Project name: fd1ceab1bbefec0

Chain sequence(s)	I: QSVLTQPPSVSAAPGQKVAISCSGSTSNIGDNFVSWYQQFPGTAPKLLLYDDARRPSGIPDRFSGSKSGTSATLGITGLQTGDEAVYFCSTWDNSLNVVLFGGGTKLTVL; G: EVQLVESGGGLVQPGRSLTLSCGASGFTFEDYAMHWVRQAPGKGLEWVSGIDWNSGVIGYADSVKGRFIISRDNAKNSLYLHMRSLTAEDTALYYCAKDVYSESGSGSYYDYWGQGTLVTVSS
Selected Chain(s)	G,I
Distance of aggregation	10 Å
FoldX usage	Yes
Dynamic mode	No
Automated mutations	No

Simulation log

[INFO]       Logger:   Verbosity set to: 2 - [INFO]                                                (00:00:00)
[WARNING]    runJob:   Working directory already exists (possibly overwriting previous results -ow 
                       to prevent this behavior)                                                   (00:00:00)
[INFO]       runJob:   Starting aggrescan3d job on: input.pdb with all chain(s) selected           (00:00:00)
[INFO]       runJob:   Creating pdb object from: input.pdb                                         (00:00:00)
[INFO]       FoldX:    Starting FoldX energy minimalization                                        (00:00:00)
[INFO]       Analysis: Starting Aggrescan3D on folded.pdb                                          (00:01:12)
[INFO]       Main:     Simulation completed successfully.                                          (00:01:13)

• Minimal score value: -2.827
• Maximal score value: 1.5564
• Average score: -0.5152
• Total score value: -120.0411

The table below lists A3D score for protein residues. Residues with A3D score > 0.0000 are marked by yellow rows.

residue index	residue name	chain	Aggrescan3D score	mutation
1	E	G	-2.0616
2	V	G	-1.1766
3	Q	G	-1.3083
4	L	G	0.0000
5	V	G	1.0050
6	E	G	0.1215
7	S	G	0.1100
8	G	G	-0.3087
9	G	G	0.2889
11	G	G	0.7967
12	L	G	1.4919
13	V	G	-0.1638
14	Q	G	-1.4651
15	P	G	-1.5454
16	G	G	-2.0931
17	R	G	-2.8270
18	S	G	-1.9398
19	L	G	-0.7288
20	T	G	-0.0979
21	L	G	0.0000
22	S	G	0.2998
23	C	G	0.0000
24	G	G	0.0480
25	A	G	0.0000
26	S	G	-0.7908
27	G	G	-1.2244
28	F	G	-0.8733
29	T	G	-0.9156
30	F	G	0.0000
35	E	G	-1.9901
36	D	G	-1.7615
37	Y	G	-0.3457
38	A	G	0.0000
39	M	G	0.0000
40	H	G	0.0000
41	W	G	0.0000
42	V	G	0.0000
43	R	G	0.0000
44	Q	G	-0.7670
45	A	G	-1.0038
46	P	G	-0.9667
47	G	G	-1.4766
48	K	G	-2.3328
49	G	G	-1.5332
50	L	G	0.0000
51	E	G	-1.2340
52	W	G	0.0000
53	V	G	0.0000
54	S	G	0.0000
55	G	G	0.0000
56	I	G	0.0000
57	D	G	-0.5189
58	W	G	-0.6943
59	N	G	-1.4136
62	S	G	-0.5576
63	G	G	-0.0821
64	V	G	1.1471
65	I	G	0.4374
66	G	G	0.0448
67	Y	G	-0.6680
68	A	G	-1.5870
69	D	G	-2.6128
70	S	G	-1.8738
71	V	G	0.0000
72	K	G	-2.5174
74	G	G	-1.7482
75	R	G	-1.7327
76	F	G	0.0000
77	I	G	0.6027
78	I	G	0.0000
79	S	G	0.2494
80	R	G	-0.7868
81	D	G	-1.5728
82	N	G	-1.9002
83	A	G	-1.4187
84	K	G	-2.3150
85	N	G	-1.7512
86	S	G	-0.8457
87	L	G	0.0000
88	Y	G	0.7929
89	L	G	0.0000
90	H	G	-0.1105
91	M	G	0.0000
92	R	G	-2.4091
93	S	G	-1.8516
94	L	G	0.0000
95	T	G	-1.3340
96	A	G	-1.0157
97	E	G	-1.8297
98	D	G	0.0000
99	T	G	-0.1539
100	A	G	0.0000
101	L	G	0.5306
102	Y	G	0.0000
103	Y	G	0.0000
104	C	G	0.0000
105	A	G	0.0000
106	K	G	0.0000
107	D	G	0.0000
108	V	G	0.4078
109	Y	G	0.3447
110	S	G	-0.6870
111	E	G	-1.5459
111A	S	G	0.0000
112B	G	G	-1.1534
112A	S	G	-0.5614
112	G	G	0.1349
113	S	G	0.2532
114	Y	G	0.5220
115	Y	G	0.0000
116	D	G	-0.2413
117	Y	G	-0.3612
118	W	G	-0.3034
119	G	G	0.0000
120	Q	G	-1.0320
121	G	G	-0.1364
122	T	G	0.3659
123	L	G	1.4317
124	V	G	0.0000
125	T	G	0.5667
126	V	G	0.0000
127	S	G	-0.2816
128	S	G	-0.4792
1	Q	I	-0.8981
2	S	I	0.1994
3	V	I	1.2885
4	L	I	0.0000
5	T	I	0.0321
6	Q	I	-0.4132
7	P	I	-0.5301
8	P	I	-0.6293
9	S	I	-0.5795
11	V	I	-0.1802
12	S	I	-0.1078
13	A	I	-0.5957
14	A	I	-0.6415
15	P	I	-1.3579
16	G	I	-1.9007
17	Q	I	-2.4430
18	K	I	-2.4737
19	V	I	0.0000
20	A	I	-0.4744
21	I	I	0.0000
22	S	I	-0.3834
23	C	I	0.0000
24	S	I	-0.1494
25	G	I	-0.0312
26	S	I	-0.4443
27	T	I	-0.9394
28	S	I	-1.0376
29	N	I	0.0000
30	I	I	0.0000
35	G	I	-1.3113
36	D	I	-1.8814
37	N	I	0.0000
38	F	I	1.2268
39	V	I	0.0000
40	S	I	0.0000
41	W	I	0.0000
42	Y	I	0.0000
43	Q	I	-0.4093
44	Q	I	0.0000
45	F	I	0.7515
46	P	I	0.1150
47	G	I	-0.3343
48	T	I	-0.2904
49	A	I	-0.5240
50	P	I	0.0000
51	K	I	-1.2638
52	L	I	0.0000
53	L	I	0.0000
54	L	I	0.0000
55	Y	I	-0.5919
56	D	I	-0.4103
57	D	I	-0.5822
65	A	I	-1.1398
66	R	I	-2.5528
67	R	I	-2.1142
68	P	I	-1.0607
69	S	I	-0.9668
70	G	I	-0.8349
71	I	I	-1.1830
72	P	I	-1.2836
74	D	I	-2.4008
75	R	I	-1.5560
76	F	I	0.0000
77	S	I	-1.0334
78	G	I	-0.6092
79	S	I	-0.7844
80	K	I	-0.5323
83	S	I	-0.7518
84	G	I	-0.8619
85	T	I	-0.8665
86	S	I	-0.6602
87	A	I	0.0000
88	T	I	-0.3962
89	L	I	0.0000
90	G	I	0.0000
91	I	I	0.0000
92	T	I	-1.7895
93	G	I	-1.6059
94	L	I	0.0000
95	Q	I	-1.8664
96	T	I	-0.8809
97	G	I	-0.9302
98	D	I	-0.9140
99	E	I	-0.6885
100	A	I	0.0000
101	V	I	0.0116
102	Y	I	0.0000
103	F	I	0.0000
104	C	I	0.0000
105	S	I	0.0000
106	T	I	0.0000
107	W	I	-0.2128
108	D	I	0.0000
109	N	I	-1.7473
110	S	I	-1.1439
113	L	I	-0.8475
114	N	I	-1.2167
115	V	I	-0.5927
116	V	I	-0.0864
117	L	I	0.0000
118	F	I	0.0000
119	G	I	0.0000
120	G	I	-0.8536
121	G	I	-0.8445
122	T	I	0.0000
123	K	I	-0.7986
124	L	I	0.0000
125	T	I	-0.2607
126	V	I	0.4776
127	L	I	1.5564