Project name: fec0cc5b913db8a

Chain sequence(s)	H: EVQLVESGGGLVQPGGSLRLSCAASGFTFNNYAMNWVRQAPGKGLDWVSTISGSGGTTNYADSVKGRFIISRDSSKHTLYLQMNSLRAEDTAVYYCAKDSNWGNFDLWGRGTLVTVSS; L: DIVMTQSPDSLAVSLGERATINCKSSQSVLYRSNNRNFLGWYQQKPGQPPNLLIYWASTRESGVPDRFSGSGSGTDFTLTISSLQAEDVAVYYCQQYYTTPYTFGQGTKLEIK
Selected Chain(s)	H,L
Distance of aggregation	10 Å
FoldX usage	Yes
Dynamic mode	No
Automated mutations	No

Simulation log

[INFO]       Logger:   Verbosity set to: 2 - [INFO]                                                (00:00:01)
[WARNING]    runJob:   Working directory already exists (possibly overwriting previous results -ow 
                       to prevent this behavior)                                                   (00:00:01)
[INFO]       runJob:   Starting aggrescan3d job on: input.pdb with all chain(s) selected           (00:00:01)
[INFO]       runJob:   Creating pdb object from: input.pdb                                         (00:00:01)
[INFO]       FoldX:    Starting FoldX energy minimalization                                        (00:00:01)
[INFO]       Analysis: Starting Aggrescan3D on folded.pdb                                          (00:01:33)
[INFO]       Main:     Simulation completed successfully.                                          (00:01:34)

• Minimal score value: -2.8245
• Maximal score value: 1.5083
• Average score: -0.6622
• Total score value: -152.9748

The table below lists A3D score for protein residues. Residues with A3D score > 0.0000 are marked by yellow rows.

residue index	residue name	chain	Aggrescan3D score	mutation
1	E	H	-1.5663
2	V	H	-0.1695
3	Q	H	-0.6680
4	L	H	0.0000
5	V	H	0.3541
6	E	H	0.0000
7	S	H	-0.2873
8	G	H	-0.4191
9	G	H	0.2490
11	G	H	0.8486
12	L	H	1.3583
13	V	H	-0.0536
14	Q	H	-1.3609
15	P	H	-1.6561
16	G	H	-1.4150
17	G	H	-0.9707
18	S	H	-1.0302
19	L	H	-0.6370
20	R	H	-1.2585
21	L	H	0.0000
22	S	H	-0.2761
23	C	H	0.0000
24	A	H	-0.3094
25	A	H	0.0000
26	S	H	-0.7520
27	G	H	-0.6957
28	F	H	-0.4446
29	T	H	-0.7463
30	F	H	0.0000
35	N	H	-1.6970
36	N	H	-1.7185
37	Y	H	-0.8675
38	A	H	-0.5715
39	M	H	0.0000
40	N	H	0.0000
41	W	H	0.0000
42	V	H	0.0000
43	R	H	0.0000
44	Q	H	-0.6681
45	A	H	-1.0441
46	P	H	-0.8298
47	G	H	-1.4554
48	K	H	-2.3330
49	G	H	-1.5216
50	L	H	0.0000
51	D	H	-1.0863
52	W	H	0.0000
53	V	H	0.0000
54	S	H	0.0000
55	T	H	-0.1936
56	I	H	0.0000
57	S	H	-0.8120
58	G	H	-1.1349
59	S	H	-0.9428
62	G	H	-0.7545
63	G	H	-0.6697
64	T	H	-0.5249
65	T	H	-0.1972
66	N	H	-0.6908
67	Y	H	-0.9466
68	A	H	-1.5664
69	D	H	-2.5679
70	S	H	-1.8010
71	V	H	0.0000
72	K	H	-2.4700
74	G	H	-1.4337
75	R	H	-1.0894
76	F	H	0.0000
77	I	H	0.5380
78	I	H	0.0000
79	S	H	-0.0964
80	R	H	-0.9983
81	D	H	-1.4291
82	S	H	-1.5574
83	S	H	-1.5174
84	K	H	-2.3354
85	H	H	-1.9195
86	T	H	-1.1205
87	L	H	0.0000
88	Y	H	-0.1746
89	L	H	0.0000
90	Q	H	-0.4935
91	M	H	0.0000
92	N	H	-0.9190
93	S	H	-1.1790
94	L	H	0.0000
95	R	H	-2.3071
96	A	H	-1.7185
97	E	H	-2.2543
98	D	H	0.0000
99	T	H	-0.3596
100	A	H	0.0000
101	V	H	0.7088
102	Y	H	0.0000
103	Y	H	0.0000
104	C	H	0.0000
105	A	H	0.0000
106	K	H	0.0000
107	D	H	0.0000
108	S	H	-0.6374
109	N	H	-1.2591
110	W	H	-0.0523
113	G	H	0.0000
114	N	H	0.0000
115	F	H	0.0000
116	D	H	-1.2001
117	L	H	-0.4071
118	W	H	0.0000
119	G	H	0.0000
120	R	H	-1.7726
121	G	H	-0.5303
122	T	H	0.0000
123	L	H	1.5083
124	V	H	0.0000
125	T	H	0.3299
126	V	H	0.0000
127	S	H	-0.7263
128	S	H	-0.5019
1	D	L	-1.5672
2	I	L	0.0000
3	V	L	0.7310
4	M	L	0.0000
5	T	L	-0.7680
6	Q	L	0.0000
7	S	L	-1.2676
8	P	L	-1.2627
9	D	L	-2.2817
10	S	L	-1.4697
11	L	L	-0.8214
12	A	L	-0.5148
13	V	L	-1.1266
14	S	L	-1.2380
15	L	L	-0.4254
16	G	L	-1.1853
17	E	L	-2.7822
18	R	L	-2.8034
19	A	L	0.0000
20	T	L	-0.6010
21	I	L	0.0000
22	N	L	-1.3470
23	C	L	0.0000
24	K	L	-2.0473
25	S	L	0.0000
26	S	L	-0.9058
27	Q	L	-1.4899
28	S	L	-0.9345
29	V	L	0.0000
30	L	L	-0.8720
31	Y	L	-0.8636
32	R	L	-2.4881
33	S	L	-1.9239
34	N	L	-2.5963
35	N	L	-2.8245
36	R	L	-2.1553
37	N	L	0.0000
38	F	L	0.2593
39	L	L	0.0000
40	G	L	0.0000
41	W	L	0.0000
42	Y	L	0.0000
43	Q	L	0.0000
44	Q	L	0.0000
45	K	L	-1.1762
46	P	L	-0.7826
47	G	L	-1.3549
48	Q	L	-1.9141
49	P	L	-1.4820
50	P	L	0.0000
51	N	L	-1.5358
52	L	L	0.0000
53	L	L	0.0000
54	I	L	0.0000
55	Y	L	-0.3099
56	W	L	0.0000
57	A	L	0.0000
65	S	L	-0.7304
66	T	L	-0.6378
67	R	L	-1.4998
68	E	L	-1.3043
69	S	L	-0.8069
70	G	L	-0.9578
71	V	L	-1.0749
72	P	L	-1.3089
74	D	L	-2.2439
75	R	L	-1.5424
76	F	L	0.0000
77	S	L	-0.9320
78	G	L	0.0000
79	S	L	-0.7032
80	G	L	-1.0812
83	S	L	-1.2093
84	G	L	-1.2184
85	T	L	-1.5323
86	D	L	-2.2333
87	F	L	0.0000
88	T	L	-0.8859
89	L	L	0.0000
90	T	L	-0.6777
91	I	L	0.0000
92	S	L	-1.8735
93	S	L	-1.7957
94	L	L	0.0000
95	Q	L	-0.8662
96	A	L	-0.7802
97	E	L	-1.6021
98	D	L	0.0000
99	V	L	-0.1930
100	A	L	0.0000
101	V	L	-0.4545
102	Y	L	0.0000
103	Y	L	0.0000
104	C	L	0.0000
105	Q	L	0.0000
106	Q	L	0.0000
107	Y	L	0.0000
108	Y	L	0.6160
109	T	L	-0.0334
114	T	L	-0.3575
115	P	L	-0.8191
116	Y	L	0.0000
117	T	L	-0.1088
118	F	L	0.0000
119	G	L	0.0000
120	Q	L	-1.4071
121	G	L	0.0000
122	T	L	0.0000
123	K	L	-1.3668
124	L	L	0.0000
125	E	L	-1.0202
126	I	L	-0.7562
127	K	L	-1.5715