| Chain sequence(s) |
A: GLPPGAPEPPLRPTSAYVTPTDLLYVAETDLITRTGNPTKDVVVDGKVLVPKVSAYQWRVFLLTLPDPNTMPLPSSDFLDPATEIRIWQLKAIKIHRFGPLGTGTYGHANFNRFGDVDNPTEYQHEGADDRVNYSFTPKKLQSYIIGDEPPIGKYTAKAEPKPGLPPGAIPPTKTVTTIIEDGDMADIGFGAKNFKELEPSKDEVPDDILNTTTKVIDYEGMKAEPYGRRMFTHDSYEKSKDVKKLRRSGPDLIPLPDAPPPSRLYVRPPPWSPYAVRPSTDYFTIPDRGEINESDLLFNKPYFLEKTPGKNQGVLWGNRLYITILDNTRDEIATHTTQISTPAENVYDPSNYVTSKTYTEQYKISLIVQLCTIPLTPETLAELARLDPSFLVRAQLPFVPPVETADPYAGKTFLKLDLTDKLSSNLSLTELGREYLNK
input PDB |
| Selected Chain(s) | A |
| Distance of aggregation | 10 Å |
| FoldX usage | No |
| Dynamic mode | No |
| Automated mutations | No |
| Downloads | Download all the data |
| Simulation log |
[INFO] Logger: Verbosity set to: 2 - [INFO] (00:00:09)
[WARNING] runJob: Working directory already exists (possibly overwriting previous results -ow
to prevent this behavior) (00:00:09)
[INFO] runJob: Starting aggrescan3d job on: input.pdb with A chain(s) selected (00:00:09)
[INFO] runJob: Creating pdb object from: input.pdb (00:00:09)
[INFO] runJob: FoldX not utilized. Treating input pdb file as it was already optimized. (00:00:09)
[INFO] Analysis: Starting Aggrescan3D on folded.pdb (00:00:10)
[INFO] Main: Simulation completed successfully. (00:00:14)
|
The table below lists A3D score for protein residues. Residues with A3D score > 0.0000 are marked by yellow rows.
| residue index | residue name | chain | Aggrescan3D score | mutation |
|---|---|---|---|---|
| residue index | residue name | chain | Aggrescan3D score | |
| 1 | G | A | 0.1526 | |
| 2 | L | A | 1.0651 | |
| 3 | P | A | 0.1334 | |
| 4 | P | A | -0.2972 | |
| 5 | G | A | -0.7043 | |
| 6 | A | A | -0.8796 | |
| 7 | P | A | -1.3646 | |
| 8 | E | A | -2.1541 | |
| 9 | P | A | -1.3671 | |
| 10 | P | A | -1.0141 | |
| 11 | L | A | -0.8550 | |
| 12 | R | A | -0.9989 | |
| 13 | P | A | -0.7964 | |
| 14 | T | A | 0.0000 | |
| 15 | S | A | -0.6865 | |
| 16 | A | A | -0.3352 | |
| 17 | Y | A | 0.0000 | |
| 18 | V | A | 0.0000 | |
| 19 | T | A | -0.2804 | |
| 20 | P | A | -0.7314 | |
| 21 | T | A | -0.8017 | |
| 22 | D | A | -1.6830 | |
| 23 | L | A | -0.5991 | |
| 24 | L | A | -0.3178 | |
| 25 | Y | A | -0.2339 | |
| 26 | V | A | 0.0000 | |
| 27 | A | A | 0.0000 | |
| 28 | E | A | -0.7268 | |
| 29 | T | A | 0.0000 | |
| 30 | D | A | -1.2392 | |
| 31 | L | A | 0.5239 | |
| 32 | I | A | 0.3056 | |
| 33 | T | A | -0.0384 | |
| 34 | R | A | -0.4685 | |
| 35 | T | A | -0.2988 | |
| 36 | G | A | 0.0000 | |
| 37 | N | A | -1.1356 | |
| 38 | P | A | 0.0000 | |
| 39 | T | A | -1.4990 | |
| 40 | K | A | -1.9490 | |
| 41 | D | A | -0.6071 | |
| 42 | V | A | 1.4780 | |
| 43 | V | A | 2.3164 | |
| 44 | V | A | 1.5710 | |
| 45 | D | A | -0.9987 | |
| 46 | G | A | -0.5687 | |
| 47 | K | A | -0.1893 | |
| 48 | V | A | 2.0522 | |
| 49 | L | A | 2.6701 | |
| 50 | V | A | 1.5934 | |
| 51 | P | A | 0.1641 | |
| 52 | K | A | -0.9064 | |
| 53 | V | A | 0.0000 | |
| 54 | S | A | 0.0000 | |
| 55 | A | A | 0.0000 | |
| 56 | Y | A | 0.0000 | |
| 57 | Q | A | 0.0000 | |
| 58 | W | A | 0.0000 | |
| 59 | R | A | 0.0000 | |
| 60 | V | A | 0.0000 | |
| 61 | F | A | 0.0000 | |
| 62 | L | A | 0.0000 | |
| 63 | L | A | 0.0000 | |
| 64 | T | A | -1.3071 | |
| 65 | L | A | 0.0000 | |
| 66 | P | A | -1.2507 | |
| 67 | D | A | -1.1397 | |
| 68 | P | A | 0.0000 | |
| 69 | N | A | -1.0579 | |
| 70 | T | A | -0.5339 | |
| 71 | M | A | -0.2693 | |
| 72 | P | A | -0.1696 | |
| 73 | L | A | 0.0254 | |
| 74 | P | A | -0.2981 | |
| 75 | S | A | -0.5350 | |
| 76 | S | A | -0.9552 | |
| 77 | D | A | -1.5488 | |
| 78 | F | A | -0.2616 | |
| 79 | L | A | -0.7726 | |
| 80 | D | A | -1.7831 | |
| 81 | P | A | -1.1301 | |
| 82 | A | A | -0.5741 | |
| 83 | T | A | -0.7984 | |
| 84 | E | A | -0.9887 | |
| 85 | I | A | 0.0000 | |
| 86 | R | A | -0.5698 | |
| 87 | I | A | 0.0000 | |
| 88 | W | A | 0.0000 | |
| 89 | Q | A | -0.3521 | |
| 90 | L | A | 0.0000 | |
| 91 | K | A | -0.6774 | |
| 92 | A | A | 0.0000 | |
| 93 | I | A | 0.0000 | |
| 94 | K | A | 0.0000 | |
| 95 | I | A | 0.0000 | |
| 96 | H | A | -0.2818 | |
| 97 | R | A | 0.0000 | |
| 98 | F | A | 0.5895 | |
| 99 | G | A | -0.3054 | |
| 100 | P | A | -0.2924 | |
| 101 | L | A | -0.1316 | |
| 102 | G | A | -0.5749 | |
| 103 | T | A | -0.6147 | |
| 104 | G | A | 0.0000 | |
| 105 | T | A | -0.2927 | |
| 106 | Y | A | 0.0000 | |
| 107 | G | A | -0.7797 | |
| 108 | H | A | -1.3014 | |
| 109 | A | A | -1.2016 | |
| 110 | N | A | -2.2162 | |
| 111 | F | A | 0.0000 | |
| 112 | N | A | 0.0000 | |
| 113 | R | A | -0.7744 | |
| 114 | F | A | -0.7695 | |
| 115 | G | A | 0.0000 | |
| 116 | D | A | -1.6484 | |
| 117 | V | A | -1.4119 | |
| 118 | D | A | -2.5809 | |
| 119 | N | A | -2.5662 | |
| 120 | P | A | -1.7558 | |
| 121 | T | A | -1.4922 | |
| 122 | E | A | -2.0901 | |
| 123 | Y | A | -0.6510 | |
| 124 | Q | A | -1.2896 | |
| 125 | H | A | -1.5816 | |
| 126 | E | A | -1.8982 | |
| 127 | G | A | -1.8575 | |
| 128 | A | A | -1.4198 | |
| 129 | D | A | -2.5520 | |
| 130 | D | A | -2.1888 | |
| 131 | R | A | -2.1623 | |
| 132 | V | A | -1.2289 | |
| 133 | N | A | -1.5300 | |
| 134 | Y | A | -0.8078 | |
| 135 | S | A | -0.4822 | |
| 136 | F | A | 0.0000 | |
| 137 | T | A | -0.1356 | |
| 138 | P | A | 0.0000 | |
| 139 | K | A | 0.0000 | |
| 140 | K | A | 0.0000 | |
| 141 | L | A | 0.0000 | |
| 142 | Q | A | 0.0000 | |
| 143 | S | A | 0.0000 | |
| 144 | Y | A | 0.0000 | |
| 145 | I | A | 0.0000 | |
| 146 | I | A | 0.0000 | |
| 147 | G | A | 0.0000 | |
| 148 | D | A | 0.0000 | |
| 149 | E | A | -0.4253 | |
| 150 | P | A | 0.0000 | |
| 151 | P | A | 0.0000 | |
| 152 | I | A | -0.0428 | |
| 153 | G | A | 0.0000 | |
| 154 | K | A | -0.4290 | |
| 155 | Y | A | -0.5059 | |
| 156 | T | A | -1.0936 | |
| 157 | A | A | 0.0000 | |
| 158 | K | A | -2.5290 | |
| 159 | A | A | -2.3763 | |
| 160 | E | A | -2.8482 | |
| 161 | P | A | -1.8686 | |
| 162 | K | A | -2.2870 | |
| 163 | P | A | -1.3954 | |
| 164 | G | A | -0.7392 | |
| 165 | L | A | 0.1008 | |
| 166 | P | A | 0.0076 | |
| 167 | P | A | -0.2024 | |
| 168 | G | A | 0.1964 | |
| 169 | A | A | 1.2421 | |
| 170 | I | A | 2.3146 | |
| 171 | P | A | 0.0148 | |
| 172 | P | A | -0.8884 | |
| 173 | T | A | -1.4124 | |
| 174 | K | A | -2.2130 | |
| 175 | T | A | -1.0688 | |
| 176 | V | A | -0.5376 | |
| 177 | T | A | -0.2467 | |
| 178 | T | A | 0.0177 | |
| 179 | I | A | -0.0212 | |
| 180 | I | A | 0.0000 | |
| 181 | E | A | -0.5954 | |
| 182 | D | A | -0.7087 | |
| 183 | G | A | -0.4515 | |
| 184 | D | A | -0.4528 | |
| 185 | M | A | 0.0000 | |
| 186 | A | A | 0.0000 | |
| 187 | D | A | -0.1890 | |
| 188 | I | A | 0.0000 | |
| 189 | G | A | -0.7794 | |
| 190 | F | A | -0.0617 | |
| 191 | G | A | -0.2495 | |
| 192 | A | A | -0.3016 | |
| 193 | K | A | -1.1373 | |
| 194 | N | A | -1.5748 | |
| 195 | F | A | 0.0000 | |
| 196 | K | A | -3.3903 | |
| 197 | E | A | -2.7351 | |
| 198 | L | A | -1.6113 | |
| 199 | E | A | -1.8871 | |
| 200 | P | A | -1.8483 | |
| 201 | S | A | -1.4138 | |
| 202 | K | A | -2.6905 | |
| 203 | D | A | 0.0000 | |
| 204 | E | A | -1.2038 | |
| 205 | V | A | 0.0000 | |
| 206 | P | A | 0.0000 | |
| 207 | D | A | -1.7142 | |
| 208 | D | A | 0.0000 | |
| 209 | I | A | 0.0000 | |
| 210 | L | A | -1.7157 | |
| 211 | N | A | -2.5554 | |
| 212 | T | A | -1.3730 | |
| 213 | T | A | -1.0266 | |
| 214 | T | A | 0.0000 | |
| 215 | K | A | 0.0000 | |
| 216 | V | A | 0.1598 | |
| 217 | I | A | 0.0000 | |
| 218 | D | A | -0.9469 | |
| 219 | Y | A | -1.3370 | |
| 220 | E | A | -2.4606 | |
| 221 | G | A | -1.7167 | |
| 222 | M | A | 0.0000 | |
| 223 | K | A | -2.6062 | |
| 224 | A | A | -1.5570 | |
| 225 | E | A | -1.4139 | |
| 226 | P | A | -0.8897 | |
| 227 | Y | A | 0.0000 | |
| 228 | G | A | 0.0000 | |
| 229 | R | A | -0.7419 | |
| 230 | R | A | -0.6104 | |
| 231 | M | A | 0.0000 | |
| 232 | F | A | 0.0000 | |
| 233 | T | A | -0.5562 | |
| 234 | H | A | -0.6779 | |
| 235 | D | A | -0.8849 | |
| 236 | S | A | -0.8158 | |
| 237 | Y | A | -1.0086 | |
| 238 | E | A | -2.2196 | |
| 239 | K | A | -2.6233 | |
| 240 | S | A | -2.3935 | |
| 241 | K | A | -3.0604 | |
| 242 | D | A | -2.7230 | |
| 243 | V | A | -1.1499 | |
| 244 | K | A | -2.1833 | |
| 245 | K | A | -2.2351 | |
| 246 | L | A | 0.0000 | |
| 247 | R | A | 0.0000 | |
| 248 | R | A | 0.0000 | |
| 249 | S | A | -1.2860 | |
| 250 | G | A | -0.8995 | |
| 251 | P | A | -0.4060 | |
| 252 | D | A | 0.1703 | |
| 253 | L | A | 1.8731 | |
| 254 | I | A | 2.5060 | |
| 255 | P | A | 0.4906 | |
| 256 | L | A | 0.2165 | |
| 257 | P | A | -0.6996 | |
| 258 | D | A | -1.8983 | |
| 259 | A | A | -1.2521 | |
| 260 | P | A | -1.1989 | |
| 261 | P | A | -0.9646 | |
| 262 | P | A | -0.5920 | |
| 263 | S | A | -0.7850 | |
| 264 | R | A | -0.8725 | |
| 265 | L | A | 0.7298 | |
| 266 | Y | A | 0.7204 | |
| 267 | V | A | 0.6939 | |
| 268 | R | A | -0.9665 | |
| 269 | P | A | 0.0206 | |
| 270 | P | A | 0.0315 | |
| 271 | P | A | 0.3860 | |
| 272 | W | A | 1.3114 | |
| 273 | S | A | 0.0000 | |
| 274 | P | A | 0.6762 | |
| 275 | Y | A | 1.0721 | |
| 276 | A | A | 0.8703 | |
| 277 | V | A | 1.2689 | |
| 278 | R | A | -0.2885 | |
| 279 | P | A | -0.6387 | |
| 280 | S | A | 0.0000 | |
| 281 | T | A | -0.5225 | |
| 282 | D | A | -1.0610 | |
| 283 | Y | A | 0.2838 | |
| 284 | F | A | -0.2136 | |
| 285 | T | A | -1.0553 | |
| 286 | I | A | 0.0000 | |
| 287 | P | A | 0.0000 | |
| 288 | D | A | -1.7904 | |
| 289 | R | A | 0.0000 | |
| 290 | G | A | -1.8966 | |
| 291 | E | A | -2.4614 | |
| 292 | I | A | -1.3940 | |
| 293 | N | A | -2.1574 | |
| 294 | E | A | -2.4366 | |
| 295 | S | A | -1.4703 | |
| 296 | D | A | -1.1497 | |
| 297 | L | A | -0.9201 | |
| 298 | L | A | -0.5634 | |
| 299 | F | A | 0.0000 | |
| 300 | N | A | -1.0015 | |
| 301 | K | A | -1.2822 | |
| 302 | P | A | -0.6636 | |
| 303 | Y | A | -0.1643 | |
| 304 | F | A | -0.5002 | |
| 305 | L | A | 0.0000 | |
| 306 | E | A | -2.5698 | |
| 307 | K | A | -2.7479 | |
| 308 | T | A | 0.0000 | |
| 309 | P | A | -1.1126 | |
| 310 | G | A | -1.2359 | |
| 311 | K | A | -1.1404 | |
| 312 | N | A | 0.0000 | |
| 313 | Q | A | -1.2561 | |
| 314 | G | A | 0.0000 | |
| 315 | V | A | 0.0000 | |
| 316 | L | A | 0.0000 | |
| 317 | W | A | 0.0000 | |
| 318 | G | A | -0.6902 | |
| 319 | N | A | -0.7711 | |
| 320 | R | A | -0.9586 | |
| 321 | L | A | 0.0000 | |
| 322 | Y | A | 0.0000 | |
| 323 | I | A | 0.0000 | |
| 324 | T | A | 0.0000 | |
| 325 | I | A | 0.0000 | |
| 326 | L | A | 0.0000 | |
| 327 | D | A | 0.0000 | |
| 328 | N | A | 0.0000 | |
| 329 | T | A | 0.0000 | |
| 330 | R | A | 0.0000 | |
| 331 | D | A | 0.0000 | |
| 332 | E | A | -1.4096 | |
| 333 | I | A | -0.8068 | |
| 334 | A | A | -0.7963 | |
| 335 | T | A | -0.9904 | |
| 336 | H | A | -0.7744 | |
| 337 | T | A | -0.1382 | |
| 338 | T | A | 0.2567 | |
| 339 | Q | A | 0.1422 | |
| 340 | I | A | 1.7511 | |
| 341 | S | A | 0.5794 | |
| 342 | T | A | -0.2314 | |
| 343 | P | A | -0.2339 | |
| 344 | A | A | -0.5426 | |
| 345 | E | A | -1.6939 | |
| 346 | N | A | -1.0625 | |
| 347 | V | A | 1.0238 | |
| 348 | Y | A | 1.1543 | |
| 349 | D | A | -0.0247 | |
| 350 | P | A | -0.0688 | |
| 351 | S | A | 0.0571 | |
| 352 | N | A | 0.3736 | |
| 353 | Y | A | 0.8934 | |
| 354 | V | A | 1.4549 | |
| 355 | T | A | -0.0369 | |
| 356 | S | A | -0.6994 | |
| 357 | K | A | -1.4708 | |
| 358 | T | A | -0.9061 | |
| 359 | Y | A | 0.0000 | |
| 360 | T | A | -0.4427 | |
| 361 | E | A | 0.0000 | |
| 362 | Q | A | 0.0940 | |
| 363 | Y | A | 0.0000 | |
| 364 | K | A | -0.3650 | |
| 365 | I | A | 0.0000 | |
| 366 | S | A | 0.0000 | |
| 367 | L | A | 0.0000 | |
| 368 | I | A | 0.0000 | |
| 369 | V | A | 0.0000 | |
| 370 | Q | A | -0.4404 | |
| 371 | L | A | 0.0000 | |
| 372 | C | A | 0.0000 | |
| 373 | T | A | 0.0000 | |
| 374 | I | A | 0.0000 | |
| 375 | P | A | -0.6431 | |
| 376 | L | A | -0.3725 | |
| 377 | T | A | -0.7103 | |
| 378 | P | A | -1.0267 | |
| 379 | E | A | -1.8345 | |
| 380 | T | A | 0.0000 | |
| 381 | L | A | -0.4223 | |
| 382 | A | A | -0.6809 | |
| 383 | E | A | 0.0000 | |
| 384 | L | A | 0.0000 | |
| 385 | A | A | -0.2992 | |
| 386 | R | A | -0.6986 | |
| 387 | L | A | -0.2992 | |
| 388 | D | A | -0.4102 | |
| 389 | P | A | -0.4536 | |
| 390 | S | A | -0.4014 | |
| 391 | F | A | 0.0000 | |
| 392 | L | A | 0.0424 | |
| 393 | V | A | -0.0452 | |
| 394 | R | A | -0.9151 | |
| 395 | A | A | -0.9595 | |
| 396 | Q | A | -0.8477 | |
| 397 | L | A | 0.0000 | |
| 398 | P | A | 0.3839 | |
| 399 | F | A | 1.7392 | |
| 400 | V | A | 0.9877 | |
| 401 | P | A | 0.2596 | |
| 402 | P | A | -0.0032 | |
| 403 | V | A | 0.5328 | |
| 404 | E | A | -1.1874 | |
| 405 | T | A | -0.7365 | |
| 406 | A | A | -0.6039 | |
| 407 | D | A | -1.1266 | |
| 408 | P | A | -0.6913 | |
| 409 | Y | A | -0.5432 | |
| 410 | A | A | -0.6481 | |
| 411 | G | A | -0.8965 | |
| 412 | K | A | -1.0776 | |
| 413 | T | A | -0.8548 | |
| 414 | F | A | 0.0000 | |
| 415 | L | A | -0.7869 | |
| 416 | K | A | -1.9165 | |
| 417 | L | A | -1.6447 | |
| 418 | D | A | -2.5150 | |
| 419 | L | A | 0.0000 | |
| 420 | T | A | -1.6811 | |
| 421 | D | A | -2.3051 | |
| 422 | K | A | -1.8218 | |
| 423 | L | A | -0.7492 | |
| 424 | S | A | -0.4698 | |
| 425 | S | A | -0.3501 | |
| 426 | N | A | -0.7597 | |
| 427 | L | A | 0.0000 | |
| 428 | S | A | -0.1822 | |
| 429 | L | A | 0.6506 | |
| 430 | T | A | -0.3679 | |
| 431 | E | A | -1.3000 | |
| 432 | L | A | 0.0000 | |
| 433 | G | A | 0.0000 | |
| 434 | R | A | -1.7176 | |
| 435 | E | A | -1.7392 | |
| 436 | Y | A | -0.7625 | |
| 437 | L | A | -0.1323 | |
| 438 | N | A | -1.7788 | |
| 439 | K | A | -1.9855 |
ALA alanine
ARG arginine
ASN asparagine
ASP aspartic acid
CYS cysteine
GLN glutamine
GLU glutamic acid
GLY glycine
HIS histidine
ILE isoleucine
LEU leucine
LYS lysine
MET methionine
PHE phenylalanine
PRO proline
SER serine
THR threonine
TRP tryptophan
TYR tyrosine
VAL valine