Project name: HAH6IGF2

Chain sequence(s)	A: AMYPYDVPDYAGSGGSQLQLVESGGGLVQPGGSLRLSCAASGFSLDPYVIGWFRQAPGKEREGVSCITSRAASRTSVDSVNERFTISRDNAKNTVDLHINNLKPEDSGVYYCAAVPPAKLPLFSLCRSLPAKYDYWGQGTQVTVSSAHHSEDPSGSGGSGSGGSGSGASAYRPSRTLCGGELVDTLQLVCGDRGFYFSRPASRVSRRPRGIVEECCFRSCDLALLETYCATPAKSEAAALEHHHHHH
Selected Chain(s)	A
Distance of aggregation	10 Å
FoldX usage	Yes
Dynamic mode	No
Automated mutations	No

Simulation log

[INFO]       Logger:   Verbosity set to: 2 - [INFO]                                                (00:00:00)
[WARNING]    runJob:   Working directory already exists (possibly overwriting previous results -ow 
                       to prevent this behavior)                                                   (00:00:00)
[INFO]       runJob:   Starting aggrescan3d job on: input.pdb with A chain(s) selected             (00:00:00)
[INFO]       runJob:   Creating pdb object from: input.pdb                                         (00:00:00)
[INFO]       FoldX:    Starting FoldX energy minimalization                                        (00:00:00)
[INFO]       Analysis: Starting Aggrescan3D on folded.pdb                                          (00:02:31)
[INFO]       Main:     Simulation completed successfully.                                          (00:02:33)

• Minimal score value: -3.4033
• Maximal score value: 1.8415
• Average score: -0.8417
• Total score value: -207.8963

The table below lists A3D score for protein residues. Residues with A3D score > 0.0000 are marked by yellow rows.

residue index	residue name	chain	Aggrescan3D score	mutation
1	A	A	0.9125
2	M	A	1.8415
3	Y	A	1.8328
4	P	A	1.0457
5	Y	A	1.3655
6	D	A	-0.5293
7	V	A	0.8875
8	P	A	-0.1141
9	D	A	-1.1028
10	Y	A	0.5331
11	A	A	-0.2394
12	G	A	-0.8367
13	S	A	-0.7597
14	G	A	-1.1847
15	G	A	-1.2982
16	S	A	-1.3249
17	Q	A	-1.6206
18	L	A	0.0000
19	Q	A	-0.8045
20	L	A	0.0000
21	V	A	0.0000
22	E	A	0.0000
23	S	A	0.0000
24	G	A	-1.5565
25	G	A	-0.9765
26	G	A	-0.1671
27	L	A	0.2924
28	V	A	0.0000
29	Q	A	-1.7587
30	P	A	-1.8471
31	G	A	-1.8719
32	G	A	-1.4277
33	S	A	-1.4709
34	L	A	-0.9426
35	R	A	-1.6700
36	L	A	0.0000
37	S	A	0.0000
38	C	A	0.0000
39	A	A	0.0000
40	A	A	0.0000
41	S	A	0.0000
42	G	A	-0.4256
43	F	A	0.2691
44	S	A	-0.1553
45	L	A	0.0000
46	D	A	-1.3473
47	P	A	-0.7224
48	Y	A	-0.4004
49	V	A	0.0000
50	I	A	0.0000
51	G	A	0.0000
52	W	A	0.0000
53	F	A	0.0000
54	R	A	-1.2732
55	Q	A	-1.9533
56	A	A	-1.9211
57	P	A	-1.3780
58	G	A	-1.9202
59	K	A	-3.2733
60	E	A	-3.4033
61	R	A	-2.5413
62	E	A	-1.8735
63	G	A	0.0000
64	V	A	0.0000
65	S	A	0.0000
66	C	A	0.0000
67	I	A	0.0000
68	T	A	-0.5531
69	S	A	0.0000
70	R	A	-2.5373
71	A	A	-1.2932
72	A	A	-1.3682
73	S	A	-1.4154
74	R	A	-2.1213
75	T	A	-1.1306
76	S	A	-0.1239
77	V	A	1.1519
78	D	A	0.1513
79	S	A	-0.2458
80	V	A	-0.2459
81	N	A	-1.1670
82	E	A	-2.1716
83	R	A	-1.7530
84	F	A	0.0000
85	T	A	-0.7745
86	I	A	0.0000
87	S	A	-0.4208
88	R	A	-1.5425
89	D	A	-1.6908
90	N	A	-2.3865
91	A	A	-2.0434
92	K	A	-2.7372
93	N	A	-1.8730
94	T	A	0.0000
95	V	A	0.0000
96	D	A	-0.8620
97	L	A	0.0000
98	H	A	-1.2047
99	I	A	0.0000
100	N	A	-2.0797
101	N	A	-2.2494
102	L	A	0.0000
103	K	A	-2.4774
104	P	A	-1.9229
105	E	A	-2.3054
106	D	A	0.0000
107	S	A	-1.0887
108	G	A	-1.0185
109	V	A	-0.5150
110	Y	A	0.0000
111	Y	A	-0.3595
112	C	A	0.0000
113	A	A	0.0000
114	A	A	0.0000
115	V	A	0.0000
116	P	A	-0.6443
117	P	A	-0.2542
118	A	A	-0.2975
119	K	A	-1.1125
120	L	A	0.0000
121	P	A	0.4272
122	L	A	1.5470
123	F	A	1.1101
124	S	A	0.6994
125	L	A	0.6708
126	C	A	0.0000
127	R	A	-0.4530
128	S	A	-0.3689
129	L	A	-0.1246
130	P	A	-0.4748
131	A	A	-0.3984
132	K	A	-1.0692
133	Y	A	0.0000
134	D	A	-1.2088
135	Y	A	-0.3822
136	W	A	-0.1056
137	G	A	-0.4557
138	Q	A	-1.1175
139	G	A	0.0000
140	T	A	0.0000
141	Q	A	-1.0968
142	V	A	0.0000
143	T	A	-0.6252
144	V	A	0.0000
145	S	A	-0.9918
146	S	A	-1.1154
147	A	A	-0.9440
148	H	A	-2.0192
149	H	A	-2.3079
150	S	A	-2.4613
151	E	A	-3.4015
152	D	A	-3.1620
153	P	A	-2.0231
154	S	A	-1.4920
155	G	A	-1.5012
156	S	A	-0.9197
157	G	A	-1.1055
158	G	A	-1.0833
159	S	A	-0.9428
160	G	A	-1.0714
161	S	A	-0.9136
162	G	A	-1.0861
163	G	A	-1.0641
164	S	A	-0.9188
165	G	A	-1.0000
166	S	A	-0.7860
167	G	A	-0.7576
168	A	A	-0.3260
169	S	A	-0.4923
170	A	A	-0.4848
171	Y	A	-0.8042
172	R	A	-2.2038
173	P	A	-1.7576
174	S	A	-2.0030
175	R	A	-2.3001
176	T	A	-1.1227
177	L	A	0.0000
178	C	A	-0.3965
179	G	A	-0.9740
180	G	A	-1.6463
181	E	A	-2.4632
182	L	A	0.0000
183	V	A	0.0000
184	D	A	-2.0676
185	T	A	-0.7327
186	L	A	0.0000
187	Q	A	-1.0006
188	L	A	0.7041
189	V	A	0.1677
190	C	A	0.0000
191	G	A	-1.3440
192	D	A	-2.6127
193	R	A	-2.0809
194	G	A	-1.4301
195	F	A	0.0000
196	Y	A	-0.0345
197	F	A	0.0000
198	S	A	-1.2496
199	R	A	-1.9262
200	P	A	-1.5691
201	A	A	-1.7761
202	S	A	-1.3911
203	R	A	-1.6912
204	V	A	0.0957
205	S	A	-1.4553
206	R	A	-2.8712
207	R	A	-3.2483
208	P	A	-2.6013
209	R	A	-2.5681
210	G	A	-1.2888
211	I	A	0.0000
212	V	A	0.2692
213	E	A	-0.2245
214	E	A	-0.6096
215	C	A	0.0000
216	C	A	0.1935
217	F	A	1.0435
218	R	A	-1.3702
219	S	A	-1.4239
220	C	A	0.0000
221	D	A	-1.5606
222	L	A	-0.0670
223	A	A	-0.0281
224	L	A	-0.0387
225	L	A	0.0000
226	E	A	-0.4217
227	T	A	-0.2310
228	Y	A	0.0000
229	C	A	-0.6694
230	A	A	-0.7945
231	T	A	-0.6811
232	P	A	-1.1951
233	A	A	-1.3256
234	K	A	-2.3082
235	S	A	-1.9117
236	E	A	-2.0161
237	A	A	-1.0210
238	A	A	-0.9786
239	A	A	-0.6652
240	L	A	-0.3412
241	E	A	-2.2333
242	H	A	-2.5374
243	H	A	-2.7257
244	H	A	-2.9628
245	H	A	-3.0740
246	H	A	-2.6257
247	H	A	-2.1242