Project name: Q121T

Status: done

Started: 2026-08-16 07:18:26
Chain sequence(s) A: QCIQPGTGYNNGYFYSYWNDGHGGVTYCNGPGGQFSVNWSNSGNFVGGKGWQPGTKNKVINFSGSYNPNGNSYLSVYGWSRNPLIEYYIVENFGTYNPSTGATKLGEVTSDGSVYDIYRTTRVNQPSIIGTATFYQYWSVRRNHRSSGSVNTANHFNAWAQQGLTLGTMDYQIVAVEGYFSSGSASITVS
input PDB
Selected Chain(s) A
Distance of aggregation 10 Å
FoldX usage Yes
pH calculations No
alphaCutter usage No
Dynamic mode No
Automated mutations No
Downloads Download all the data
Simulation log 
[INFO]       Logger:   Verbosity set to: 2 - [INFO]                                                (00:00:02)
[WARNING]    runJob:   Working directory already exists (possibly overwriting previous results -ow 
                       to prevent this behavior)                                                   (00:00:02)
[INFO]       runJob:   Starting aggrescan3d job on: input.pdb with A chain(s) selected             (00:00:02)
[INFO]       runJob:   Creating pdb object from: input.pdb                                         (00:00:02)
[INFO]       FoldX:    Starting FoldX energy minimization                                          (00:00:02)
[INFO]       Analysis: Starting Aggrescan4D on folded.pdb                                          (00:02:06)
[INFO]       Main:     Simulation completed successfully.                                          (00:02:08)
Show buried residues
Minimal score value
-2.6061
Maximal score value
1.957
Average score
-0.4691
Total score value
-89.1212
Download the table (csv)

The table below lists A4D score for protein residues. Residues with A4D score > 0.0000 are marked by yellow rows.

residue index residue name chain Aggrescan4D score mutation
1 Q A -0.7524
2 C A 0.1938
3 I A -0.0437
4 Q A -0.8258
5 P A -0.6877
6 G A -0.4448
7 T A 0.0246
8 G A 0.4394
9 Y A 0.8406
10 N A -0.4804
11 N A -1.4061
12 G A -0.7355
13 Y A -0.1983
14 F A 0.0000
15 Y A 0.2427
16 S A 0.2292
17 Y A 0.0000
18 W A -0.0907
19 N A -0.8784
20 D A -1.3246
21 G A -1.4764
22 H A -1.6476
23 G A -1.4525
24 G A -1.1971
25 V A -1.0338
26 T A -0.4342
27 Y A 0.0000
28 C A -0.2114
29 N A 0.0000
30 G A -0.8579
31 P A -1.0687
32 G A -1.0682
33 G A 0.0000
34 Q A -0.8768
35 F A 0.0000
36 S A -0.5410
37 V A 0.0000
38 N A -1.5373
39 W A 0.0000
40 S A -1.1687
41 N A -1.1433
42 S A 0.0000
43 G A 0.0000
44 N A -0.0086
45 F A 0.0000
46 V A 0.2412
47 G A 0.0000
48 G A 0.0000
49 K A 0.0000
50 G A 0.0000
51 W A 0.0174
52 Q A -0.3166
53 P A -0.4982
54 G A -0.7150
55 T A -0.9387
56 K A -1.8475
57 N A -1.8191
58 K A -0.5133
59 V A 0.7260
60 I A 0.0000
61 N A -0.8434
62 F A 0.0000
63 S A -0.7149
64 G A -0.5581
65 S A -0.7165
66 Y A -0.9039
67 N A -1.7711
68 P A -1.5871
69 N A -1.7400
70 G A -0.6064
71 N A 0.1359
72 S A 0.0000
73 Y A 0.0545
74 L A 0.0000
75 S A 0.0000
76 V A 0.0000
77 Y A 0.0000
78 G A 0.0000
79 W A 0.0000
80 S A 0.0000
81 R A -0.9228
82 N A -1.6096
83 P A -0.9470
84 L A -0.1134
85 I A 0.0000
86 E A 0.0000
87 Y A 0.0000
88 Y A 0.0000
89 I A 0.0000
90 V A 0.0000
91 E A 0.0000
92 N A -0.8888
93 F A -0.3383
94 G A -0.6578
95 T A -0.2737
96 Y A 0.3161
97 N A -0.2976
98 P A -0.1724
99 S A 0.0000
100 T A -0.5000
101 G A -0.8341
102 A A -0.8165
103 T A -1.0107
104 K A -1.8620
105 L A -1.0387
106 G A -1.4445
107 E A -1.9614
108 V A -0.9167
109 T A -0.5394
110 S A 0.0000
111 D A -0.9801
112 G A -0.9072
113 S A 0.0000
114 V A -0.9658
115 Y A 0.0000
116 D A -1.3900
117 I A 0.0000
118 Y A -1.1841
119 R A -0.9176
120 T A -0.5215
121 T A -0.1825
122 R A -0.4122
123 V A 0.5602
124 N A -1.0579
125 Q A -1.1339
126 P A -0.4326
127 S A 0.2202
128 I A 1.2072
129 I A 1.9570
130 G A 0.3941
131 T A -0.1906
132 A A -0.1255
133 T A -0.1405
134 F A 0.0000
135 Y A 0.3339
136 Q A -0.2110
137 Y A 0.0000
138 W A 0.0000
139 S A 0.0000
140 V A 0.0000
141 R A 0.0000
142 R A -2.6061
143 N A -2.5501
144 H A -1.9354
145 R A -1.2608
146 S A -0.6868
147 S A -0.7032
148 G A -0.7797
149 S A -0.4722
150 V A 0.0000
151 N A -0.5414
152 T A 0.0000
153 A A -1.3442
154 N A -1.2703
155 H A 0.0000
156 F A 0.0000
157 N A -2.1283
158 A A -1.6614
159 W A 0.0000
160 A A -1.3705
161 Q A -1.9897
162 Q A -1.7115
163 G A -1.2287
164 L A 0.0000
165 T A -0.7100
166 L A -0.5601
167 G A -0.8331
168 T A -0.7699
169 M A 0.0000
170 D A 0.0000
171 Y A 0.0000
172 Q A 0.0000
173 I A 0.0000
174 V A 0.0000
175 A A 0.0000
176 V A 0.0000
177 E A 0.1229
178 G A 0.0000
179 Y A 1.4736
180 F A 1.5530
181 S A 0.0000
182 S A -1.0564
183 G A -1.5854
184 S A -1.3048
185 A A 0.0000
186 S A -0.6759
187 I A 0.0000
188 T A -0.6869
189 V A 0.0000
190 S A -0.4018
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