Project name: 2f19dd5d5b652b8

Status: done

Started: 2026-05-01 00:37:17
Chain sequence(s) A: VYTHDTGLDYITYSDYELDPANPLAGGAAWIEGAFVPPSEARISIFDQGFYTSDATYTTFHVWNGNAFRLGDHIERLFSNAESIRLIPPLTQDEVKEIALELVAKTELREAMVTVTITRGYSSTPFERDITKHRPQVYMSAPYQWIVPFDRIRDGVHLMVAQSVRRTPRSSIDPQVKNFQWGDLIRAIQETHDRGFELPLLLDCDNLLAEGPGFNVVVIKDGVVRSPGRAALPGITRKTVLEIAESLGHEAILADITPAELYDADEVLGCSTGGGVWPFVSVDGNSISDGVPGPVTQSIIRRYWELNVEPSSLLTPVQY
B: PEIVYTHDTGLDYITYSDYELDPANPLAGGAAWIEGAFVPPSEARISIFDQGFYTSDATYTTFHVWNGNAFRLGDHIERLFSNAESIRLIPPLTQDEVKEIALELVAKTELREAMVTVTITRGYSSTPFERDITKHRPQVYMSAPYQWIVPFDRIRDGVHLMVAQSVRRTPRSSIDPQVKNFQWGDLIRAIQETHDRGFELPLLLDCDNLLAEGPGFNVVVIKDGVVRSPGRAALPGITRKTVLEIAESLGHEAILADITPAELYDADEVLGCSTGGGVWPFVSVDGNSISDGVPGPVTQSIIRRYWELNVEPSSLLTPVQY
input PDB
Selected Chain(s) A,B
Distance of aggregation 10 Å
FoldX usage Yes
pH calculations No
alphaCutter usage No
Dynamic mode No
Automated mutations Yes
Downloads Download all the data
Simulation log 
[INFO]       Logger:   Verbosity set to: 2 - [INFO]                                                (00:00:02)
[WARNING]    runJob:   Working directory already exists (possibly overwriting previous results -ow 
                       to prevent this behavior)                                                   (00:00:02)
[INFO]       runJob:   Starting aggrescan3d job on: input.pdb with all chain(s) selected           (00:00:02)
[INFO]       runJob:   Creating pdb object from: input.pdb                                         (00:00:02)
[INFO]       FoldX:    Starting FoldX energy minimization                                          (00:00:02)
[INFO]       Analysis: Starting Aggrescan4D on folded.pdb                                          (00:06:58)
[INFO]       AutoMutEv:Residue number 11 from chain B and a score of 1.951 (valine) selected for   
                       automated mutation                                                          (00:07:03)
[INFO]       AutoMutEv:Residue number 11 from chain A and a score of 1.708 (valine) selected for   
                       automated mutation                                                          (00:07:03)
[INFO]       AutoMutEv:Residue number 10 from chain B and a score of 1.332 (isoleucine) selected   
                       for automated mutation                                                      (00:07:03)
[INFO]       AutoMutEv:Residue number 97 from chain B and a score of 1.311 (isoleucine) selected   
                       for automated mutation                                                      (00:07:03)
[INFO]       AutoMutEv:Residue number 97 from chain A and a score of 1.259 (isoleucine) selected   
                       for automated mutation                                                      (00:07:03)
[INFO]       AutoMutEv:Residue number 264 from chain A and a score of 1.027 (leucine) selected for 
                       automated mutation                                                          (00:07:03)
[INFO]       AutoMutEv:Mutating residue number 11 from chain B (valine) into threonine             (00:07:03)
[INFO]       AutoMutEv:Mutating residue number 11 from chain B (valine) into methionine            (00:07:03)
[INFO]       AutoMutEv:Mutating residue number 11 from chain A (valine) into alanine               (00:07:03)
[INFO]       AutoMutEv:Mutating residue number 11 from chain B (valine) into alanine               (00:07:16)
[INFO]       AutoMutEv:Mutating residue number 11 from chain A (valine) into threonine             (00:07:17)
[INFO]       AutoMutEv:Mutating residue number 11 from chain A (valine) into methionine            (00:07:17)
[INFO]       AutoMutEv:Mutating residue number 10 from chain B (isoleucine) into threonine         (00:07:29)
[INFO]       AutoMutEv:Mutating residue number 10 from chain B (isoleucine) into leucine           (00:07:29)
[INFO]       AutoMutEv:Mutating residue number 97 from chain B (isoleucine) into methionine        (00:07:33)
[INFO]       AutoMutEv:Mutating residue number 10 from chain B (isoleucine) into methionine        (00:07:42)
[INFO]       AutoMutEv:Mutating residue number 97 from chain B (isoleucine) into threonine         (00:07:43)
[INFO]       AutoMutEv:Mutating residue number 97 from chain B (isoleucine) into leucine           (00:07:51)
[INFO]       AutoMutEv:Mutating residue number 97 from chain A (isoleucine) into threonine         (00:07:56)
[INFO]       AutoMutEv:Mutating residue number 97 from chain A (isoleucine) into leucine           (00:07:57)
[INFO]       AutoMutEv:Mutating residue number 97 from chain A (isoleucine) into methionine        (00:08:09)
[INFO]       AutoMutEv:Mutating residue number 264 from chain A (leucine) into methionine          (00:08:11)
[INFO]       AutoMutEv:Effect of mutation residue number 11 from chain B (valine) into threonine:  
                       Energy difference: -0.0827 kcal/mol, Difference in average score from the   
                       base case: -0.0082                                                          (00:08:27)
[INFO]       AutoMutEv:Effect of mutation residue number 11 from chain B (valine) into alanine:    
                       Energy difference: 0.1676 kcal/mol, Difference in average score from the    
                       base case: -0.0079                                                          (00:08:27)
[INFO]       AutoMutEv:Effect of mutation residue number 11 from chain B (valine) into methionine: 
                       Energy difference: 0.0113 kcal/mol, Difference in average score from the    
                       base case: -0.0032                                                          (00:08:27)
[INFO]       AutoMutEv:Effect of mutation residue number 11 from chain A (valine) into threonine:  
                       Energy difference: 0.0295 kcal/mol, Difference in average score from the    
                       base case: -0.0066                                                          (00:08:27)
[INFO]       AutoMutEv:Effect of mutation residue number 11 from chain A (valine) into alanine:    
                       Energy difference: -0.0828 kcal/mol, Difference in average score from the   
                       base case: -0.0056                                                          (00:08:27)
[INFO]       AutoMutEv:Effect of mutation residue number 11 from chain A (valine) into methionine: 
                       Energy difference: -0.0926 kcal/mol, Difference in average score from the   
                       base case: -0.0013                                                          (00:08:27)
[INFO]       AutoMutEv:Effect of mutation residue number 10 from chain B (isoleucine) into         
                       threonine: Energy difference: 1.0301 kcal/mol, Difference in average score  
                       from the base case: -0.0085                                                 (00:08:27)
[INFO]       AutoMutEv:Effect of mutation residue number 10 from chain B (isoleucine) into         
                       methionine: Energy difference: 0.6430 kcal/mol, Difference in average score 
                       from the base case: -0.0036                                                 (00:08:27)
[INFO]       AutoMutEv:Effect of mutation residue number 10 from chain B (isoleucine) into         
                       leucine: Energy difference: -0.6976 kcal/mol, Difference in average score   
                       from the base case: -0.0032                                                 (00:08:27)
[INFO]       AutoMutEv:Effect of mutation residue number 97 from chain B (isoleucine) into         
                       threonine: Energy difference: 0.2954 kcal/mol, Difference in average score  
                       from the base case: -0.0085                                                 (00:08:27)
[INFO]       AutoMutEv:Effect of mutation residue number 97 from chain B (isoleucine) into         
                       methionine: Energy difference: -0.0863 kcal/mol, Difference in average      
                       score from the base case: -0.0058                                           (00:08:27)
[INFO]       AutoMutEv:Effect of mutation residue number 97 from chain B (isoleucine) into         
                       leucine: Energy difference: 0.0404 kcal/mol, Difference in average score    
                       from the base case: -0.0034                                                 (00:08:27)
[INFO]       AutoMutEv:Effect of mutation residue number 97 from chain A (isoleucine) into         
                       threonine: Energy difference: 0.1643 kcal/mol, Difference in average score  
                       from the base case: -0.0084                                                 (00:08:27)
[INFO]       AutoMutEv:Effect of mutation residue number 97 from chain A (isoleucine) into         
                       methionine: Energy difference: -0.1296 kcal/mol, Difference in average      
                       score from the base case: -0.0049                                           (00:08:27)
[INFO]       AutoMutEv:Effect of mutation residue number 97 from chain A (isoleucine) into         
                       leucine: Energy difference: -0.0602 kcal/mol, Difference in average score   
                       from the base case: 0.0001                                                  (00:08:27)
[INFO]       AutoMutEv:Effect of mutation residue number 264 from chain A (leucine) into           
                       methionine: Energy difference: 0.2268 kcal/mol, Difference in average score 
                       from the base case: -0.0021                                                 (00:08:27)
[INFO]       Main:     Simulation completed successfully.                                          (00:08:35)
Show buried residues
Minimal score value
-3.4144
Maximal score value
1.9511
Average score
-0.6102
Total score value
-391.1347
Download the table (csv)

The table below lists A4D score for protein residues. Residues with A4D score > 0.0000 are marked by yellow rows.

residue index residue name chain Aggrescan4D score mutation
11 V A 1.7081
12 Y A 0.4386
13 T A -0.6785
14 H A -1.2785
15 D A -2.4001
16 T A -1.7810
17 G A -1.8508
18 L A -1.7298
19 D A -1.9748
20 Y A -0.8965
21 I A 0.0000
22 T A -1.0668
23 Y A 0.0000
24 S A -1.4168
25 D A -2.1850
26 Y A -1.7204
27 E A -2.3338
28 L A -1.4672
29 D A -1.8592
30 P A -1.1779
31 A A -0.6451
32 N A -0.9987
33 P A -0.7237
34 L A 0.0000
35 A A -1.0155
36 G A -0.5189
37 G A -0.3098
38 A A 0.0000
39 A A 0.0000
40 W A -0.0941
41 I A 0.0000
42 E A -1.1690
43 G A -0.7564
44 A A -0.1949
45 F A -0.0885
46 V A -0.3240
47 P A -0.6208
48 P A -0.7289
49 S A -1.1371
50 E A -2.0515
51 A A 0.0000
52 R A -1.2564
53 I A 0.0000
54 S A 0.0000
55 I A 0.0000
56 F A 0.8040
57 D A 0.0000
58 Q A 0.0000
59 G A 0.0000
60 F A 0.0000
61 Y A 0.4952
62 T A 0.0000
63 S A 0.0000
64 D A 0.0000
65 A A 0.0000
66 T A 0.0000
67 Y A 0.0000
68 T A 0.0000
69 T A -0.0370
70 F A 0.0000
71 H A 0.0000
72 V A 0.0000
73 W A 0.0000
74 N A -0.7341
75 G A -0.5621
76 N A -0.4363
77 A A 0.0000
78 F A 0.0000
79 R A -0.4739
80 L A 0.0000
81 G A -1.6441
82 D A -1.6901
83 H A 0.0000
84 I A 0.0000
85 E A -2.2710
86 R A 0.0000
87 L A 0.0000
88 F A 0.0000
89 S A -1.2943
90 N A 0.0000
91 A A 0.0000
92 E A -1.6742
93 S A -1.0187
94 I A -0.6130
95 R A -0.8590
96 L A 0.0000
97 I A 1.2591
98 P A 0.2493
99 P A -0.0940
100 L A -0.3336
101 T A -1.1646
102 Q A -2.4097
103 D A -3.1551
104 E A -2.7396
105 V A 0.0000
106 K A -2.5875
107 E A -3.1302
108 I A -1.6648
109 A A 0.0000
110 L A -1.4360
111 E A -1.8874
112 L A 0.0000
113 V A 0.0000
114 A A -0.8839
115 K A -1.1581
116 T A 0.0000
117 E A -1.1410
118 L A 0.0000
119 R A -0.8193
120 E A 0.0000
121 A A 0.0000
122 M A -0.2529
123 V A 0.0000
124 T A -0.0057
125 V A 0.0000
126 T A 0.0000
127 I A 0.0000
128 T A 0.0000
129 R A 0.0000
130 G A 0.0000
131 Y A 0.4215
132 S A -0.5419
133 S A 0.0000
134 T A -0.1901
135 P A -0.1639
136 F A -0.4547
137 E A -1.7185
138 R A -2.8091
139 D A -2.4353
140 I A -0.5780
141 T A -1.1210
142 K A -2.1663
143 H A -1.4528
144 R A -1.7007
145 P A -0.6625
146 Q A -0.5229
147 V A 0.0000
148 Y A 0.0000
149 M A 0.0000
150 S A 0.1428
151 A A -0.0936
153 P A -0.0572
154 Y A 0.0000
155 Q A -1.0480
156 W A -0.2847
157 I A 0.1558
158 V A 0.0000
159 P A -1.1959
160 F A -1.8276
161 D A -3.1160
162 R A -2.6727
163 I A 0.0000
164 R A -3.4144
165 D A -2.9335
166 G A 0.0000
167 V A 0.0000
168 H A -1.1058
169 L A 0.0000
170 M A 0.0000
171 V A 0.0000
172 A A 0.0000
173 Q A -1.3911
174 S A -1.0208
175 V A 0.0000
176 R A -1.0718
177 R A 0.0000
178 T A 0.0000
179 P A -0.8394
180 R A -1.4549
181 S A -1.0499
182 S A 0.0000
183 I A 0.0000
184 D A -0.8884
185 P A 0.0000
186 Q A -0.5886
187 V A -0.4264
188 K A -0.2357
189 N A 0.0000
190 F A 0.0000
191 Q A 0.0000
192 W A 0.0803
193 G A -0.0831
194 D A 0.0000
195 L A 0.0000
196 I A 0.0273
197 R A -0.7633
198 A A 0.0000
199 I A 0.0000
200 Q A -1.5426
201 E A 0.0000
202 T A 0.0000
203 H A -2.8785
204 D A -2.8180
205 R A -2.3092
206 G A -1.8708
207 F A -1.2888
208 E A -1.1472
209 L A 0.0000
210 P A 0.0000
211 L A 0.0000
212 L A 0.0000
213 L A 0.0000
214 D A 0.0000
215 C A -0.4782
216 D A -2.0909
217 N A -1.8083
218 L A -1.3320
219 L A 0.0000
220 A A 0.0000
221 E A 0.0000
222 G A 0.0000
223 P A 0.0000
224 G A -0.1979
225 F A 0.0000
226 N A 0.0000
227 V A 0.0000
228 V A 0.0000
229 V A 0.0000
230 I A 0.0000
231 K A -2.5724
232 D A -2.4638
233 G A -1.7868
234 V A -1.4020
235 V A 0.0000
236 R A -0.0673
237 S A 0.0000
238 P A 0.0000
239 G A -0.3693
240 R A -1.0974
241 A A 0.0000
242 A A 0.0000
243 L A -0.1531
244 P A -0.2321
245 G A 0.0000
246 I A 0.0000
247 T A 0.0000
248 R A 0.0000
249 K A -1.2525
250 T A 0.0000
251 V A 0.0000
252 L A -1.2090
253 E A -2.2764
254 I A 0.0000
255 A A 0.0000
256 E A -2.7038
257 S A -1.5401
258 L A -0.8535
259 G A -1.5258
260 H A -1.9137
261 E A -2.2126
262 A A -0.9885
263 I A 0.7691
264 L A 1.0273
265 A A -0.1805
266 D A -1.7795
267 I A 0.0000
268 T A -1.1475
269 P A -0.5737
270 A A -0.6515
271 E A -1.5004
272 L A 0.0000
273 Y A -1.1575
274 D A -2.4199
275 A A 0.0000
276 D A -2.4936
277 E A 0.0000
278 V A 0.0000
279 L A 0.0000
280 G A 0.0000
281 C A 0.0000
282 S A -0.0387
283 T A -0.1708
284 G A -0.3310
285 G A 0.0000
286 G A 0.0000
287 V A 0.0000
288 W A 0.0000
289 P A 0.0000
290 F A 0.0000
291 V A 0.0000
292 S A 0.0000
293 V A 0.0000
294 D A -1.2506
295 G A -1.4235
296 N A -2.0830
297 S A -1.5973
298 I A 0.0000
299 S A -1.5976
300 D A -1.7442
301 G A -0.8851
302 V A 0.4222
303 P A -0.6672
304 G A -0.4323
305 P A -0.3468
306 V A -0.3316
307 T A 0.0000
308 Q A -1.5865
309 S A -0.8379
310 I A 0.0000
311 I A 0.0000
312 R A -1.4607
313 R A -1.1806
314 Y A 0.0000
315 W A 0.0000
316 E A -0.8838
317 L A -0.3063
318 N A 0.0000
319 V A 0.1662
320 E A -1.3814
321 P A -0.9056
322 S A -0.5036
323 S A -0.4437
324 L A -0.1125
325 L A -0.1223
326 T A -0.3691
327 P A -0.5528
328 V A 0.0000
329 Q A -1.1450
330 Y A -0.1545
8 P B -0.6021
9 E B -0.8395
10 I B 1.3320
11 V B 1.9511
12 Y B 0.6336
13 T B -0.5013
14 H B -1.2077
15 D B -2.3536
16 T B -1.7475
17 G B -1.8677
18 L B -1.7612
19 D B -2.0306
20 Y B -1.1805
21 I B 0.0000
22 T B -1.0360
23 Y B 0.0000
24 S B -1.3760
25 D B -2.1737
26 Y B -1.8132
27 E B -2.5712
28 L B 0.0000
29 D B -2.5059
30 P B -1.4834
31 A B -0.8478
32 N B -1.1981
33 P B -0.7828
34 L B 0.0000
35 A B -1.0078
36 G B 0.0000
37 G B 0.0000
38 A B 0.0000
39 A B 0.0000
40 W B -0.0997
41 I B 0.0000
42 E B -1.0027
43 G B -0.6787
44 A B -0.1482
45 F B -0.0806
46 V B -0.3142
47 P B -0.6825
48 P B -0.7307
49 S B -1.1217
50 E B -2.0388
51 A B 0.0000
52 R B -1.2160
53 I B 0.0000
54 S B -0.2954
55 I B 0.0000
56 F B 0.8349
57 D B 0.0000
58 Q B 0.0000
59 G B 0.0000
60 F B 0.0000
61 Y B 0.5357
62 T B 0.0000
63 S B 0.0000
64 D B 0.0000
65 A B 0.0000
66 T B 0.0000
67 Y B 0.0000
68 T B 0.0000
69 T B -0.0332
70 F B 0.0000
71 H B 0.0000
72 V B 0.0000
73 W B 0.0000
74 N B -0.6701
75 G B -0.5248
76 N B -0.4220
77 A B 0.0000
78 F B 0.0000
79 R B 0.0000
80 L B 0.0000
81 G B -1.6414
82 D B -1.6973
83 H B 0.0000
84 I B 0.0000
85 E B -2.1787
86 R B 0.0000
87 L B 0.0000
88 F B -0.8349
89 S B -1.1644
90 N B 0.0000
91 A B 0.0000
92 E B -1.6388
93 S B -1.1851
94 I B -0.6079
95 R B -0.9242
96 L B 0.0000
97 I B 1.3109
98 P B 0.2555
99 P B -0.1440
100 L B -0.4325
101 T B -1.1958
102 Q B -2.3974
103 D B -3.2208
104 E B -2.8475
105 V B 0.0000
106 K B -2.5885
107 E B -3.1496
108 I B -1.6747
109 A B 0.0000
110 L B -1.4289
111 E B -1.8542
112 L B 0.0000
113 V B 0.0000
114 A B -0.8340
115 K B -1.0639
116 T B 0.0000
117 E B -1.2213
118 L B 0.0000
119 R B -0.7618
120 E B 0.0000
121 A B 0.0000
122 M B -0.2127
123 V B 0.0000
124 T B -0.0012
125 V B 0.0000
126 T B 0.0000
127 I B 0.0000
128 T B 0.0000
129 R B 0.0000
130 G B 0.0000
131 Y B 0.4780
132 S B -0.5664
133 S B 0.0000
134 T B -0.0990
135 P B -0.0547
136 F B -0.2713
137 E B -1.2954
138 R B -2.3907
139 D B -1.8780
140 I B -0.2560
141 T B -0.9713
142 K B -2.0520
143 H B 0.0000
144 R B -1.7153
145 P B -0.6828
146 Q B -0.5216
147 V B 0.0000
148 Y B 0.0000
149 M B 0.0000
150 S B 0.1439
151 A B -0.0774
153 P B 0.2254
154 Y B 0.0000
155 Q B -1.0484
156 W B -0.2929
157 I B 0.1059
158 V B 0.0000
159 P B -1.0888
160 F B -1.7275
161 D B -2.9063
162 R B -2.4149
163 I B 0.0000
164 R B -3.1454
165 D B -2.3369
166 G B 0.0000
167 V B 0.0000
168 H B -1.0348
169 L B 0.0000
170 M B 0.0000
171 V B 0.0000
172 A B 0.0000
173 Q B -1.4287
174 S B -1.0593
175 V B 0.0000
176 R B -1.2871
177 R B 0.0000
178 T B 0.0000
179 P B -1.0235
180 R B -1.5683
181 S B -1.0045
182 S B 0.0000
183 I B 0.0000
184 D B -1.0316
185 P B 0.0000
186 Q B -0.8025
187 V B -0.4499
188 K B -0.2925
189 N B -0.1876
190 F B 0.0000
191 Q B 0.0000
192 W B 0.0043
193 G B -0.1499
194 D B 0.0000
195 L B 0.0000
196 I B 0.0000
197 R B -0.7968
198 A B 0.0000
199 I B -0.7078
200 Q B -1.4439
201 E B 0.0000
202 T B 0.0000
203 H B -2.8621
204 D B -2.7239
205 R B -2.1771
206 G B -1.7383
207 F B -1.1265
208 E B -0.9135
209 L B 0.0000
210 P B 0.0000
211 L B 0.0000
212 L B 0.0000
213 L B 0.0000
214 D B -1.1744
215 C B -0.6184
216 D B -1.9469
217 N B -1.5309
218 L B -1.2300
219 L B 0.0000
220 A B 0.0000
221 E B 0.0000
222 G B 0.0000
223 P B 0.0000
224 G B -0.1666
225 F B 0.0000
226 N B 0.0000
227 V B 0.0000
228 V B 0.0000
229 V B 0.0000
230 I B 0.0000
231 K B -2.2825
232 D B -2.5174
233 G B -1.6633
234 V B -1.4223
235 V B 0.0000
236 R B -0.1065
237 S B 0.0000
238 P B 0.0000
239 G B -0.6984
240 R B -2.1062
241 A B 0.0000
242 A B 0.0000
243 L B -0.3470
244 P B -0.3605
245 G B 0.0000
246 I B 0.0000
247 T B 0.0000
248 R B 0.0000
249 K B -1.1581
250 T B 0.0000
251 V B 0.0000
252 L B -1.3169
253 E B -2.3468
254 I B 0.0000
255 A B 0.0000
256 E B -2.7535
257 S B -1.5371
258 L B -0.7412
259 G B -1.3470
260 H B -1.9972
261 E B -2.4938
262 A B -1.1512
263 I B 0.3347
264 L B 0.8855
265 A B -0.0618
266 D B -1.2897
267 I B 0.0000
268 T B -0.8597
269 P B -0.4593
270 A B -0.5699
271 E B -1.4038
272 L B 0.0000
273 Y B -1.0599
274 D B -2.3092
275 A B 0.0000
276 D B -2.3783
277 E B 0.0000
278 V B 0.0000
279 L B 0.0000
280 G B 0.0000
281 C B 0.0000
282 S B -0.0374
283 T B -0.1636
284 G B -0.3205
285 G B 0.0000
286 G B 0.0000
287 V B 0.0000
288 W B 0.0000
289 P B 0.0000
290 F B 0.0000
291 V B 0.0000
292 S B 0.0000
293 V B 0.0000
294 D B -1.2523
295 G B -1.4306
296 N B -2.1030
297 S B -1.5069
298 I B 0.0000
299 S B -1.5962
300 D B -1.7643
301 G B -0.8413
302 V B 0.5408
303 P B -0.5811
304 G B -0.4459
305 P B -0.4798
306 V B -0.3427
307 T B 0.0000
308 Q B -1.8022
309 S B -1.0706
310 I B 0.0000
311 I B 0.0000
312 R B -2.0992
313 R B -1.8750
314 Y B 0.0000
315 W B 0.0000
316 E B -1.8014
317 L B -0.9273
318 N B 0.0000
319 V B -0.0729
320 E B -1.6092
321 P B -0.9876
322 S B -0.4734
323 S B -0.3767
324 L B -0.0654
325 L B -0.0832
326 T B -0.3346
327 P B -0.5572
328 V B 0.0000
329 Q B -1.1219
330 Y B -0.0584
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Automated mutations analysis - evolutionary conserved mutations

In the automated mutations mode, the server selects aggregation prone resides and each selected residue is mutated based off an evolutionary approach. The table below shows 2 best scored mutants for each mutated residue. Protein variants are ordered according to the mutation effect they had on protein stability (energetic effect) together with the difference in the average per-residue aggregation score between the wild type and the mutant (in the table green values indicate a positive change, grey are neutral, and orange/red mean destabilizing or more aggregation prone mutants).
Summary for all the mutants can be found in this CSV file .

Mutant
Energetic effect
Score comparison
VT11B -0.0827 -0.0082 View CSV PDB
IL10B -0.6976 -0.0032 View CSV PDB
IM97B -0.0863 -0.0058 View CSV PDB
VA11A -0.0828 -0.0056 View CSV PDB
IM97A -0.1296 -0.0049 View CSV PDB
VM11A -0.0926 -0.0013 View CSV PDB
VM11B 0.0113 -0.0032 View CSV PDB
IL97B 0.0404 -0.0034 View CSV PDB
IT97A 0.1643 -0.0084 View CSV PDB
LM264A 0.2268 -0.0021 View CSV PDB
IT10B 1.0301 -0.0085 View CSV PDB