Project name: fe000c452e07cde

Chain sequence(s)	H: EVQLVESGGGLVQPGGSLKLSCAASGFTFNTYAMNWVRQASGKGLEWVGRIRSKSNNYATYYADSVKDRFTISRDDSKNTAYLQMNSLKTEDTAVYYCVRGLLRYRFFDVWGQGTTVTVSS; L: DIVMTQSPLSLPVTPGEPASISCRSSKSLLHSNGNTYLYWFLQKPGQSPQLLIYRMSNLASGVPDRFSGSGSGTDFTLKISRVEAEDVGVYYCMQHLEYPFTFGGGTKVEIK
Selected Chain(s)	H,L
Distance of aggregation	10 Å
FoldX usage	Yes
Dynamic mode	No
Automated mutations	No

Simulation log

[INFO]       Logger:   Verbosity set to: 2 - [INFO]                                                (00:00:00)
[WARNING]    runJob:   Working directory already exists (possibly overwriting previous results -ow 
                       to prevent this behavior)                                                   (00:00:00)
[INFO]       runJob:   Starting aggrescan3d job on: input.pdb with all chain(s) selected           (00:00:00)
[INFO]       runJob:   Creating pdb object from: input.pdb                                         (00:00:00)
[INFO]       FoldX:    Starting FoldX energy minimalization                                        (00:00:00)
[INFO]       Analysis: Starting Aggrescan3D on folded.pdb                                          (00:01:17)
[INFO]       Main:     Simulation completed successfully.                                          (00:01:19)

• Minimal score value: -2.798
• Maximal score value: 1.2742
• Average score: -0.5903
• Total score value: -137.5336

The table below lists A3D score for protein residues. Residues with A3D score > 0.0000 are marked by yellow rows.

residue index	residue name	chain	Aggrescan3D score	mutation
1	E	H	-1.7575
2	V	H	-0.5751
3	Q	H	-0.4894
4	L	H	0.0000
5	V	H	1.2742
6	E	H	0.0000
7	S	H	-0.3814
8	G	H	-0.7109
9	G	H	-0.3630
11	G	H	0.4024
12	L	H	1.1651
13	V	H	-0.0205
14	Q	H	-1.3204
15	P	H	-1.6161
16	G	H	-1.4180
17	G	H	-1.1087
18	S	H	-1.0483
19	L	H	-0.8544
20	K	H	-1.8254
21	L	H	0.0000
22	S	H	-0.2660
23	C	H	0.0000
24	A	H	-0.0313
25	A	H	-0.2014
26	S	H	-0.4439
27	G	H	-0.8437
28	F	H	-0.3883
29	T	H	-0.2914
30	F	H	0.0000
35	N	H	-1.5332
36	T	H	-0.6778
37	Y	H	-0.2006
38	A	H	0.0000
39	M	H	0.0000
40	N	H	0.0000
41	W	H	0.0000
42	V	H	0.0000
43	R	H	0.0000
44	Q	H	-0.7882
45	A	H	-1.1321
46	S	H	-0.9536
47	G	H	-1.4360
48	K	H	-2.2614
49	G	H	-1.3583
50	L	H	0.0000
51	E	H	-0.8765
52	W	H	0.0000
53	V	H	0.0000
54	G	H	0.0000
55	R	H	0.0000
56	I	H	0.0000
57	R	H	-0.9714
58	S	H	0.0000
59	K	H	-2.6406
60	S	H	-1.8151
61	N	H	-1.8940
62	N	H	-2.1456
63	Y	H	-1.1709
64	A	H	-0.6628
65	T	H	0.1351
66	Y	H	0.3973
67	Y	H	-0.4875
68	A	H	0.0000
69	D	H	-2.4427
70	S	H	-1.8146
71	V	H	0.0000
72	K	H	-2.6278
74	D	H	-2.7980
75	R	H	-1.9364
76	F	H	0.0000
77	T	H	-0.8884
78	I	H	0.0000
79	S	H	-0.2623
80	R	H	-1.0769
81	D	H	-1.6307
82	D	H	-1.8372
83	S	H	-1.5705
84	K	H	-2.4041
85	N	H	-1.8680
86	T	H	-1.0047
87	A	H	0.0000
88	Y	H	-0.4392
89	L	H	0.0000
90	Q	H	-1.0396
91	M	H	0.0000
92	N	H	-1.4763
93	S	H	-1.3512
94	L	H	0.0000
95	K	H	-2.2856
96	T	H	-1.8099
97	E	H	-2.3031
98	D	H	0.0000
99	T	H	-0.6462
100	A	H	0.0000
101	V	H	0.1182
102	Y	H	0.0000
103	Y	H	0.0000
104	C	H	0.0000
105	V	H	0.0000
106	R	H	0.0388
107	G	H	0.0000
108	L	H	0.1312
109	L	H	-0.0495
110	R	H	-1.2011
112	Y	H	-0.1405
113	R	H	-0.1619
114	F	H	0.0530
115	F	H	0.0000
116	D	H	-0.3581
117	V	H	-0.0235
118	W	H	-0.0871
119	G	H	0.0000
120	Q	H	-1.0843
121	G	H	-0.4405
122	T	H	0.0000
123	T	H	0.0889
124	V	H	0.0000
125	T	H	-0.0305
126	V	H	0.0000
127	S	H	-0.7283
128	S	H	-0.5615
1	D	L	-1.7137
2	I	L	0.0000
3	V	L	0.6328
4	M	L	0.0000
5	T	L	-0.3852
6	Q	L	0.0000
7	S	L	-0.1384
8	P	L	0.2742
9	L	L	1.0757
10	S	L	0.1583
11	L	L	0.0040
12	P	L	-0.5745
13	V	L	0.0000
14	T	L	-1.3275
15	P	L	-1.4198
16	G	L	-1.8308
17	E	L	-2.1743
18	P	L	-1.8427
19	A	L	0.0000
20	S	L	-0.7508
21	I	L	0.0000
22	S	L	-0.8102
23	C	L	0.0000
24	R	L	-2.3651
25	S	L	0.0000
26	S	L	-1.2298
27	K	L	-1.9503
28	S	L	-1.0048
29	L	L	0.0000
30	L	L	0.5460
31	H	L	-0.3889
32	S	L	-0.8645
34	N	L	-1.5848
35	G	L	-1.0715
36	N	L	-0.7140
37	T	L	0.0000
38	Y	L	0.0000
39	L	L	0.0000
40	Y	L	0.0000
41	W	L	0.0000
42	F	L	0.0000
43	L	L	0.0000
44	Q	L	-0.7723
45	K	L	-1.2011
46	P	L	-0.8372
47	G	L	-1.3344
48	Q	L	-1.8536
49	S	L	-1.2355
50	P	L	0.0000
51	Q	L	-0.7941
52	L	L	0.0000
53	L	L	0.0000
54	I	L	0.0000
55	Y	L	0.0433
56	R	L	-0.1526
57	M	L	-0.1256
65	S	L	-0.4214
66	N	L	-0.4349
67	L	L	-0.1715
68	A	L	-0.1281
69	S	L	-0.3834
70	G	L	-0.6308
71	V	L	-0.5066
72	P	L	-0.9370
74	D	L	-1.8107
75	R	L	0.0000
76	F	L	0.0000
77	S	L	-0.9770
78	G	L	-0.5555
79	S	L	-0.6970
80	G	L	-0.9119
83	S	L	-0.6765
84	G	L	-0.7314
85	T	L	-1.5408
86	D	L	-2.0786
87	F	L	0.0000
88	T	L	-0.9624
89	L	L	0.0000
90	K	L	-1.4931
91	I	L	0.0000
92	S	L	-1.9987
93	R	L	-2.6407
94	V	L	0.0000
95	E	L	-1.6416
96	A	L	-1.0461
97	E	L	-1.7892
98	D	L	0.0000
99	V	L	-0.3348
100	G	L	-0.6912
101	V	L	-0.0486
102	Y	L	0.0000
103	Y	L	0.0000
104	C	L	0.0000
105	M	L	0.0000
106	Q	L	0.0000
107	H	L	0.0000
108	L	L	-0.5508
109	E	L	-1.5701
114	Y	L	-0.2735
115	P	L	-0.6533
116	F	L	0.0000
117	T	L	-0.1336
118	F	L	0.1875
119	G	L	0.0000
120	G	L	-0.4003
121	G	L	0.0000
122	T	L	0.0000
123	K	L	-0.6448
124	V	L	0.0000
125	E	L	-0.4332
126	I	L	-0.0820
127	K	L	-1.4896