| Chain sequence(s) |
A: GPLPLNPEPAPLPTSDYVTPTDLYYIAETDLLTETGDPTKDVVVDGKVEKPRVSAWQYRVFLLTLPDPNKLPLPSEDALDPATERRIWRLLAYKIHVYGPLGVGEVGHPTFNKFGDVTNPTEYQHEGADDTVAYSFTPKLLQSYIIGDRPPTAKYTAPAAPAPGLPPGAIPPTETKTTIIQDGDMADIGFGAKDYAALEPSKDDVPDIIRDTVTKVFDIEGMKAEPWGDRLFDYDRYEKSKDVEKYVRDGPDLIPLPDAPAPSPLYVEPPPTSPYYVRPSTDYFTIPDRGEITEDDLLFNKPVFLEKTPGLNDGVLWHNRLYITVVDNTRAEVKTIKTQTCTPEPNVYDPSCYTTSKEYTREYQISLIIQLCTVPLTPETLALLERRDPRILVNWELPFVPPVERPDPLAGLKFREIDLTDKLSSDLEKYELGRLFLNR
input PDB |
| Selected Chain(s) | A |
| Distance of aggregation | 10 Å |
| FoldX usage | No |
| Dynamic mode | No |
| Automated mutations | No |
| Downloads | Download all the data |
| Simulation log |
[INFO] Logger: Verbosity set to: 2 - [INFO] (00:00:00)
[WARNING] runJob: Working directory already exists (possibly overwriting previous results -ow
to prevent this behavior) (00:00:00)
[INFO] runJob: Starting aggrescan3d job on: input.pdb with A chain(s) selected (00:00:00)
[INFO] runJob: Creating pdb object from: input.pdb (00:00:00)
[INFO] runJob: FoldX not utilized. Treating input pdb file as it was already optimized. (00:00:00)
[INFO] Analysis: Starting Aggrescan3D on folded.pdb (00:00:01)
[INFO] Main: Simulation completed successfully. (00:00:05)
|
The table below lists A3D score for protein residues. Residues with A3D score > 0.0000 are marked by yellow rows.
| residue index | residue name | chain | Aggrescan3D score | mutation |
|---|---|---|---|---|
| residue index | residue name | chain | Aggrescan3D score | |
| 1 | G | A | -0.2105 | |
| 2 | P | A | 0.4214 | |
| 3 | L | A | 1.3936 | |
| 4 | P | A | 0.7033 | |
| 5 | L | A | 0.8463 | |
| 6 | N | A | -1.0221 | |
| 7 | P | A | -1.4319 | |
| 8 | E | A | -2.2266 | |
| 9 | P | A | -1.2201 | |
| 10 | A | A | -0.3737 | |
| 11 | P | A | 0.1158 | |
| 12 | L | A | 0.6242 | |
| 13 | P | A | -0.1121 | |
| 14 | T | A | 0.0000 | |
| 15 | S | A | -1.0139 | |
| 16 | D | A | -1.6437 | |
| 17 | Y | A | 0.0000 | |
| 18 | V | A | 0.0000 | |
| 19 | T | A | -0.5178 | |
| 20 | P | A | -0.6011 | |
| 21 | T | A | -0.9390 | |
| 22 | D | A | -1.6895 | |
| 23 | L | A | -0.5009 | |
| 24 | Y | A | 0.0457 | |
| 25 | Y | A | 0.2370 | |
| 26 | I | A | 0.0000 | |
| 27 | A | A | 0.0000 | |
| 28 | E | A | -0.8768 | |
| 29 | T | A | 0.0000 | |
| 30 | D | A | -1.3920 | |
| 31 | L | A | 0.1303 | |
| 32 | L | A | -0.0758 | |
| 33 | T | A | -0.2256 | |
| 34 | E | A | -0.4033 | |
| 35 | T | A | -0.5225 | |
| 36 | G | A | 0.0000 | |
| 37 | D | A | -1.9626 | |
| 38 | P | A | 0.0000 | |
| 39 | T | A | -1.5586 | |
| 40 | K | A | -2.1158 | |
| 41 | D | A | -1.6110 | |
| 42 | V | A | 0.0225 | |
| 43 | V | A | 0.9738 | |
| 44 | V | A | 0.4369 | |
| 45 | D | A | -1.4941 | |
| 46 | G | A | -1.0370 | |
| 47 | K | A | -1.2918 | |
| 48 | V | A | 0.1344 | |
| 49 | E | A | -1.1931 | |
| 50 | K | A | -1.0063 | |
| 51 | P | A | -1.1457 | |
| 52 | R | A | -1.6184 | |
| 53 | V | A | 0.0000 | |
| 54 | S | A | 0.0000 | |
| 55 | A | A | 0.0000 | |
| 56 | W | A | 0.0000 | |
| 57 | Q | A | 0.0000 | |
| 58 | Y | A | 0.0000 | |
| 59 | R | A | 0.0000 | |
| 60 | V | A | 0.0000 | |
| 61 | F | A | 0.0000 | |
| 62 | L | A | 0.0000 | |
| 63 | L | A | 0.0000 | |
| 64 | T | A | -1.4371 | |
| 65 | L | A | 0.0000 | |
| 66 | P | A | -1.3271 | |
| 67 | D | A | -1.3410 | |
| 68 | P | A | 0.0000 | |
| 69 | N | A | -1.4246 | |
| 70 | K | A | -1.9788 | |
| 71 | L | A | -0.8914 | |
| 72 | P | A | -0.6895 | |
| 73 | L | A | -0.7711 | |
| 74 | P | A | -1.1447 | |
| 75 | S | A | -1.4643 | |
| 76 | E | A | -2.4182 | |
| 77 | D | A | -2.2718 | |
| 78 | A | A | -1.3881 | |
| 79 | L | A | -1.2633 | |
| 80 | D | A | -1.8127 | |
| 81 | P | A | -1.1189 | |
| 82 | A | A | -0.7188 | |
| 83 | T | A | -0.7358 | |
| 84 | E | A | -0.9094 | |
| 85 | R | A | 0.0000 | |
| 86 | R | A | 0.0000 | |
| 87 | I | A | 0.0000 | |
| 88 | W | A | 0.0000 | |
| 89 | R | A | -0.3192 | |
| 90 | L | A | 0.0000 | |
| 91 | L | A | -0.1738 | |
| 92 | A | A | 0.0000 | |
| 93 | Y | A | 0.0000 | |
| 94 | K | A | -0.9498 | |
| 95 | I | A | 0.0000 | |
| 96 | H | A | -0.6256 | |
| 97 | V | A | 0.0000 | |
| 98 | Y | A | 0.1381 | |
| 99 | G | A | -0.4357 | |
| 100 | P | A | -0.1305 | |
| 101 | L | A | 0.3293 | |
| 102 | G | A | 0.2437 | |
| 103 | V | A | 0.2977 | |
| 104 | G | A | 0.0000 | |
| 105 | E | A | -1.8975 | |
| 106 | V | A | 0.0000 | |
| 107 | G | A | -0.8037 | |
| 108 | H | A | 0.0000 | |
| 109 | P | A | -0.1877 | |
| 110 | T | A | -0.5488 | |
| 111 | F | A | 0.0000 | |
| 112 | N | A | 0.0000 | |
| 113 | K | A | -0.5997 | |
| 114 | F | A | 0.0000 | |
| 115 | G | A | 0.0000 | |
| 116 | D | A | -1.8213 | |
| 117 | V | A | -0.9382 | |
| 118 | T | A | -1.4227 | |
| 119 | N | A | -2.0889 | |
| 120 | P | A | -1.5013 | |
| 121 | T | A | -1.4182 | |
| 122 | E | A | -2.0917 | |
| 123 | Y | A | -0.5722 | |
| 124 | Q | A | -1.2202 | |
| 125 | H | A | -1.2859 | |
| 126 | E | A | -2.1421 | |
| 127 | G | A | -1.7906 | |
| 128 | A | A | -1.6777 | |
| 129 | D | A | -2.3647 | |
| 130 | D | A | -1.7841 | |
| 131 | T | A | -0.7808 | |
| 132 | V | A | 0.2696 | |
| 133 | A | A | 0.2919 | |
| 134 | Y | A | 0.1620 | |
| 135 | S | A | -0.6299 | |
| 136 | F | A | 0.0000 | |
| 137 | T | A | -0.7956 | |
| 138 | P | A | 0.0000 | |
| 139 | K | A | 0.0000 | |
| 140 | L | A | 0.0000 | |
| 141 | L | A | 0.0000 | |
| 142 | Q | A | 0.0000 | |
| 143 | S | A | 0.0000 | |
| 144 | Y | A | 0.0000 | |
| 145 | I | A | 0.0000 | |
| 146 | I | A | 0.0000 | |
| 147 | G | A | 0.0000 | |
| 148 | D | A | 0.0000 | |
| 149 | R | A | -0.6008 | |
| 150 | P | A | 0.0000 | |
| 151 | P | A | 0.0000 | |
| 152 | T | A | -0.4230 | |
| 153 | A | A | 0.0000 | |
| 154 | K | A | -1.1464 | |
| 155 | Y | A | -0.9170 | |
| 156 | T | A | -0.9054 | |
| 157 | A | A | 0.0000 | |
| 158 | P | A | -0.4051 | |
| 159 | A | A | -0.6246 | |
| 160 | A | A | -0.2992 | |
| 161 | P | A | -0.1030 | |
| 162 | A | A | -0.2001 | |
| 163 | P | A | -0.3913 | |
| 164 | G | A | -0.4421 | |
| 165 | L | A | 0.2159 | |
| 166 | P | A | -0.1500 | |
| 167 | P | A | -0.2769 | |
| 168 | G | A | 0.1517 | |
| 169 | A | A | 0.8974 | |
| 170 | I | A | 2.0432 | |
| 171 | P | A | 0.5877 | |
| 172 | P | A | 0.0467 | |
| 173 | T | A | -0.5835 | |
| 174 | E | A | -1.4388 | |
| 175 | T | A | -1.2519 | |
| 176 | K | A | -1.4593 | |
| 177 | T | A | -0.8843 | |
| 178 | T | A | -0.3421 | |
| 179 | I | A | -0.1016 | |
| 180 | I | A | 0.0000 | |
| 181 | Q | A | -0.8612 | |
| 182 | D | A | -1.0911 | |
| 183 | G | A | -0.7369 | |
| 184 | D | A | -0.5639 | |
| 185 | M | A | 0.0000 | |
| 186 | A | A | 0.0000 | |
| 187 | D | A | -0.1809 | |
| 188 | I | A | 0.0000 | |
| 189 | G | A | -0.4766 | |
| 190 | F | A | -0.0270 | |
| 191 | G | A | -0.2713 | |
| 192 | A | A | -0.3466 | |
| 193 | K | A | -0.6515 | |
| 194 | D | A | -0.6097 | |
| 195 | Y | A | 0.0000 | |
| 196 | A | A | -1.0724 | |
| 197 | A | A | -0.4734 | |
| 198 | L | A | -0.1941 | |
| 199 | E | A | -1.1278 | |
| 200 | P | A | -1.1637 | |
| 201 | S | A | -1.2644 | |
| 202 | K | A | -2.3814 | |
| 203 | D | A | -1.4524 | |
| 204 | D | A | -1.1948 | |
| 205 | V | A | 0.0000 | |
| 206 | P | A | 0.0000 | |
| 207 | D | A | -1.7062 | |
| 208 | I | A | 0.0000 | |
| 209 | I | A | 0.0000 | |
| 210 | R | A | -1.9975 | |
| 211 | D | A | -2.1378 | |
| 212 | T | A | -0.9379 | |
| 213 | V | A | -0.2110 | |
| 214 | T | A | 0.0000 | |
| 215 | K | A | 0.0000 | |
| 216 | V | A | -0.1760 | |
| 217 | F | A | 0.0000 | |
| 218 | D | A | -1.1936 | |
| 219 | I | A | -1.1915 | |
| 220 | E | A | -2.3753 | |
| 221 | G | A | -1.7361 | |
| 222 | M | A | 0.0000 | |
| 223 | K | A | -2.2590 | |
| 224 | A | A | -1.4210 | |
| 225 | E | A | -1.2530 | |
| 226 | P | A | -0.4610 | |
| 227 | W | A | -0.1603 | |
| 228 | G | A | 0.0000 | |
| 229 | D | A | 0.0000 | |
| 230 | R | A | -0.6805 | |
| 231 | L | A | 0.0000 | |
| 232 | F | A | 0.0000 | |
| 233 | D | A | -0.4323 | |
| 234 | Y | A | -0.2198 | |
| 235 | D | A | -0.9857 | |
| 236 | R | A | -1.2029 | |
| 237 | Y | A | -0.7324 | |
| 238 | E | A | -1.1356 | |
| 239 | K | A | -1.7971 | |
| 240 | S | A | -2.2983 | |
| 241 | K | A | -3.3212 | |
| 242 | D | A | -3.0842 | |
| 243 | V | A | -2.1209 | |
| 244 | E | A | -2.9189 | |
| 245 | K | A | -2.1578 | |
| 246 | Y | A | 0.0000 | |
| 247 | V | A | 0.0000 | |
| 248 | R | A | 0.0000 | |
| 249 | D | A | -1.8047 | |
| 250 | G | A | -1.1662 | |
| 251 | P | A | -0.4771 | |
| 252 | D | A | 0.4351 | |
| 253 | L | A | 2.3141 | |
| 254 | I | A | 2.5693 | |
| 255 | P | A | 0.8386 | |
| 256 | L | A | 0.6868 | |
| 257 | P | A | -0.3324 | |
| 258 | D | A | -1.9154 | |
| 259 | A | A | -0.7459 | |
| 260 | P | A | -1.0007 | |
| 261 | A | A | -0.4558 | |
| 262 | P | A | 0.0068 | |
| 263 | S | A | 0.1062 | |
| 264 | P | A | 0.7170 | |
| 265 | L | A | 1.5184 | |
| 266 | Y | A | 1.1498 | |
| 267 | V | A | 1.1885 | |
| 268 | E | A | -0.7746 | |
| 269 | P | A | -0.0333 | |
| 270 | P | A | -0.3294 | |
| 271 | P | A | -0.1307 | |
| 272 | T | A | 0.1069 | |
| 273 | S | A | 0.3114 | |
| 274 | P | A | 0.6062 | |
| 275 | Y | A | 1.3192 | |
| 276 | Y | A | 1.0589 | |
| 277 | V | A | 1.1022 | |
| 278 | R | A | 0.0157 | |
| 279 | P | A | -0.6202 | |
| 280 | S | A | 0.0000 | |
| 281 | T | A | -0.4663 | |
| 282 | D | A | -1.1091 | |
| 283 | Y | A | 0.1877 | |
| 284 | F | A | -0.0942 | |
| 285 | T | A | -0.7501 | |
| 286 | I | A | 0.0000 | |
| 287 | P | A | 0.0000 | |
| 288 | D | A | -2.4830 | |
| 289 | R | A | 0.0000 | |
| 290 | G | A | -2.0090 | |
| 291 | E | A | -2.0239 | |
| 292 | I | A | -1.1597 | |
| 293 | T | A | -1.7973 | |
| 294 | E | A | -2.5852 | |
| 295 | D | A | -2.7250 | |
| 296 | D | A | -1.9066 | |
| 297 | L | A | -1.0807 | |
| 298 | L | A | -0.9153 | |
| 299 | F | A | 0.0000 | |
| 300 | N | A | -1.1819 | |
| 301 | K | A | -1.7607 | |
| 302 | P | A | -0.8657 | |
| 303 | V | A | -0.1495 | |
| 304 | F | A | -0.3583 | |
| 305 | L | A | -1.0128 | |
| 306 | E | A | -2.4581 | |
| 307 | K | A | -2.6685 | |
| 308 | T | A | 0.0000 | |
| 309 | P | A | -0.9932 | |
| 310 | G | A | -0.9040 | |
| 311 | L | A | -0.2496 | |
| 312 | N | A | 0.0000 | |
| 313 | D | A | -1.2043 | |
| 314 | G | A | 0.0000 | |
| 315 | V | A | 0.0000 | |
| 316 | L | A | 0.0000 | |
| 317 | W | A | 0.0000 | |
| 318 | H | A | -0.8574 | |
| 319 | N | A | -0.8971 | |
| 320 | R | A | -1.3355 | |
| 321 | L | A | 0.0000 | |
| 322 | Y | A | 0.0000 | |
| 323 | I | A | 0.0000 | |
| 324 | T | A | 0.0000 | |
| 325 | V | A | 0.0000 | |
| 326 | V | A | 0.0000 | |
| 327 | D | A | 0.0000 | |
| 328 | N | A | 0.0000 | |
| 329 | T | A | 0.0000 | |
| 330 | R | A | -0.1967 | |
| 331 | A | A | 0.0000 | |
| 332 | E | A | -1.9310 | |
| 333 | V | A | -1.8096 | |
| 334 | K | A | -2.4337 | |
| 335 | T | A | -1.4386 | |
| 336 | I | A | -0.4101 | |
| 337 | K | A | -1.7031 | |
| 338 | T | A | -1.0199 | |
| 339 | Q | A | -1.4234 | |
| 340 | T | A | -0.5606 | |
| 341 | C | A | -0.2387 | |
| 342 | T | A | -0.6025 | |
| 343 | P | A | -0.7323 | |
| 344 | E | A | -1.5429 | |
| 345 | P | A | -1.0268 | |
| 346 | N | A | -0.7723 | |
| 347 | V | A | 0.9112 | |
| 348 | Y | A | 1.1447 | |
| 349 | D | A | -0.1385 | |
| 350 | P | A | -0.1390 | |
| 351 | S | A | -0.3351 | |
| 352 | C | A | 0.0000 | |
| 353 | Y | A | -0.4862 | |
| 354 | T | A | -0.5895 | |
| 355 | T | A | -0.8223 | |
| 356 | S | A | -1.2092 | |
| 357 | K | A | -2.0425 | |
| 358 | E | A | -1.7507 | |
| 359 | Y | A | 0.0000 | |
| 360 | T | A | -0.8425 | |
| 361 | R | A | 0.0000 | |
| 362 | E | A | -0.2627 | |
| 363 | Y | A | 0.0000 | |
| 364 | Q | A | -0.5107 | |
| 365 | I | A | 0.0000 | |
| 366 | S | A | 0.0000 | |
| 367 | L | A | 0.0000 | |
| 368 | I | A | 0.0000 | |
| 369 | I | A | 0.0000 | |
| 370 | Q | A | 0.0000 | |
| 371 | L | A | 0.0000 | |
| 372 | C | A | 0.0000 | |
| 373 | T | A | -0.2358 | |
| 374 | V | A | 0.0000 | |
| 375 | P | A | -0.5977 | |
| 376 | L | A | -0.3382 | |
| 377 | T | A | -0.7017 | |
| 378 | P | A | -1.0352 | |
| 379 | E | A | -1.9550 | |
| 380 | T | A | 0.0000 | |
| 381 | L | A | -0.7766 | |
| 382 | A | A | -1.0497 | |
| 383 | L | A | 0.0000 | |
| 384 | L | A | 0.0000 | |
| 385 | E | A | -1.5230 | |
| 386 | R | A | -1.3274 | |
| 387 | R | A | 0.0000 | |
| 388 | D | A | 0.0000 | |
| 389 | P | A | -1.0148 | |
| 390 | R | A | -1.3867 | |
| 391 | I | A | 0.0000 | |
| 392 | L | A | 0.0000 | |
| 393 | V | A | -1.0439 | |
| 394 | N | A | -1.9151 | |
| 395 | W | A | -1.4242 | |
| 396 | E | A | -1.8621 | |
| 397 | L | A | 0.0000 | |
| 398 | P | A | 0.2995 | |
| 399 | F | A | 1.6333 | |
| 400 | V | A | 0.8184 | |
| 401 | P | A | 0.3212 | |
| 402 | P | A | -0.2963 | |
| 403 | V | A | 0.3272 | |
| 404 | E | A | -2.0695 | |
| 405 | R | A | -2.3424 | |
| 406 | P | A | -1.6884 | |
| 407 | D | A | -1.6244 | |
| 408 | P | A | -0.8031 | |
| 409 | L | A | -0.4012 | |
| 410 | A | A | -0.5652 | |
| 411 | G | A | -0.6907 | |
| 412 | L | A | -0.5751 | |
| 413 | K | A | -1.9369 | |
| 414 | F | A | -1.3972 | |
| 415 | R | A | -1.7691 | |
| 416 | E | A | -2.6726 | |
| 417 | I | A | 0.0000 | |
| 418 | D | A | -2.7453 | |
| 419 | L | A | 0.0000 | |
| 420 | T | A | -1.6125 | |
| 421 | D | A | -2.2692 | |
| 422 | K | A | -1.8211 | |
| 423 | L | A | -0.6498 | |
| 424 | S | A | -0.7350 | |
| 425 | S | A | -0.7357 | |
| 426 | D | A | -1.8805 | |
| 427 | L | A | 0.0000 | |
| 428 | E | A | -3.6158 | |
| 429 | K | A | -3.4314 | |
| 430 | Y | A | -2.5568 | |
| 431 | E | A | -2.8478 | |
| 432 | L | A | 0.0000 | |
| 433 | G | A | 0.0000 | |
| 434 | R | A | -3.2368 | |
| 435 | L | A | -1.3221 | |
| 436 | F | A | -0.7525 | |
| 437 | L | A | -0.6295 | |
| 438 | N | A | -1.9681 | |
| 439 | R | A | -2.0411 |
ALA alanine
ARG arginine
ASN asparagine
ASP aspartic acid
CYS cysteine
GLN glutamine
GLU glutamic acid
GLY glycine
HIS histidine
ILE isoleucine
LEU leucine
LYS lysine
MET methionine
PHE phenylalanine
PRO proline
SER serine
THR threonine
TRP tryptophan
TYR tyrosine
VAL valine