| Chain sequence(s) |
A: YLPPTTPVAKVQSTDEYVYPTSLFCHAHTDRLLTVGHPFQDIVVNGKVLVPKVSGYQWRVFRLKFPDPNKFALPQKDFYDPEKERLVWRLRGLEIGRGGPLGKGTIGHPLFNKLGDTENPTEPVHEGADDRVAFSFDPKQTQLFIVGCEPPTGEHWDLAEPCPGLPPGACPPIQLVNSVIEDGDMCDIGFGNMNFKELQQDRSGVPLDIVSTRCKWPDFLKMTNEAYGDKMFFFGRREQVYARHFYRRAGPVGHPLPAAPPPSPLYIPPPPGSPYAVLPSYDYFGTPSGSLVSSDGQLFNRPFWLQRAQGNNNGVCWHNELFVTVVDNTRNTNFTISQQLCTLPVNVYDPSCFKNYLRHVEQFELSLIAQLCKVPLDPGVLAHINTMNPTILENWNLGFVPPKEREDPYKGLIFWEVDLTERFSQDLDQFALGRKFLYQ
input PDB |
| Selected Chain(s) | A |
| Distance of aggregation | 10 Å |
| FoldX usage | No |
| Dynamic mode | No |
| Automated mutations | No |
| Downloads | Download all the data |
| Simulation log |
[INFO] Logger: Verbosity set to: 2 - [INFO] (00:00:00)
[WARNING] runJob: Working directory already exists (possibly overwriting previous results -ow
to prevent this behavior) (00:00:00)
[INFO] runJob: Starting aggrescan3d job on: input.pdb with A chain(s) selected (00:00:00)
[INFO] runJob: Creating pdb object from: input.pdb (00:00:00)
[INFO] runJob: FoldX not utilized. Treating input pdb file as it was already optimized. (00:00:00)
[INFO] Analysis: Starting Aggrescan3D on folded.pdb (00:00:01)
[INFO] Main: Simulation completed successfully. (00:00:05)
|
The table below lists A3D score for protein residues. Residues with A3D score > 0.0000 are marked by yellow rows.
| residue index | residue name | chain | Aggrescan3D score | mutation |
|---|---|---|---|---|
| residue index | residue name | chain | Aggrescan3D score | |
| 1 | Y | A | 1.9503 | |
| 2 | L | A | 1.9744 | |
| 3 | P | A | 0.6530 | |
| 4 | P | A | 0.3650 | |
| 5 | T | A | 0.1159 | |
| 6 | T | A | 0.1311 | |
| 7 | P | A | 0.1673 | |
| 8 | V | A | 1.2107 | |
| 9 | A | A | 0.0197 | |
| 10 | K | A | -1.1701 | |
| 11 | V | A | -0.4369 | |
| 12 | Q | A | -1.5593 | |
| 13 | S | A | -1.6169 | |
| 14 | T | A | 0.0000 | |
| 15 | D | A | -2.4148 | |
| 16 | E | A | -2.4389 | |
| 17 | Y | A | 0.0000 | |
| 18 | V | A | 0.0000 | |
| 19 | Y | A | 0.4631 | |
| 20 | P | A | 0.1302 | |
| 21 | T | A | 0.1642 | |
| 22 | S | A | -0.0976 | |
| 23 | L | A | 0.0938 | |
| 24 | F | A | -0.0317 | |
| 25 | C | A | 0.0000 | |
| 26 | H | A | 0.0000 | |
| 27 | A | A | 0.0000 | |
| 28 | H | A | -1.2597 | |
| 29 | T | A | 0.0000 | |
| 30 | D | A | -2.8722 | |
| 31 | R | A | -2.6465 | |
| 32 | L | A | -0.7738 | |
| 33 | L | A | 1.1822 | |
| 34 | T | A | 1.3879 | |
| 35 | V | A | 1.8482 | |
| 36 | G | A | 0.0000 | |
| 37 | H | A | -0.1465 | |
| 38 | P | A | 0.0000 | |
| 39 | F | A | -0.3984 | |
| 40 | Q | A | -1.3918 | |
| 41 | D | A | -0.5376 | |
| 42 | I | A | 1.3499 | |
| 43 | V | A | 2.2666 | |
| 44 | V | A | 1.6734 | |
| 45 | N | A | -0.5123 | |
| 46 | G | A | -0.3555 | |
| 47 | K | A | -0.1243 | |
| 48 | V | A | 2.1960 | |
| 49 | L | A | 2.5273 | |
| 50 | V | A | 1.5115 | |
| 51 | P | A | 0.4228 | |
| 52 | K | A | -0.5297 | |
| 53 | V | A | 0.0000 | |
| 54 | S | A | 0.0000 | |
| 55 | G | A | 0.0000 | |
| 56 | Y | A | 0.0000 | |
| 57 | Q | A | 0.0000 | |
| 58 | W | A | 0.0000 | |
| 59 | R | A | 0.0000 | |
| 60 | V | A | 0.0000 | |
| 61 | F | A | 0.0000 | |
| 62 | R | A | 0.0000 | |
| 63 | L | A | 0.0000 | |
| 64 | K | A | -2.1275 | |
| 65 | F | A | 0.0000 | |
| 66 | P | A | 0.0000 | |
| 67 | D | A | -1.4730 | |
| 68 | P | A | 0.0000 | |
| 69 | N | A | -1.2645 | |
| 70 | K | A | -1.8083 | |
| 71 | F | A | -0.6648 | |
| 72 | A | A | -0.5860 | |
| 73 | L | A | -0.8594 | |
| 74 | P | A | -1.2481 | |
| 75 | Q | A | -2.4796 | |
| 76 | K | A | -3.0942 | |
| 77 | D | A | -2.9869 | |
| 78 | F | A | -1.6310 | |
| 79 | Y | A | -1.9212 | |
| 80 | D | A | -2.7705 | |
| 81 | P | A | -2.3619 | |
| 82 | E | A | -3.0819 | |
| 83 | K | A | -3.4489 | |
| 84 | E | A | -2.5150 | |
| 85 | R | A | -1.3272 | |
| 86 | L | A | 0.0000 | |
| 87 | V | A | 0.0000 | |
| 88 | W | A | 0.0000 | |
| 89 | R | A | 0.0000 | |
| 90 | L | A | 0.0000 | |
| 91 | R | A | -0.6512 | |
| 92 | G | A | 0.0000 | |
| 93 | L | A | 0.0000 | |
| 94 | E | A | -0.9713 | |
| 95 | I | A | 0.0000 | |
| 96 | G | A | -1.3814 | |
| 97 | R | A | 0.0000 | |
| 98 | G | A | -0.7419 | |
| 99 | G | A | -0.5469 | |
| 100 | P | A | -0.4098 | |
| 101 | L | A | 0.0372 | |
| 102 | G | A | -0.1930 | |
| 103 | K | A | -0.5771 | |
| 104 | G | A | 0.0000 | |
| 105 | T | A | -0.4279 | |
| 106 | I | A | 0.0000 | |
| 107 | G | A | 0.1295 | |
| 108 | H | A | 0.0000 | |
| 109 | P | A | 0.3873 | |
| 110 | L | A | 0.2359 | |
| 111 | F | A | 0.0000 | |
| 112 | N | A | -1.1635 | |
| 113 | K | A | -0.4996 | |
| 114 | L | A | 0.0000 | |
| 115 | G | A | 0.0000 | |
| 116 | D | A | -1.4365 | |
| 117 | T | A | -0.8910 | |
| 118 | E | A | -1.9377 | |
| 119 | N | A | -2.3527 | |
| 120 | P | A | -1.9178 | |
| 121 | T | A | -1.5538 | |
| 122 | E | A | -2.1396 | |
| 123 | P | A | -0.9857 | |
| 124 | V | A | -0.8031 | |
| 125 | H | A | -1.5859 | |
| 126 | E | A | -2.5004 | |
| 127 | G | A | -2.1378 | |
| 128 | A | A | -1.5790 | |
| 129 | D | A | -2.4769 | |
| 130 | D | A | -2.1557 | |
| 131 | R | A | -1.1917 | |
| 132 | V | A | 0.1836 | |
| 133 | A | A | 0.4164 | |
| 134 | F | A | 0.2551 | |
| 135 | S | A | -0.0788 | |
| 136 | F | A | 0.0000 | |
| 137 | D | A | -0.6718 | |
| 138 | P | A | 0.0000 | |
| 139 | K | A | 0.0000 | |
| 140 | Q | A | 0.0000 | |
| 141 | T | A | 0.0000 | |
| 142 | Q | A | 0.0000 | |
| 143 | L | A | 0.0000 | |
| 144 | F | A | 0.0000 | |
| 145 | I | A | 0.0000 | |
| 146 | V | A | 0.0000 | |
| 147 | G | A | 0.0000 | |
| 148 | C | A | 0.0000 | |
| 149 | E | A | -0.5610 | |
| 150 | P | A | 0.0000 | |
| 151 | P | A | 0.0000 | |
| 152 | T | A | 0.0000 | |
| 153 | G | A | 0.0000 | |
| 154 | E | A | -0.2297 | |
| 155 | H | A | 0.0000 | |
| 156 | W | A | 1.1122 | |
| 157 | D | A | 0.2731 | |
| 158 | L | A | 0.7569 | |
| 159 | A | A | 0.1504 | |
| 160 | E | A | -1.4513 | |
| 161 | P | A | -0.2098 | |
| 162 | C | A | 0.1889 | |
| 163 | P | A | -0.1699 | |
| 164 | G | A | -0.0763 | |
| 165 | L | A | 0.5846 | |
| 166 | P | A | -0.1160 | |
| 167 | P | A | -0.3415 | |
| 168 | G | A | -0.4196 | |
| 169 | A | A | -0.0214 | |
| 170 | C | A | 0.6613 | |
| 171 | P | A | 0.5117 | |
| 172 | P | A | 0.7606 | |
| 173 | I | A | 1.9412 | |
| 174 | Q | A | 0.8119 | |
| 175 | L | A | 1.4663 | |
| 176 | V | A | 0.8271 | |
| 177 | N | A | -0.3212 | |
| 178 | S | A | 0.0353 | |
| 179 | V | A | 0.4428 | |
| 180 | I | A | 0.0000 | |
| 181 | E | A | 0.3805 | |
| 182 | D | A | 0.0847 | |
| 183 | G | A | -0.1560 | |
| 184 | D | A | -0.5586 | |
| 185 | M | A | 0.0000 | |
| 186 | C | A | 0.0000 | |
| 187 | D | A | 0.0000 | |
| 188 | I | A | 0.0000 | |
| 189 | G | A | 0.1420 | |
| 190 | F | A | 0.0553 | |
| 191 | G | A | -0.1016 | |
| 192 | N | A | -0.2779 | |
| 193 | M | A | -0.1572 | |
| 194 | N | A | 0.0000 | |
| 195 | F | A | 0.0000 | |
| 196 | K | A | -3.4433 | |
| 197 | E | A | -2.6642 | |
| 198 | L | A | -1.2674 | |
| 199 | Q | A | -2.5701 | |
| 200 | Q | A | -3.3481 | |
| 201 | D | A | -3.6108 | |
| 202 | R | A | -3.3585 | |
| 203 | S | A | 0.0000 | |
| 204 | G | A | 0.0000 | |
| 205 | V | A | 0.0000 | |
| 206 | P | A | 0.0000 | |
| 207 | L | A | 0.2593 | |
| 208 | D | A | 0.0000 | |
| 209 | I | A | 0.0000 | |
| 210 | V | A | -1.3952 | |
| 211 | S | A | -1.8565 | |
| 212 | T | A | -1.4781 | |
| 213 | R | A | -2.1689 | |
| 214 | C | A | 0.0000 | |
| 215 | K | A | 0.0000 | |
| 216 | W | A | -0.1759 | |
| 217 | P | A | 0.0000 | |
| 218 | D | A | 0.0000 | |
| 219 | F | A | 0.3180 | |
| 220 | L | A | 0.5390 | |
| 221 | K | A | -1.2315 | |
| 222 | M | A | 0.0000 | |
| 223 | T | A | -0.9405 | |
| 224 | N | A | -1.5506 | |
| 225 | E | A | -1.3082 | |
| 226 | A | A | -0.6825 | |
| 227 | Y | A | -0.4571 | |
| 228 | G | A | 0.0000 | |
| 229 | D | A | 0.0000 | |
| 230 | K | A | -0.6986 | |
| 231 | M | A | 0.0000 | |
| 232 | F | A | 0.0000 | |
| 233 | F | A | -0.1420 | |
| 234 | F | A | 0.0263 | |
| 235 | G | A | -0.8794 | |
| 236 | R | A | -2.5724 | |
| 237 | R | A | -2.7167 | |
| 238 | E | A | -2.0165 | |
| 239 | Q | A | -0.0832 | |
| 240 | V | A | 1.5169 | |
| 241 | Y | A | 1.2309 | |
| 242 | A | A | 0.1304 | |
| 243 | R | A | -1.1992 | |
| 244 | H | A | -1.1207 | |
| 245 | F | A | -0.1164 | |
| 246 | Y | A | 0.0000 | |
| 247 | R | A | 0.0000 | |
| 248 | R | A | -0.4209 | |
| 249 | A | A | -1.2494 | |
| 250 | G | A | -0.9853 | |
| 251 | P | A | -0.7131 | |
| 252 | V | A | -0.4371 | |
| 253 | G | A | -0.8947 | |
| 254 | H | A | -1.1210 | |
| 255 | P | A | -0.4421 | |
| 256 | L | A | 0.5059 | |
| 257 | P | A | 0.0573 | |
| 258 | A | A | 0.1352 | |
| 259 | A | A | 0.2342 | |
| 260 | P | A | -0.2416 | |
| 261 | P | A | 0.0588 | |
| 262 | P | A | 0.1220 | |
| 263 | S | A | 0.6981 | |
| 264 | P | A | 0.7247 | |
| 265 | L | A | 1.9562 | |
| 266 | Y | A | 1.9070 | |
| 267 | I | A | 2.1801 | |
| 268 | P | A | 1.1714 | |
| 269 | P | A | 0.7699 | |
| 270 | P | A | -0.1454 | |
| 271 | P | A | -0.4938 | |
| 272 | G | A | -0.3307 | |
| 273 | S | A | 0.1902 | |
| 274 | P | A | 0.6017 | |
| 275 | Y | A | 1.8049 | |
| 276 | A | A | 1.4212 | |
| 277 | V | A | 2.3733 | |
| 278 | L | A | 2.0481 | |
| 279 | P | A | 0.6521 | |
| 280 | S | A | 0.0000 | |
| 281 | Y | A | 0.3794 | |
| 282 | D | A | -0.2088 | |
| 283 | Y | A | 1.1365 | |
| 284 | F | A | 0.8000 | |
| 285 | G | A | 0.1598 | |
| 286 | T | A | 0.0000 | |
| 287 | P | A | 0.0000 | |
| 288 | S | A | 0.0000 | |
| 289 | G | A | 0.0000 | |
| 290 | S | A | 0.9481 | |
| 291 | L | A | 1.6513 | |
| 292 | V | A | 0.6766 | |
| 293 | S | A | -0.1423 | |
| 294 | S | A | -0.9630 | |
| 295 | D | A | -1.8377 | |
| 296 | G | A | 0.0000 | |
| 297 | Q | A | 0.0000 | |
| 298 | L | A | -1.1091 | |
| 299 | F | A | 0.0000 | |
| 300 | N | A | -1.6701 | |
| 301 | R | A | -1.9208 | |
| 302 | P | A | -0.9864 | |
| 303 | F | A | -0.1958 | |
| 304 | W | A | -0.5279 | |
| 305 | L | A | 0.0000 | |
| 306 | Q | A | -2.0857 | |
| 307 | R | A | -2.9272 | |
| 308 | A | A | 0.0000 | |
| 309 | Q | A | -1.6569 | |
| 310 | G | A | -1.4243 | |
| 311 | N | A | -1.4065 | |
| 312 | N | A | 0.0000 | |
| 313 | N | A | 0.0000 | |
| 314 | G | A | 0.0000 | |
| 315 | V | A | 0.0000 | |
| 316 | C | A | 0.0000 | |
| 317 | W | A | 0.0000 | |
| 318 | H | A | -0.9482 | |
| 319 | N | A | -0.8919 | |
| 320 | E | A | -1.0540 | |
| 321 | L | A | 0.0000 | |
| 322 | F | A | 0.0000 | |
| 323 | V | A | 0.0000 | |
| 324 | T | A | 0.0000 | |
| 325 | V | A | 0.0000 | |
| 326 | V | A | 0.0000 | |
| 327 | D | A | 0.0000 | |
| 328 | N | A | 0.0000 | |
| 329 | T | A | 0.0000 | |
| 330 | R | A | -0.3257 | |
| 331 | N | A | 0.0000 | |
| 332 | T | A | -0.0987 | |
| 333 | N | A | 0.4810 | |
| 334 | F | A | 1.5755 | |
| 335 | T | A | 0.7989 | |
| 336 | I | A | 0.4387 | |
| 337 | S | A | -0.9477 | |
| 338 | Q | A | -1.7238 | |
| 339 | Q | A | -1.3109 | |
| 340 | L | A | 0.6777 | |
| 341 | C | A | 0.5271 | |
| 342 | T | A | 0.4907 | |
| 343 | L | A | 1.0658 | |
| 344 | P | A | 1.0428 | |
| 345 | V | A | 1.7669 | |
| 346 | N | A | 0.6736 | |
| 347 | V | A | 2.1015 | |
| 348 | Y | A | 1.8216 | |
| 349 | D | A | 0.2271 | |
| 350 | P | A | -0.4680 | |
| 351 | S | A | -0.2621 | |
| 352 | C | A | 0.0000 | |
| 353 | F | A | -0.7084 | |
| 354 | K | A | -1.7622 | |
| 355 | N | A | -1.7391 | |
| 356 | Y | A | -0.0875 | |
| 357 | L | A | 0.5960 | |
| 358 | R | A | 0.8977 | |
| 359 | H | A | 0.0000 | |
| 360 | V | A | 1.3896 | |
| 361 | E | A | 0.0000 | |
| 362 | Q | A | -0.0283 | |
| 363 | F | A | 0.0000 | |
| 364 | E | A | -1.9421 | |
| 365 | L | A | 0.0000 | |
| 366 | S | A | -0.6659 | |
| 367 | L | A | 0.0000 | |
| 368 | I | A | 0.0000 | |
| 369 | A | A | 0.0000 | |
| 370 | Q | A | 0.0000 | |
| 371 | L | A | 0.0000 | |
| 372 | C | A | 0.0000 | |
| 373 | K | A | -0.2799 | |
| 374 | V | A | 0.0000 | |
| 375 | P | A | -1.3310 | |
| 376 | L | A | -1.7654 | |
| 377 | D | A | -2.0331 | |
| 378 | P | A | -1.0632 | |
| 379 | G | A | -1.0215 | |
| 380 | V | A | -0.9326 | |
| 381 | L | A | -0.5413 | |
| 382 | A | A | -0.6589 | |
| 383 | H | A | -0.8516 | |
| 384 | I | A | 0.0000 | |
| 385 | N | A | -1.3892 | |
| 386 | T | A | -0.5723 | |
| 387 | M | A | -0.3297 | |
| 388 | N | A | -0.8657 | |
| 389 | P | A | -1.2787 | |
| 390 | T | A | -1.6128 | |
| 391 | I | A | 0.0000 | |
| 392 | L | A | -1.5955 | |
| 393 | E | A | -3.0366 | |
| 394 | N | A | -2.8292 | |
| 395 | W | A | -1.6272 | |
| 396 | N | A | -1.3439 | |
| 397 | L | A | -0.3135 | |
| 398 | G | A | 0.4561 | |
| 399 | F | A | 2.4019 | |
| 400 | V | A | 1.8281 | |
| 401 | P | A | 0.0393 | |
| 402 | P | A | -2.0205 | |
| 403 | K | A | -3.5350 | |
| 404 | E | A | -4.0741 | |
| 405 | R | A | -4.5884 | |
| 406 | E | A | -4.0743 | |
| 407 | D | A | -2.9815 | |
| 408 | P | A | -1.8309 | |
| 409 | Y | A | -0.9755 | |
| 410 | K | A | -2.0953 | |
| 411 | G | A | -0.6228 | |
| 412 | L | A | 0.6818 | |
| 413 | I | A | 1.5901 | |
| 414 | F | A | 0.0000 | |
| 415 | W | A | -0.3900 | |
| 416 | E | A | -1.6573 | |
| 417 | V | A | 0.0000 | |
| 418 | D | A | -2.9241 | |
| 419 | L | A | 0.0000 | |
| 420 | T | A | -2.0434 | |
| 421 | E | A | -2.7611 | |
| 422 | R | A | -2.5954 | |
| 423 | F | A | -1.2775 | |
| 424 | S | A | -1.4507 | |
| 425 | Q | A | -1.8761 | |
| 426 | D | A | -2.8923 | |
| 427 | L | A | -1.9967 | |
| 428 | D | A | -2.7782 | |
| 429 | Q | A | -2.6091 | |
| 430 | F | A | -1.4382 | |
| 431 | A | A | -0.9053 | |
| 432 | L | A | 0.0000 | |
| 433 | G | A | 0.0000 | |
| 434 | R | A | -1.5971 | |
| 435 | K | A | -0.7419 | |
| 436 | F | A | 0.1384 | |
| 437 | L | A | 1.0261 | |
| 438 | Y | A | 0.8185 | |
| 439 | Q | A | -0.2729 |
ALA alanine
ARG arginine
ASN asparagine
ASP aspartic acid
CYS cysteine
GLN glutamine
GLU glutamic acid
GLY glycine
HIS histidine
ILE isoleucine
LEU leucine
LYS lysine
MET methionine
PHE phenylalanine
PRO proline
SER serine
THR threonine
TRP tryptophan
TYR tyrosine
VAL valine