Project name: S149T

Status: done

Started: 2026-08-16 07:23:22
Chain sequence(s) A: QCIQPGTGYNNGYFYSYWNDGHGGVTYCNGPGGQFSVNWSNSGNFVGGKGWQPGTKNKVINFSGSYNPNGNSYLSVYGWSRNPLIEYYIVENFGTYNPSTGATKLGEVTSDGSVYDIYRTQRVNQPSIIGTATFYQYWSVRRNHRSSGTVNTANHFNAWAQQGLTLGTMDYQIVAVEGYFSSGSASITVS
input PDB
Selected Chain(s) A
Distance of aggregation 10 Å
FoldX usage Yes
pH calculations No
alphaCutter usage No
Dynamic mode No
Automated mutations No
Downloads Download all the data
Simulation log 
[INFO]       Logger:   Verbosity set to: 2 - [INFO]                                                (00:00:02)
[WARNING]    runJob:   Working directory already exists (possibly overwriting previous results -ow 
                       to prevent this behavior)                                                   (00:00:02)
[INFO]       runJob:   Starting aggrescan3d job on: input.pdb with A chain(s) selected             (00:00:02)
[INFO]       runJob:   Creating pdb object from: input.pdb                                         (00:00:02)
[INFO]       FoldX:    Starting FoldX energy minimization                                          (00:00:02)
[INFO]       Analysis: Starting Aggrescan4D on folded.pdb                                          (00:02:22)
[INFO]       Main:     Simulation completed successfully.                                          (00:02:24)
Show buried residues
Minimal score value
-2.414
Maximal score value
1.9593
Average score
-0.4774
Total score value
-90.7083
Download the table (csv)

The table below lists A4D score for protein residues. Residues with A4D score > 0.0000 are marked by yellow rows.

residue index residue name chain Aggrescan4D score mutation
1 Q A -0.7469
2 C A 0.1861
3 I A -0.0628
4 Q A -0.8395
5 P A -0.7446
6 G A -0.4484
7 T A 0.0287
8 G A 0.4507
9 Y A 0.8540
10 N A -0.4711
11 N A -1.4179
12 G A -0.7504
13 Y A -0.1997
14 F A 0.0000
15 Y A 0.2565
16 S A 0.0000
17 Y A 0.0000
18 W A -0.2257
19 N A -1.1152
20 D A -1.7382
21 G A -1.6753
22 H A -1.7757
23 G A -1.5273
24 G A -1.2069
25 V A -1.0504
26 T A -0.4423
27 Y A 0.0000
28 C A -0.2013
29 N A 0.0000
30 G A -0.8156
31 P A -1.0729
32 G A -1.1209
33 G A 0.0000
34 Q A -0.8314
35 F A 0.0000
36 S A -0.5226
37 V A 0.0000
38 N A -1.5382
39 W A 0.0000
40 S A -1.1702
41 N A -1.1559
42 S A 0.0000
43 G A 0.0000
44 N A -0.2307
45 F A 0.0000
46 V A 0.1358
47 G A 0.0000
48 G A 0.0000
49 K A 0.0000
50 G A 0.0000
51 W A 0.0279
52 Q A -0.2972
53 P A -0.4824
54 G A 0.0000
55 T A -1.0870
56 K A -1.9245
57 N A -2.0822
58 K A -1.0905
59 V A -0.1657
60 I A 0.0000
61 N A -0.7895
62 F A 0.0000
63 S A -0.7004
64 G A -0.5852
65 S A -0.7345
66 Y A -0.9296
67 N A -1.7823
68 P A -1.6096
69 N A -1.7403
70 G A -0.6302
71 N A 0.0831
72 S A 0.0000
73 Y A 0.0000
74 L A 0.0000
75 S A 0.0000
76 V A 0.0000
77 Y A 0.0000
78 G A 0.0000
79 W A 0.0000
80 S A 0.0000
81 R A -0.9609
82 N A -1.6355
83 P A -0.9917
84 L A -0.1667
85 I A 0.0000
86 E A 0.0000
87 Y A 0.0000
88 Y A 0.0000
89 I A 0.0000
90 V A 0.0000
91 E A 0.0000
92 N A -0.9192
93 F A -0.4044
94 G A -0.7007
95 T A -0.2918
96 Y A 0.2844
97 N A -0.3088
98 P A -0.1911
99 S A 0.0000
100 T A -0.5373
101 G A -0.8712
102 A A -0.9701
103 T A -1.1997
104 K A -2.0408
105 L A -1.1463
106 G A -1.4674
107 E A -1.8886
108 V A -0.8198
109 T A -0.4395
110 S A 0.0000
111 D A -0.8712
112 G A -0.8461
113 S A 0.0000
114 V A -0.6779
115 Y A 0.0000
116 D A 0.0000
117 I A 0.0000
118 Y A 0.0000
119 R A -1.1264
120 T A -0.8389
121 Q A -0.7778
122 R A -0.6766
123 V A 0.4044
124 N A -1.1153
125 Q A -1.2016
126 P A -0.4296
127 S A 0.2235
128 I A 1.2157
129 I A 1.9593
130 G A 0.4007
131 T A -0.2737
132 A A -0.0789
133 T A -0.2764
134 F A 0.0000
135 Y A 0.0314
136 Q A 0.0000
137 Y A 0.0000
138 W A 0.0000
139 S A 0.0000
140 V A 0.0000
141 R A 0.0000
142 R A -2.2005
143 N A -2.4140
144 H A -1.9598
145 R A -1.2816
146 S A -0.7244
147 S A -0.6854
148 G A -0.6727
149 T A -0.5045
150 V A 0.0000
151 N A -0.8324
152 T A 0.0000
153 A A 0.0000
154 N A -1.2972
155 H A 0.0000
156 F A 0.0000
157 N A -2.1100
158 A A -1.6498
159 W A 0.0000
160 A A -1.3704
161 Q A -1.9845
162 Q A -1.7190
163 G A -1.2282
164 L A 0.0000
165 T A -0.7214
166 L A -0.5715
167 G A -0.8465
168 T A -0.7781
169 M A 0.0000
170 D A 0.0000
171 Y A 0.0000
172 Q A 0.0000
173 I A 0.0000
174 V A 0.0000
175 A A 0.0000
176 V A 0.0000
177 E A 0.0459
178 G A 0.0000
179 Y A 1.3342
180 F A 1.5035
181 S A 0.0000
182 S A -1.0674
183 G A -1.5909
184 S A -1.3083
185 A A 0.0000
186 S A -0.6718
187 I A 0.0000
188 T A -0.6451
189 V A 0.0000
190 S A -0.4277
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