| Chain sequence(s) |
A: GPPASNPEPKLRSTSEYVTPTDLLYIAETDLITETGNPFEDIVVNGEVVIPKVSANQWKVFHLTLPDPNTLPLPSADFIDRSTHILIWRLKALKIEVFGPLGKGSYGHPNFNAFGDVDNPTEYQKETEDVTVDFSFRPKLLQEYIVGDRPPTAKYTAKAAPDPGLPPGATPPLTTVTTTIEHGDMADIGFGAKDFKELEPRKNDVPLDILNTTTKVPDYEGMKAEPTGRRMFDYDRKESSKDIKKLRRSGPEKFPLPDAPPPSKLYIKPPPSSPYYERPSTDYFTIPDEGEITEEDLLFNKPKFFDKTEGLNNGVLWHNRLYITILDNRRSEIEVHTTQLSTPEPNVFNPANYVTSYSYTREYKISLIVQLCKIPLTPETLELISRIDPSILVDANLPFIPPVERPDPLAGKKFIEIDLTDKLSTNLEEFPLGREYLNR
input PDB |
| Selected Chain(s) | A |
| Distance of aggregation | 10 Å |
| FoldX usage | No |
| Dynamic mode | No |
| Automated mutations | No |
| Downloads | Download all the data |
| Simulation log |
[INFO] Logger: Verbosity set to: 2 - [INFO] (00:00:01)
[WARNING] runJob: Working directory already exists (possibly overwriting previous results -ow
to prevent this behavior) (00:00:01)
[INFO] runJob: Starting aggrescan3d job on: input.pdb with A chain(s) selected (00:00:01)
[INFO] runJob: Creating pdb object from: input.pdb (00:00:01)
[INFO] runJob: FoldX not utilized. Treating input pdb file as it was already optimized. (00:00:01)
[INFO] Analysis: Starting Aggrescan3D on folded.pdb (00:00:01)
[INFO] Main: Simulation completed successfully. (00:00:04)
|
The table below lists A3D score for protein residues. Residues with A3D score > 0.0000 are marked by yellow rows.
| residue index | residue name | chain | Aggrescan3D score | mutation |
|---|---|---|---|---|
| residue index | residue name | chain | Aggrescan3D score | |
| 1 | G | A | -0.6463 | |
| 2 | P | A | -0.6150 | |
| 3 | P | A | -0.7116 | |
| 4 | A | A | -0.6790 | |
| 5 | S | A | -1.2453 | |
| 6 | N | A | -2.0294 | |
| 7 | P | A | -2.0951 | |
| 8 | E | A | -2.7853 | |
| 9 | P | A | -2.4128 | |
| 10 | K | A | -2.4821 | |
| 11 | L | A | -1.2547 | |
| 12 | R | A | -1.6432 | |
| 13 | S | A | -1.1136 | |
| 14 | T | A | 0.0000 | |
| 15 | S | A | -1.4074 | |
| 16 | E | A | -2.0951 | |
| 17 | Y | A | 0.0000 | |
| 18 | V | A | 0.0000 | |
| 19 | T | A | -0.6676 | |
| 20 | P | A | -0.7475 | |
| 21 | T | A | -0.9189 | |
| 22 | D | A | -1.6481 | |
| 23 | L | A | -0.5145 | |
| 24 | L | A | -0.2625 | |
| 25 | Y | A | -0.1682 | |
| 26 | I | A | 0.0000 | |
| 27 | A | A | 0.0000 | |
| 28 | E | A | -0.6858 | |
| 29 | T | A | 0.0000 | |
| 30 | D | A | -1.2304 | |
| 31 | L | A | 0.4548 | |
| 32 | I | A | 0.2349 | |
| 33 | T | A | -0.0974 | |
| 34 | E | A | -0.4148 | |
| 35 | T | A | -0.1923 | |
| 36 | G | A | 0.0000 | |
| 37 | N | A | -0.4969 | |
| 38 | P | A | 0.0000 | |
| 39 | F | A | -0.5404 | |
| 40 | E | A | -1.7030 | |
| 41 | D | A | -0.4547 | |
| 42 | I | A | 1.6423 | |
| 43 | V | A | 2.4560 | |
| 44 | V | A | 1.8753 | |
| 45 | N | A | -0.5251 | |
| 46 | G | A | -0.3847 | |
| 47 | E | A | -0.0794 | |
| 48 | V | A | 2.1773 | |
| 49 | V | A | 2.8785 | |
| 50 | I | A | 2.1213 | |
| 51 | P | A | 0.4046 | |
| 52 | K | A | -0.7498 | |
| 53 | V | A | 0.0000 | |
| 54 | S | A | 0.0000 | |
| 55 | A | A | 0.0000 | |
| 56 | N | A | 0.0000 | |
| 57 | Q | A | 0.0000 | |
| 58 | W | A | 0.0000 | |
| 59 | K | A | 0.0000 | |
| 60 | V | A | 0.0000 | |
| 61 | F | A | 0.0000 | |
| 62 | H | A | 0.0000 | |
| 63 | L | A | 0.0000 | |
| 64 | T | A | -1.3569 | |
| 65 | L | A | 0.0000 | |
| 66 | P | A | -1.1372 | |
| 67 | D | A | -1.0501 | |
| 68 | P | A | 0.0000 | |
| 69 | N | A | -0.8599 | |
| 70 | T | A | -0.2948 | |
| 71 | L | A | -0.0928 | |
| 72 | P | A | -0.1177 | |
| 73 | L | A | -0.0836 | |
| 74 | P | A | -0.3547 | |
| 75 | S | A | -0.6706 | |
| 76 | A | A | -1.0504 | |
| 77 | D | A | -2.2518 | |
| 78 | F | A | -1.1894 | |
| 79 | I | A | 0.0000 | |
| 80 | D | A | -3.1960 | |
| 81 | R | A | -3.1235 | |
| 82 | S | A | -1.8044 | |
| 83 | T | A | -1.4194 | |
| 84 | H | A | -1.5803 | |
| 85 | I | A | 0.0000 | |
| 86 | L | A | 0.0000 | |
| 87 | I | A | 0.0000 | |
| 88 | W | A | 0.0000 | |
| 89 | R | A | -0.3518 | |
| 90 | L | A | 0.0000 | |
| 91 | K | A | -0.6678 | |
| 92 | A | A | 0.0000 | |
| 93 | L | A | 0.0000 | |
| 94 | K | A | -0.9267 | |
| 95 | I | A | 0.0000 | |
| 96 | E | A | -0.8118 | |
| 97 | V | A | 0.0000 | |
| 98 | F | A | 0.2832 | |
| 99 | G | A | -0.4746 | |
| 100 | P | A | -0.4742 | |
| 101 | L | A | -0.4730 | |
| 102 | G | A | -1.1632 | |
| 103 | K | A | -1.7361 | |
| 104 | G | A | 0.0000 | |
| 105 | S | A | -0.8241 | |
| 106 | Y | A | 0.0000 | |
| 107 | G | A | -0.5575 | |
| 108 | H | A | 0.0000 | |
| 109 | P | A | -1.3787 | |
| 110 | N | A | -2.0512 | |
| 111 | F | A | 0.0000 | |
| 112 | N | A | 0.0000 | |
| 113 | A | A | 0.0000 | |
| 114 | F | A | 0.0000 | |
| 115 | G | A | 0.0000 | |
| 116 | D | A | -2.2384 | |
| 117 | V | A | -1.7173 | |
| 118 | D | A | -2.7456 | |
| 119 | N | A | -2.7064 | |
| 120 | P | A | -1.8966 | |
| 121 | T | A | -1.5799 | |
| 122 | E | A | -2.2333 | |
| 123 | Y | A | -1.0826 | |
| 124 | Q | A | -2.1340 | |
| 125 | K | A | -2.8505 | |
| 126 | E | A | -2.7380 | |
| 127 | T | A | -2.2403 | |
| 128 | E | A | -2.9877 | |
| 129 | D | A | -2.7114 | |
| 130 | V | A | -1.4659 | |
| 131 | T | A | -1.1461 | |
| 132 | V | A | -0.7121 | |
| 133 | D | A | -1.8566 | |
| 134 | F | A | -0.8467 | |
| 135 | S | A | -0.5126 | |
| 136 | F | A | 0.0000 | |
| 137 | R | A | -0.7775 | |
| 138 | P | A | 0.0000 | |
| 139 | K | A | -1.4372 | |
| 140 | L | A | 0.0000 | |
| 141 | L | A | 0.0000 | |
| 142 | Q | A | 0.0000 | |
| 143 | E | A | 0.0000 | |
| 144 | Y | A | 0.0000 | |
| 145 | I | A | 0.0000 | |
| 146 | V | A | 0.0000 | |
| 147 | G | A | 0.0000 | |
| 148 | D | A | 0.0000 | |
| 149 | R | A | -0.6851 | |
| 150 | P | A | 0.0000 | |
| 151 | P | A | 0.0000 | |
| 152 | T | A | -0.4014 | |
| 153 | A | A | 0.0000 | |
| 154 | K | A | -0.3368 | |
| 155 | Y | A | -0.2237 | |
| 156 | T | A | -0.1770 | |
| 157 | A | A | 0.0000 | |
| 158 | K | A | -1.2077 | |
| 159 | A | A | -0.2191 | |
| 160 | A | A | -0.5590 | |
| 161 | P | A | -1.0843 | |
| 162 | D | A | -1.9937 | |
| 163 | P | A | -1.2438 | |
| 164 | G | A | -0.8369 | |
| 165 | L | A | -0.3726 | |
| 166 | P | A | -0.4817 | |
| 167 | P | A | -0.4960 | |
| 168 | G | A | -0.7991 | |
| 169 | A | A | -0.5500 | |
| 170 | T | A | -0.3179 | |
| 171 | P | A | -0.4426 | |
| 172 | P | A | 0.0630 | |
| 173 | L | A | 1.0388 | |
| 174 | T | A | 0.5327 | |
| 175 | T | A | 0.1068 | |
| 176 | V | A | 0.1765 | |
| 177 | T | A | -0.0335 | |
| 178 | T | A | -0.0379 | |
| 179 | T | A | -0.5451 | |
| 180 | I | A | 0.0000 | |
| 181 | E | A | -1.1440 | |
| 182 | H | A | -0.9979 | |
| 183 | G | A | -0.7299 | |
| 184 | D | A | -0.6358 | |
| 185 | M | A | 0.0000 | |
| 186 | A | A | 0.0000 | |
| 187 | D | A | -0.2687 | |
| 188 | I | A | 0.0000 | |
| 189 | G | A | -0.7987 | |
| 190 | F | A | -0.1461 | |
| 191 | G | A | -0.2649 | |
| 192 | A | A | -0.3981 | |
| 193 | K | A | -1.2310 | |
| 194 | D | A | -1.9669 | |
| 195 | F | A | 0.0000 | |
| 196 | K | A | -3.8763 | |
| 197 | E | A | -3.3426 | |
| 198 | L | A | -2.1482 | |
| 199 | E | A | -2.5037 | |
| 200 | P | A | -2.4325 | |
| 201 | R | A | -2.4505 | |
| 202 | K | A | -3.0392 | |
| 203 | N | A | -1.6813 | |
| 204 | D | A | 0.0000 | |
| 205 | V | A | 0.0000 | |
| 206 | P | A | 0.0000 | |
| 207 | L | A | -0.2319 | |
| 208 | D | A | 0.0000 | |
| 209 | I | A | 0.0000 | |
| 210 | L | A | -1.2618 | |
| 211 | N | A | -2.7664 | |
| 212 | T | A | -1.6512 | |
| 213 | T | A | -1.2084 | |
| 214 | T | A | 0.0000 | |
| 215 | K | A | 0.0000 | |
| 216 | V | A | 0.4162 | |
| 217 | P | A | 0.0000 | |
| 218 | D | A | 0.0000 | |
| 219 | Y | A | -1.3008 | |
| 220 | E | A | -2.4741 | |
| 221 | G | A | -1.8064 | |
| 222 | M | A | 0.0000 | |
| 223 | K | A | -2.9556 | |
| 224 | A | A | -1.6068 | |
| 225 | E | A | -1.3132 | |
| 226 | P | A | -0.8816 | |
| 227 | T | A | -0.5468 | |
| 228 | G | A | 0.0000 | |
| 229 | R | A | 0.0000 | |
| 230 | R | A | -0.9149 | |
| 231 | M | A | 0.0000 | |
| 232 | F | A | 0.0000 | |
| 233 | D | A | -1.2297 | |
| 234 | Y | A | -0.9958 | |
| 235 | D | A | -1.8220 | |
| 236 | R | A | -2.8153 | |
| 237 | K | A | -2.4842 | |
| 238 | E | A | -2.3274 | |
| 239 | S | A | -1.7825 | |
| 240 | S | A | -2.0789 | |
| 241 | K | A | -2.8658 | |
| 242 | D | A | -2.8804 | |
| 243 | I | A | -1.3969 | |
| 244 | K | A | -2.3921 | |
| 245 | K | A | -2.4499 | |
| 246 | L | A | 0.0000 | |
| 247 | R | A | 0.0000 | |
| 248 | R | A | -0.3291 | |
| 249 | S | A | -1.0517 | |
| 250 | G | A | -1.1908 | |
| 251 | P | A | -0.8472 | |
| 252 | E | A | -0.7824 | |
| 253 | K | A | -0.8321 | |
| 254 | F | A | 0.9820 | |
| 255 | P | A | -0.1480 | |
| 256 | L | A | 0.0180 | |
| 257 | P | A | -0.6412 | |
| 258 | D | A | -1.8344 | |
| 259 | A | A | -1.0550 | |
| 260 | P | A | -0.9822 | |
| 261 | P | A | -0.6071 | |
| 262 | P | A | -0.4258 | |
| 263 | S | A | -0.5400 | |
| 264 | K | A | -0.8856 | |
| 265 | L | A | 0.8949 | |
| 266 | Y | A | 1.0230 | |
| 267 | I | A | 1.3103 | |
| 268 | K | A | -0.3493 | |
| 269 | P | A | -0.0955 | |
| 270 | P | A | -0.3778 | |
| 271 | P | A | -0.5973 | |
| 272 | S | A | -0.2177 | |
| 273 | S | A | -0.2264 | |
| 274 | P | A | -0.3474 | |
| 275 | Y | A | 0.0182 | |
| 276 | Y | A | -0.6119 | |
| 277 | E | A | -2.2289 | |
| 278 | R | A | -1.6787 | |
| 279 | P | A | 0.0000 | |
| 280 | S | A | 0.0000 | |
| 281 | T | A | 0.0276 | |
| 282 | D | A | -0.1703 | |
| 283 | Y | A | 0.6888 | |
| 284 | F | A | -0.0194 | |
| 285 | T | A | -1.1269 | |
| 286 | I | A | 0.0000 | |
| 287 | P | A | 0.0000 | |
| 288 | D | A | -1.9522 | |
| 289 | E | A | -2.3114 | |
| 290 | G | A | -1.8506 | |
| 291 | E | A | -2.2186 | |
| 292 | I | A | -1.6788 | |
| 293 | T | A | -2.1343 | |
| 294 | E | A | -3.1758 | |
| 295 | E | A | -3.2718 | |
| 296 | D | A | -2.7008 | |
| 297 | L | A | 0.0000 | |
| 298 | L | A | 0.0000 | |
| 299 | F | A | 0.0000 | |
| 300 | N | A | -1.5003 | |
| 301 | K | A | -1.9029 | |
| 302 | P | A | -1.0834 | |
| 303 | K | A | -0.6595 | |
| 304 | F | A | -0.6582 | |
| 305 | F | A | 0.0000 | |
| 306 | D | A | -2.5531 | |
| 307 | K | A | -2.9927 | |
| 308 | T | A | 0.0000 | |
| 309 | E | A | -2.6779 | |
| 310 | G | A | -1.9303 | |
| 311 | L | A | -0.7505 | |
| 312 | N | A | 0.0000 | |
| 313 | N | A | 0.0000 | |
| 314 | G | A | 0.0000 | |
| 315 | V | A | 0.0000 | |
| 316 | L | A | 0.0000 | |
| 317 | W | A | 0.0000 | |
| 318 | H | A | -0.9847 | |
| 319 | N | A | -0.9598 | |
| 320 | R | A | -1.0252 | |
| 321 | L | A | 0.0000 | |
| 322 | Y | A | 0.0000 | |
| 323 | I | A | 0.0000 | |
| 324 | T | A | 0.0000 | |
| 325 | I | A | 0.0000 | |
| 326 | L | A | 0.0000 | |
| 327 | D | A | 0.0000 | |
| 328 | N | A | 0.0000 | |
| 329 | R | A | 0.0000 | |
| 330 | R | A | 0.0000 | |
| 331 | S | A | 0.0000 | |
| 332 | E | A | -2.1954 | |
| 333 | I | A | -0.8856 | |
| 334 | E | A | -0.7239 | |
| 335 | V | A | 0.9558 | |
| 336 | H | A | 0.3607 | |
| 337 | T | A | 0.4842 | |
| 338 | T | A | 0.0899 | |
| 339 | Q | A | -0.0138 | |
| 340 | L | A | 1.2795 | |
| 341 | S | A | 0.1504 | |
| 342 | T | A | -0.4767 | |
| 343 | P | A | -0.6336 | |
| 344 | E | A | -1.5510 | |
| 345 | P | A | -0.9533 | |
| 346 | N | A | -0.6266 | |
| 347 | V | A | 1.2173 | |
| 348 | F | A | 1.7127 | |
| 349 | N | A | 0.1514 | |
| 350 | P | A | 0.3750 | |
| 351 | A | A | 0.3280 | |
| 352 | N | A | 0.2686 | |
| 353 | Y | A | 0.8507 | |
| 354 | V | A | 1.1498 | |
| 355 | T | A | 0.7330 | |
| 356 | S | A | 0.5426 | |
| 357 | Y | A | 0.9129 | |
| 358 | S | A | 0.1256 | |
| 359 | Y | A | 0.0000 | |
| 360 | T | A | -0.6759 | |
| 361 | R | A | 0.0000 | |
| 362 | E | A | -0.1975 | |
| 363 | Y | A | 0.0000 | |
| 364 | K | A | -0.5376 | |
| 365 | I | A | 0.0000 | |
| 366 | S | A | 0.0000 | |
| 367 | L | A | 0.0000 | |
| 368 | I | A | 0.0000 | |
| 369 | V | A | 0.0000 | |
| 370 | Q | A | -0.4513 | |
| 371 | L | A | 0.0000 | |
| 372 | C | A | 0.0000 | |
| 373 | K | A | -0.8564 | |
| 374 | I | A | 0.0000 | |
| 375 | P | A | -0.8014 | |
| 376 | L | A | -0.6573 | |
| 377 | T | A | -0.8068 | |
| 378 | P | A | -1.3234 | |
| 379 | E | A | -2.0966 | |
| 380 | T | A | 0.0000 | |
| 381 | L | A | -1.1840 | |
| 382 | E | A | -2.2252 | |
| 383 | L | A | 0.0000 | |
| 384 | I | A | 0.0000 | |
| 385 | S | A | -1.0365 | |
| 386 | R | A | -1.4091 | |
| 387 | I | A | -0.6314 | |
| 388 | D | A | -0.6110 | |
| 389 | P | A | -0.8687 | |
| 390 | S | A | -0.7334 | |
| 391 | I | A | 0.0000 | |
| 392 | L | A | 0.0000 | |
| 393 | V | A | -0.8337 | |
| 394 | D | A | -2.0256 | |
| 395 | A | A | -1.5584 | |
| 396 | N | A | -1.5865 | |
| 397 | L | A | 0.0000 | |
| 398 | P | A | 0.4098 | |
| 399 | F | A | 1.7344 | |
| 400 | I | A | 0.8652 | |
| 401 | P | A | 0.3518 | |
| 402 | P | A | -0.2163 | |
| 403 | V | A | 0.3484 | |
| 404 | E | A | -1.6059 | |
| 405 | R | A | -1.6850 | |
| 406 | P | A | -1.3758 | |
| 407 | D | A | -1.6292 | |
| 408 | P | A | -0.9215 | |
| 409 | L | A | -0.8224 | |
| 410 | A | A | -0.9632 | |
| 411 | G | A | -1.2802 | |
| 412 | K | A | -1.8430 | |
| 413 | K | A | -2.4198 | |
| 414 | F | A | -1.3919 | |
| 415 | I | A | -1.1396 | |
| 416 | E | A | -2.2969 | |
| 417 | I | A | 0.0000 | |
| 418 | D | A | -2.6694 | |
| 419 | L | A | 0.0000 | |
| 420 | T | A | -1.6785 | |
| 421 | D | A | -2.3271 | |
| 422 | K | A | -1.8593 | |
| 423 | L | A | -0.7172 | |
| 424 | S | A | -0.8864 | |
| 425 | T | A | -0.9384 | |
| 426 | N | A | -2.4525 | |
| 427 | L | A | 0.0000 | |
| 428 | E | A | -3.6851 | |
| 429 | E | A | -3.3369 | |
| 430 | F | A | -2.0872 | |
| 431 | P | A | -1.6346 | |
| 432 | L | A | 0.0000 | |
| 433 | G | A | 0.0000 | |
| 434 | R | A | -3.3975 | |
| 435 | E | A | -2.3974 | |
| 436 | Y | A | -1.3080 | |
| 437 | L | A | -1.0176 | |
| 438 | N | A | -2.4055 | |
| 439 | R | A | -2.3470 |
ALA alanine
ARG arginine
ASN asparagine
ASP aspartic acid
CYS cysteine
GLN glutamine
GLU glutamic acid
GLY glycine
HIS histidine
ILE isoleucine
LEU leucine
LYS lysine
MET methionine
PHE phenylalanine
PRO proline
SER serine
THR threonine
TRP tryptophan
TYR tyrosine
VAL valine