.0131 | |
| 312 | N | A | 0.0000 | |
| 313 | N | A | -1.6300 | |
| 314 | G | A | 0.0000 | |
| 315 | I | A | 0.0000 | |
| 316 | L | A | 0.0000 | |
| 317 | W | A | 0.0000 | |
| 318 | H | A | -0.7480 | |
| 319 | N | A | -0.6920 | |
| 320 | K | A | -0.8138 | |
| 321 | L | A | 0.0000 | |
| 322 | Y | A | 0.0000 | |
| 323 | I | A | 0.0000 | |
| 324 | T | A | 0.0000 | |
| 325 | V | A | 0.0000 | |
| 326 | L | A | 0.0000 | |
| 327 | D | A | 0.0000 | |
| 328 | N | A | 0.0000 | |
| 329 | T | A | 0.0000 | |
| 330 | R | A | -0.6301 | |
| 331 | S | A | 0.0000 | |
| 332 | E | A | -2.9149 | |
| 333 | I | A | -2.7339 | |
| 334 | E | A | -3.6812 | |
| 335 | E | A | -3.7568 | |
| 336 | I | A | -2.7537 | |
| 337 | R | A | -4.0823 | |
| 338 | E | A | -4.1690 | |
| 339 | Q | A | -3.5182 | |
| 340 | K | A | -3.2005 | |
| 341 | S | A | -1.1449 | |
| 342 | V | A | 0.1745 | |
| 343 | P | A | -1.2302 | |
| 344 | E | A | -2.4617 | |
| 345 | E | A | -2.6676 | |
| 346 | D | A | -1.8457 | |
| 347 | V | A | 0.4343 | |
| 348 | Y | A | 0.3556 | |
| 349 | N | A | -1.8200 | |
| 350 | E | A | -3.1839 | |
| 351 | E | A | -3.5815 | |
| 352 | D | A | -3.1273 | |
| 353 | Y | A | -3.6861 | |
| 354 | E | A | -4.0559 | |
| 355 | T | A | -2.6502 | |
| 356 | S | A | -2.5446 | |
| 357 | K | A | -2.6351 | |
| 358 | R | A | -2.9647 | |
| 359 | Y | A | 0.0000 | |
| 360 | T | A | -1.3831 | |
| 361 | R | A | 0.0000 | |
| 362 | E | A | -0.1590 | |
| 363 | Y | A | 0.0000 | |
| 364 | K | A | -0.4679 | |
| 365 | L | A | 0.0000 | |
| 366 | S | A | 0.0000 | |
| 367 | L | A | 0.0000 | |
| 368 | I | A | 0.0000 | |
| 369 | L | A | 0.0000 | |
| 370 | Q | A | -0.4026 | |
| 371 | L | A | 0.0000 | |
| 372 | C | A | 0.0000 | |
| 373 | K | A | -0.5554 | |
| 374 | I | A | 0.0000 | |
| 375 | P | A | -0.6560 | |
| 376 | L | A | -0.4647 | |
| 377 | T | A | -0.8329 | |
| 378 | P | A | -1.3271 | |
| 379 | E | A | -2.3586 | |
| 380 | T | A | 0.0000 | |
| 381 | L | A | -1.4393 | |
| 382 | E | A | -2.4109 | |
| 383 | E | A | 0.0000 | |
| 384 | I | A | 0.0000 | |
| 385 | R | A | -2.5688 | |
| 386 | R | A | -1.8886 | |
| 387 | I | A | -1.0412 | |
| 388 | D | A | 0.0000 | |
| 389 | P | A | -1.5325 | |
| 390 | R | A | -1.4990 | |
| 391 | I | A | 0.0000 | |
| 392 | L | A | 0.0000 | |
| 393 | V | A | -1.1840 | |
| 394 | D | A | -1.1363 | |
| 395 | A | A | -1.0085 | |
| 396 | N | A | -1.6935 | |
| 397 | L | A | -1.1487 | |
| 398 | P | A | -1.3246 | |
| 399 | D | A | -1.9457 | |
| 400 | I | A | -0.7300 | |
| 401 | P | A | -0.5262 | |
| 402 | P | A | -0.5960 | |
| 403 | V | A | -0.0609 | |
| 404 | E | A | -2.4807 | |
| 405 | R | A | -3.6520 | |
| 406 | E | A | -3.9196 | |
| 407 | D | A | -3.4651 | |
| 408 | P | A | -2.0911 | |
| 409 | Y | A | -1.9609 | |
| 410 | K | A | -3.0623 | |
| 411 | G | A | -2.0798 | |
| 412 | K | A | -2.2854 | |
| 413 | K | A | -2.7107 | |
| 414 | F | A | -1.4902 | |
| 415 | I | A | -1.2568 | |
| 416 | E | A | -2.2517 | |
| 417 | I | A | -1.7210 | |
| 418 | D | A | -2.4971 | |
| 419 | L | A | 0.0000 | |
| 420 | T | A | -1.3808 | |
| 421 | N | A | -1.8333 | |
| 422 | K | A | -1.6797 | |
| 423 | L | A | -0.5395 | |
| 424 | S | A | -0.7097 | |
| 425 | T | A | -0.4680 | |
| 426 | D | A | -1.3212 | |
| 427 | L | A | 0.0000 | |
| 428 | S | A | -1.6726 | |
| 429 | K | A | -2.5498 | |
| 430 | S | A | 0.0000 | |
| 431 | D | A | -2.6598 | |
| 432 | L | A | 0.0000 | |
| 433 | G | A | 0.0000 | |
| 434 | Q | A | -2.2663 | |
| 435 | E | A | -1.9907 | |
| 436 | Y | A | -0.8213 | |
| 437 | L | A | -0.1189 | |
| 438 | N | A | -1.8208 | |
| 439 | R | A | -2.1256 |
ALA alanine
ARG arginine
ASN asparagine
ASP aspartic acid
CYS cysteine
GLN glutamine
GLU glutamic acid
GLY glycine
HIS histidine
ILE isoleucine
LEU leucine
LYS lysine
MET methionine
PHE phenylalanine
PRO proline
SER serine
THR threonine
TRP tryptophan
TYR tyrosine
VAL valine