Chain sequence(s) |
H: EVQLVESGAEVKKPGSSSVKVSCRASGTFYKYAINWVRQAPGQGLEWMMGGIIPFFGTTNYAQKFQGRLTITADGSTNTAYMMQLDSLRSEDTAVYYCAGPSITESHYCLDCAAKDYYYGLDVWGQGTTVTVSSSASTKGPSVFPLAPSGTAALGCLVKDYFPEPVTVSWNSGALTSGVHTFPAVLQSSGLYSSLSSVVTVPSSSLGTQTYICNVNHKPSNTTKVDKKVEPKSCHHHHHH
L: QSVLTQPPSASGTPGQSVTISCSSGSRSNIGGNTVNWYQHLPGMAPKLLIYSSSNQRRSSSGVVPDDRFSSGSKSGTSSASSLAISGLQSEDDDADYYCASSWDDSLNGVVFGGGTKLTVLGQPKAAPSSVTLFPPSSEELQANKATLVCLISSDFYPGAVTVAWKADSSPVKAGVETTTPSSKQSNNKYAASSSYLSLTPEQWKSHKSYSCQVTHEGSSTVEKTVAPTEC input PDB |
Selected Chain(s) | H,L |
Distance of aggregation | 10 Å |
FoldX usage | Yes |
Dynamic mode | No |
Automated mutations | No |
Downloads | Download all the data |
Simulation log |
[INFO] Logger: Verbosity set to: 2 - [INFO] (00:00:00) [WARNING] runJob: Working directory already exists (possibly overwriting previous results -ow to prevent this behavior) (00:00:00) [INFO] runJob: Starting aggrescan3d job on: input.pdb with all chain(s) selected (00:00:00) [INFO] runJob: Creating pdb object from: input.pdb (00:00:00) [INFO] FoldX: Starting FoldX energy minimalization (00:00:00) [INFO] Analysis: Starting Aggrescan3D on folded.pdb (00:04:56) [INFO] Main: Simulation completed successfully. (00:04:59) |
The table below lists A3D score for protein residues. Residues with A3D score > 0.0000 are marked by yellow rows.
residue index | residue name | chain | Aggrescan3D score | mutation |
---|---|---|---|---|
residue index | residue name | chain | Aggrescan3D score | |
1 | Q | L | -0.9842 | |
2 | S | L | -0.2482 | |
3 | V | L | 0.9048 | |
4 | L | L | 0.0000 | |
5 | T | L | -0.2396 | |
6 | Q | L | 0.0000 | |
7 | P | L | -0.5017 | |
8 | P | L | -0.7221 | |
9 | S | L | -0.7254 | |
11 | A | L | -0.4752 | |
12 | S | L | -0.2511 | |
13 | G | L | -0.4356 | |
14 | T | L | -0.5345 | |
15 | P | L | -1.0133 | |
16 | G | L | -1.4074 | |
17 | Q | L | -1.6192 | |
18 | S | L | -1.0211 | |
19 | V | L | -0.2788 | |
20 | T | L | -0.1197 | |
21 | I | L | 0.0000 | |
22 | S | L | -0.3226 | |
23 | C | L | 0.0000 | |
24 | S | L | -0.2608 | |
25 | G | L | -0.4549 | |
26 | S | L | -1.1061 | |
27 | R | L | -2.3942 | |
27A | S | L | -1.5467 | |
27B | N | L | 0.0000 | |
28 | I | L | 0.0000 | |
29 | G | L | -1.5857 | |
30 | G | L | -1.3664 | |
31 | N | L | -0.9663 | |
32 | T | L | -0.4345 | |
33 | V | L | 0.0000 | |
34 | N | L | -0.3423 | |
35 | W | L | 0.0000 | |
36 | Y | L | 0.0000 | |
37 | Q | L | -0.7046 | |
38 | H | L | 0.0000 | |
39 | L | L | -0.2397 | |
40 | P | L | -0.2039 | |
41 | G | L | -0.1423 | |
42 | M | L | 0.4276 | |
43 | A | L | -0.1012 | |
44 | P | L | 0.0000 | |
45 | K | L | -1.3085 | |
46 | L | L | 0.0000 | |
47 | L | L | 0.0000 | |
48 | I | L | 0.0000 | |
49 | Y | L | -0.5321 | |
50 | S | L | -0.7541 | |
51 | S | L | 0.0000 | |
52 | N | L | -2.1082 | |
53 | Q | L | -2.1700 | |
54 | R | L | -2.3874 | |
55 | S | L | -1.4146 | |
56 | S | L | -0.9841 | |
57 | G | L | -1.0443 | |
58 | V | L | 0.0000 | |
59 | P | L | -1.5224 | |
60 | D | L | -2.4291 | |
61 | R | L | -1.4826 | |
62 | F | L | 0.0000 | |
63 | S | L | -1.4593 | |
64 | G | L | -1.2093 | |
65 | S | L | -1.1548 | |
66 | K | L | -1.2195 | |
67 | S | L | -0.8066 | |
68 | G | L | -1.1813 | |
69 | T | L | -1.1839 | |
70 | S | L | -0.8494 | |
71 | A | L | 0.0000 | |
72 | S | L | -0.5774 | |
73 | L | L | 0.0000 | |
74 | A | L | -0.1944 | |
75 | I | L | 0.0000 | |
76 | S | L | -1.1171 | |
77 | G | L | -1.1070 | |
78 | L | L | 0.0000 | |
79 | Q | L | -1.5090 | |
80 | S | L | -1.5097 | |
81 | E | L | -2.2501 | |
82 | D | L | 0.0000 | |
83 | D | L | 0.0000 | |
84 | A | L | 0.0000 | |
85 | D | L | -0.8832 | |
86 | Y | L | 0.0000 | |
87 | Y | L | 0.0000 | |
88 | C | L | 0.0000 | |
89 | A | L | 0.0000 | |
90 | S | L | 0.0000 | |
91 | W | L | 0.0000 | |
92 | D | L | 0.0000 | |
93 | D | L | -1.6153 | |
94 | S | L | -0.6985 | |
95 | L | L | 0.1261 | |
95A | N | L | -1.2528 | |
95B | G | L | 0.0000 | |
96 | V | L | 0.0218 | |
97 | V | L | 0.0000 | |
98 | F | L | 0.0000 | |
99 | G | L | 0.0000 | |
100 | G | L | -0.9232 | |
101 | G | L | -0.8660 | |
102 | T | L | 0.0000 | |
103 | K | L | -1.0873 | |
104 | L | L | 0.0000 | |
105 | T | L | -0.3306 | |
106 | V | L | 0.0000 | |
106A | L | L | 0.7049 | |
107 | G | L | -0.3585 | |
108 | Q | L | -0.7801 | |
109 | P | L | -1.1760 | |
110 | K | L | -2.2038 | |
111 | A | L | -1.3197 | |
112 | A | L | -0.6603 | |
113 | P | L | -0.3425 | |
114 | S | L | -0.4044 | |
115 | V | L | -0.3683 | |
116 | T | L | -0.3950 | |
117 | L | L | 0.0000 | |
118 | F | L | 0.0000 | |
119 | P | L | -0.2602 | |
120 | P | L | 0.0000 | |
121 | S | L | -0.7504 | |
122 | S | L | -1.5680 | |
123 | E | L | -2.2022 | |
124 | E | L | 0.0000 | |
125 | L | L | -1.8242 | |
126 | Q | L | -2.5506 | |
127 | A | L | -1.7496 | |
128 | N | L | -2.5642 | |
129 | K | L | -2.4608 | |
130 | A | L | 0.0000 | |
131 | T | L | 0.0000 | |
132 | L | L | 0.0000 | |
133 | V | L | 0.0000 | |
134 | C | L | 0.0000 | |
135 | L | L | 0.0000 | |
136 | I | L | 0.0000 | |
137 | S | L | -0.5526 | |
138 | D | L | -1.1910 | |
139 | F | L | 0.0000 | |
140 | Y | L | -1.1018 | |
141 | P | L | -0.8598 | |
142 | G | L | -0.7023 | |
143 | A | L | -0.2426 | |
144 | V | L | -0.1665 | |
145 | T | L | -0.1351 | |
146 | V | L | 0.2199 | |
147 | A | L | -0.3769 | |
148 | W | L | 0.0000 | |
149 | K | L | -0.9223 | |
150 | A | L | 0.0000 | |
151 | D | L | -1.5275 | |
152 | S | L | -0.9803 | |
153 | S | L | -0.8318 | |
154 | P | L | -0.8759 | |
155 | V | L | -0.8124 | |
156 | K | L | -1.6077 | |
157 | A | L | -0.7413 | |
158 | G | L | -0.5030 | |
159 | V | L | -0.1761 | |
160 | E | L | -0.0789 | |
161 | T | L | 0.1703 | |
162 | T | L | 0.1310 | |
163 | T | L | -0.1162 | |
164 | P | L | -0.2713 | |
165 | S | L | -0.4704 | |
166 | K | L | -1.0127 | |
167 | Q | L | -1.2679 | |
168 | S | L | -1.4366 | |
169 | N | L | -2.1251 | |
170 | N | L | -1.8209 | |
171 | K | L | -1.7319 | |
172 | Y | L | -0.8358 | |
173 | A | L | 0.0000 | |
174 | A | L | 0.0000 | |
175 | S | L | 0.0000 | |
176 | S | L | 0.0000 | |
177 | Y | L | 0.0000 | |
178 | L | L | 0.0000 | |
179 | S | L | -0.4177 | |
180 | L | L | -1.0419 | |
181 | T | L | -1.7602 | |
182 | P | L | 0.0000 | |
183 | E | L | -3.1477 | |
184 | Q | L | -2.3568 | |
185 | W | L | 0.0000 | |
186 | K | L | -3.0554 | |
187 | S | L | -2.4128 | |
188 | H | L | -2.3785 | |
189 | K | L | -2.4366 | |
190 | S | L | -1.5793 | |
191 | Y | L | 0.0000 | |
192 | S | L | 0.0000 | |
193 | C | L | 0.0000 | |
194 | Q | L | -0.6911 | |
195 | V | L | 0.0000 | |
196 | T | L | -0.5431 | |
197 | H | L | 0.0000 | |
198 | E | L | -2.2817 | |
199 | G | L | -1.4563 | |
200 | S | L | -0.7860 | |
201 | T | L | -0.3945 | |
202 | V | L | -0.0410 | |
203 | E | L | -1.4066 | |
204 | K | L | -1.5780 | |
205 | T | L | -1.0354 | |
206 | V | L | 0.0000 | |
207 | A | L | -1.1849 | |
208 | P | L | -1.2557 | |
209 | T | L | -0.9477 | |
210 | E | L | -0.9836 | |
211 | C | L | -0.1890 | |
1 | E | H | -1.9661 | |
2 | V | H | -1.5101 | |
3 | Q | H | -1.5480 | |
4 | L | H | 0.0000 | |
5 | V | H | 0.4839 | |
6 | E | H | 0.0000 | |
7 | S | H | -0.4862 | |
8 | G | H | -0.6703 | |
9 | A | H | -0.7040 | |
10 | E | H | -0.9557 | |
11 | V | H | -0.6905 | |
12 | K | H | -1.5894 | |
13 | K | H | -2.5034 | |
14 | P | H | -2.1599 | |
15 | G | H | -1.7421 | |
16 | S | H | -1.4482 | |
17 | S | H | -1.4816 | |
18 | V | H | 0.0000 | |
19 | K | H | -1.8929 | |
20 | V | H | 0.0000 | |
21 | S | H | -0.5792 | |
22 | C | H | 0.0000 | |
23 | R | H | -1.6108 | |
24 | A | H | 0.0000 | |
25 | S | H | -1.0523 | |
26 | G | H | -0.8753 | |
27 | T | H | -0.1484 | |
28 | F | H | -0.2845 | |
29 | Y | H | 0.3280 | |
30 | K | H | -0.1035 | |
31 | Y | H | 0.1445 | |
32 | A | H | 0.0000 | |
33 | I | H | 0.0000 | |
34 | N | H | 0.0000 | |
36 | W | H | 0.0000 | |
37 | V | H | 0.0000 | |
38 | R | H | 0.0000 | |
39 | Q | H | -0.6708 | |
40 | A | H | -1.1103 | |
41 | P | H | -1.0866 | |
42 | G | H | -1.2362 | |
43 | Q | H | -1.7611 | |
44 | G | H | -1.2450 | |
45 | L | H | 0.0000 | |
46 | E | H | -0.7453 | |
47 | W | H | 0.0000 | |
48 | M | H | 0.0000 | |
49 | G | H | 0.0000 | |
50 | G | H | 0.0000 | |
51 | I | H | 0.0000 | |
52 | I | H | 0.0000 | |
52A | P | H | 0.0000 | |
53 | F | H | 1.1662 | |
54 | F | H | 1.0416 | |
55 | G | H | 0.2320 | |
56 | T | H | 0.1665 | |
57 | T | H | -0.0466 | |
58 | N | H | -0.5043 | |
59 | Y | H | -0.8316 | |
60 | A | H | -1.3050 | |
61 | Q | H | -2.3558 | |
62 | K | H | -2.6428 | |
63 | F | H | 0.0000 | |
64 | Q | H | -2.2714 | |
65 | G | H | -1.4914 | |
66 | R | H | 0.0000 | |
67 | L | H | 0.0000 | |
68 | T | H | -0.6620 | |
69 | I | H | 0.0000 | |
70 | T | H | -0.2620 | |
71 | A | H | -0.3714 | |
72 | D | H | -1.0074 | |
73 | G | H | -0.5790 | |
74 | S | H | -0.5898 | |
75 | T | H | -0.9377 | |
76 | N | H | -1.1291 | |
77 | T | H | 0.0000 | |
78 | A | H | 0.0000 | |
79 | Y | H | -0.5732 | |
80 | M | H | 0.0000 | |
81 | Q | H | -1.2060 | |
82 | L | H | 0.0000 | |
82A | D | H | -1.3656 | |
82B | S | H | -1.3059 | |
82C | L | H | 0.0000 | |
83 | R | H | -2.9186 | |
84 | S | H | -2.2698 | |
85 | E | H | -2.4638 | |
86 | D | H | 0.0000 | |
87 | T | H | -0.9796 | |
88 | A | H | 0.0000 | |
89 | V | H | 0.2079 | |
90 | Y | H | 0.0000 | |
91 | Y | H | 0.0000 | |
92 | C | H | 0.0000 | |
93 | A | H | 0.0000 | |
94 | G | H | 0.0000 | |
95 | P | H | 0.0000 | |
96 | S | H | -0.2713 | |
97 | I | H | -0.0587 | |
98 | T | H | -0.7423 | |
99 | E | H | -1.6881 | |
100 | S | H | -1.3580 | |
100A | H | H | -1.2847 | |
100B | Y | H | -0.6672 | |
100C | C | H | -0.2151 | |
100D | L | H | 0.9658 | |
100E | D | H | -0.8286 | |
100F | C | H | -0.4398 | |
100G | A | H | -0.5103 | |
100H | A | H | -0.8186 | |
100I | K | H | -1.3232 | |
100J | D | H | -1.4122 | |
100K | Y | H | 0.0000 | |
100L | Y | H | -0.0519 | |
100M | Y | H | 0.2862 | |
100N | G | H | 0.0257 | |
100O | L | H | 0.0000 | |
101 | D | H | -0.9788 | |
102 | V | H | -1.0409 | |
103 | W | H | -0.3331 | |
104 | G | H | 0.0000 | |
105 | Q | H | -0.6791 | |
106 | G | H | -0.1608 | |
107 | T | H | 0.0000 | |
108 | T | H | -0.1960 | |
109 | V | H | 0.0000 | |
110 | T | H | -0.8277 | |
111 | V | H | 0.0000 | |
112 | S | H | -1.2026 | |
113 | S | H | -0.9516 | |
114 | A | H | -0.5307 | |
115 | S | H | -0.5623 | |
116 | T | H | -0.6449 | |
117 | K | H | -0.9977 | |
118 | G | H | -1.2273 | |
119 | P | H | -0.4800 | |
120 | S | H | -0.2026 | |
121 | V | H | 0.0000 | |
122 | F | H | -0.4634 | |
123 | P | H | -0.7837 | |
124 | L | H | 0.0000 | |
125 | A | H | -0.8429 | |
126 | P | H | 0.0000 | |
127 | S | H | -0.4072 | |
134 | G | H | -0.6366 | |
135 | T | H | -0.4884 | |
136 | A | H | -0.2910 | |
137 | A | H | -0.1148 | |
138 | L | H | 0.0000 | |
139 | G | H | 0.0000 | |
140 | C | H | 0.0000 | |
141 | L | H | 0.0000 | |
142 | V | H | 0.0000 | |
143 | K | H | 0.0000 | |
144 | D | H | -0.1978 | |
145 | Y | H | 0.0000 | |
146 | F | H | -0.0573 | |
147 | P | H | 0.0000 | |
148 | E | H | -0.5001 | |
149 | P | H | -0.6781 | |
150 | V | H | -0.5437 | |
151 | T | H | -0.4736 | |
152 | V | H | -0.2664 | |
153 | S | H | -0.3148 | |
154 | W | H | 0.0000 | |
155 | N | H | -0.7348 | |
156 | S | H | -0.6379 | |
157 | G | H | -0.4667 | |
158 | A | H | -0.2104 | |
159 | L | H | 0.0257 | |
160 | T | H | -0.1705 | |
161 | S | H | -0.2559 | |
162 | G | H | -0.3553 | |
163 | V | H | 0.1704 | |
164 | H | H | -0.1963 | |
165 | T | H | -0.0890 | |
166 | F | H | 0.0000 | |
167 | P | H | -0.0590 | |
168 | A | H | 0.2986 | |
169 | V | H | 0.0000 | |
170 | L | H | 1.3596 | |
171 | Q | H | 0.4364 | |
172 | S | H | -0.0607 | |
173 | S | H | -0.1480 | |
174 | G | H | 0.1152 | |
175 | L | H | 0.2881 | |
176 | Y | H | 0.5585 | |
177 | S | H | 0.0000 | |
178 | L | H | 0.0000 | |
179 | S | H | 0.0000 | |
180 | S | H | 0.0000 | |
181 | V | H | 0.0000 | |
182 | V | H | 0.0000 | |
183 | T | H | -0.2299 | |
184 | V | H | 0.0000 | |
185 | P | H | -0.5374 | |
186 | S | H | -0.5210 | |
187 | S | H | -0.6162 | |
188 | S | H | -0.6399 | |
189 | L | H | -0.8318 | |
190 | G | H | -1.0202 | |
191 | T | H | -0.8530 | |
192 | Q | H | -1.5362 | |
193 | T | H | -1.1129 | |
194 | Y | H | 0.0000 | |
195 | I | H | -0.8620 | |
196 | C | H | 0.0000 | |
197 | N | H | -1.4075 | |
198 | V | H | 0.0000 | |
199 | N | H | -1.7120 | |
200 | H | H | 0.0000 | |
201 | K | H | -2.6974 | |
202 | P | H | -1.5778 | |
203 | S | H | -1.7270 | |
204 | N | H | -2.4806 | |
205 | T | H | -1.9973 | |
206 | K | H | -2.5982 | |
207 | V | H | -1.4785 | |
208 | D | H | -2.4165 | |
209 | K | H | -1.7477 | |
210 | K | H | -1.9600 | |
211 | V | H | 0.0000 | |
212 | E | H | -2.4867 | |
213 | P | H | -1.2927 | |
214 | K | H | -1.4228 | |
215 | S | H | -1.3413 | |
216 | C | H | -0.7968 | |
217 | H | H | -1.6357 | |
218 | H | H | -2.3268 | |
219 | H | H | -2.4524 | |
220 | H | H | -2.8368 | |
221 | H | H | -2.6901 | |
222 | H | H | -1.9470 |