Project name: f8721c0abca68f8

Chain sequence(s)	H: EVQLVESGGGLVQPGGSLRLSCAASGFTFDDAWMSWVRQAPGKGLEWVAEISTKANNHATYYAESVKGRFTISRDDSKSSVYLQMNSLRAEDTAVYYCTRLATWDWYFDVWGQGTTVTVSS; L: DIVLTQSPSSLSASVGDRVTITCRASQSVDYDGDSYMNWYQQKPGKPPKLLIYAASELESGIPARFSGSGSGTDFTLTISSLQPEDFATYYCQQSNEDPFTFGSGTKLEIK
Selected Chain(s)	H,L
Distance of aggregation	10 Å
FoldX usage	Yes
Dynamic mode	No
Automated mutations	No

Simulation log

[INFO]       Logger:   Verbosity set to: 2 - [INFO]                                                (00:00:00)
[WARNING]    runJob:   Working directory already exists (possibly overwriting previous results -ow 
                       to prevent this behavior)                                                   (00:00:00)
[INFO]       runJob:   Starting aggrescan3d job on: input.pdb with all chain(s) selected           (00:00:00)
[INFO]       runJob:   Creating pdb object from: input.pdb                                         (00:00:00)
[INFO]       FoldX:    Starting FoldX energy minimalization                                        (00:00:00)
[INFO]       Analysis: Starting Aggrescan3D on folded.pdb                                          (00:01:17)
[INFO]       Main:     Simulation completed successfully.                                          (00:01:18)

• Minimal score value: -3.0127
• Maximal score value: 1.2623
• Average score: -0.6135
• Total score value: -142.3433

The table below lists A3D score for protein residues. Residues with A3D score > 0.0000 are marked by yellow rows.

residue index	residue name	chain	Aggrescan3D score	mutation
1	E	H	-1.7259
2	V	H	-0.4798
3	Q	H	-0.9813
4	L	H	0.0000
5	V	H	0.3760
6	E	H	0.0000
7	S	H	-0.5031
8	G	H	-0.7847
9	G	H	-0.2847
11	G	H	0.4289
12	L	H	1.1828
13	V	H	0.0298
14	Q	H	-1.2772
15	P	H	-1.4727
16	G	H	-1.3339
17	G	H	-1.0499
18	S	H	-0.9087
19	L	H	-0.4657
20	R	H	-1.2873
21	L	H	0.0000
22	S	H	-0.3126
23	C	H	0.0000
24	A	H	-0.1901
25	A	H	0.0000
26	S	H	-0.6575
27	G	H	-0.8136
28	F	H	-0.4448
29	T	H	-0.6976
30	F	H	0.0000
35	D	H	-2.0749
36	D	H	-2.3992
37	A	H	0.0000
38	W	H	0.0000
39	M	H	0.0000
40	S	H	0.0000
41	W	H	0.0000
42	V	H	0.0000
43	R	H	0.0000
44	Q	H	-0.7257
45	A	H	-1.1312
46	P	H	-0.9239
47	G	H	-1.3824
48	K	H	-2.0407
49	G	H	-1.1577
50	L	H	0.0000
51	E	H	-0.6194
52	W	H	0.0000
53	V	H	0.0000
54	A	H	0.0000
55	E	H	0.0000
56	I	H	0.0000
57	S	H	0.0000
58	T	H	0.0000
59	K	H	-3.0127
60	A	H	-1.9902
61	N	H	-2.0488
62	N	H	-2.4197
63	H	H	-1.7357
64	A	H	-0.8976
65	T	H	-0.0984
66	Y	H	-0.2484
67	Y	H	-0.9913
68	A	H	0.0000
69	E	H	-2.6434
70	S	H	-1.6910
71	V	H	0.0000
72	K	H	-2.5462
74	G	H	-1.7290
75	R	H	-1.5496
76	F	H	0.0000
77	T	H	-0.7062
78	I	H	0.0000
79	S	H	-0.3744
80	R	H	-1.0271
81	D	H	-1.2501
82	D	H	-1.8164
83	S	H	-1.3932
84	K	H	-2.0574
85	S	H	-1.2820
86	S	H	0.0000
87	V	H	0.0000
88	Y	H	-0.3896
89	L	H	0.0000
90	Q	H	-0.9361
91	M	H	0.0000
92	N	H	-1.1719
93	S	H	-1.1245
94	L	H	0.0000
95	R	H	-1.9431
96	A	H	-1.5373
97	E	H	-2.1224
98	D	H	0.0000
99	T	H	-0.5678
100	A	H	0.0000
101	V	H	0.1159
102	Y	H	0.0000
103	Y	H	0.0000
104	C	H	0.0000
105	T	H	0.0000
106	R	H	-0.3296
107	L	H	0.0000
108	A	H	0.1318
109	T	H	0.3639
110	W	H	1.2623
112	D	H	0.0000
113	W	H	0.5563
114	Y	H	0.3989
115	F	H	0.0000
116	D	H	-0.2743
117	V	H	-0.1121
118	W	H	0.0000
119	G	H	0.0000
120	Q	H	-1.5786
121	G	H	-0.7836
122	T	H	-0.2786
123	T	H	0.0953
124	V	H	0.0000
125	T	H	-0.0019
126	V	H	0.0000
127	S	H	-0.4668
128	S	H	-0.5485
1	D	L	-1.9007
2	I	L	0.0000
3	V	L	0.8164
4	L	L	0.0000
5	T	L	-0.5265
6	Q	L	0.0000
7	S	L	-0.5997
8	P	L	-0.4337
9	S	L	-0.6302
10	S	L	-0.7418
11	L	L	-0.4143
12	S	L	-0.7463
13	A	L	0.0000
14	S	L	-0.6841
15	V	L	0.2348
16	G	L	-0.6899
17	D	L	-1.7514
18	R	L	-2.2585
19	V	L	0.0000
20	T	L	-0.5868
21	I	L	0.0000
22	T	L	-0.8423
23	C	L	0.0000
24	R	L	-2.2234
25	A	L	0.0000
26	S	L	-0.7375
27	Q	L	-1.2330
28	S	L	-1.0198
29	V	L	0.0000
30	D	L	-1.2233
31	Y	L	-0.4789
34	D	L	-1.8321
35	G	L	-1.6258
36	D	L	-1.6464
37	S	L	-1.2062
38	Y	L	-0.3340
39	M	L	0.0000
40	N	L	0.0000
41	W	L	0.0000
42	Y	L	0.0000
43	Q	L	-0.6487
44	Q	L	0.0000
45	K	L	-1.5208
46	P	L	-1.1369
47	G	L	-1.7292
48	K	L	-2.6132
49	P	L	-1.5843
50	P	L	0.0000
51	K	L	-1.0778
52	L	L	0.0000
53	L	L	0.0000
54	I	L	0.0000
55	Y	L	-0.3235
56	A	L	-0.8362
57	A	L	0.0000
65	S	L	-1.2768
66	E	L	-1.7503
67	L	L	-0.6167
68	E	L	-0.6596
69	S	L	-0.5907
70	G	L	-0.4462
71	I	L	-0.1627
72	P	L	-0.1894
74	A	L	-0.1352
75	R	L	-0.5500
76	F	L	0.0000
77	S	L	-0.5841
78	G	L	-0.6874
79	S	L	-0.9525
80	G	L	-1.2433
83	S	L	-1.3914
84	G	L	-1.1618
85	T	L	-1.6501
86	D	L	-2.0943
87	F	L	0.0000
88	T	L	-0.7908
89	L	L	0.0000
90	T	L	-0.5947
91	I	L	0.0000
92	S	L	-1.1751
93	S	L	-1.0870
94	L	L	0.0000
95	Q	L	-0.5912
96	P	L	-0.6241
97	E	L	-1.4847
98	D	L	0.0000
99	F	L	0.1333
100	A	L	0.0000
101	T	L	-0.6009
102	Y	L	0.0000
103	Y	L	0.0000
104	C	L	0.0000
105	Q	L	0.0000
106	Q	L	0.0000
107	S	L	0.0000
108	N	L	-1.0316
109	E	L	-2.0024
114	D	L	-2.5882
115	P	L	-2.0500
116	F	L	0.0000
117	T	L	-0.4583
118	F	L	0.3115
119	G	L	0.0000
120	S	L	-0.4494
121	G	L	0.0000
122	T	L	0.0000
123	K	L	-1.1382
124	L	L	0.0000
125	E	L	-0.7344
126	I	L	-0.2354
127	K	L	-1.3634