Project name: MUT5

Status: done

Started: 2026-08-16 07:31:03
Chain sequence(s) A: QCIQPGTGYNNGYFYSYWNDGHGGVTYCNGPGGQFSVNWSNSGNFVGGKGWQPGTKNKVINFSGSYNPNGNSYLSVYGWTRNPLIEYYIVENFGTYNPSTGATKLGEVTSDGSVYDIYQTQRVNQPSIIGTATFYQYWSVRRNHRSSGTVNTANHFNAWAQLGLTLGTMDYQIVAVEGYFSSGSADITVS
input PDB
Selected Chain(s) A
Distance of aggregation 10 Å
FoldX usage Yes
pH calculations No
alphaCutter usage No
Dynamic mode No
Automated mutations No
Downloads Download all the data
Simulation log 
[INFO]       Logger:   Verbosity set to: 2 - [INFO]                                                (00:00:02)
[WARNING]    runJob:   Working directory already exists (possibly overwriting previous results -ow 
                       to prevent this behavior)                                                   (00:00:02)
[INFO]       runJob:   Starting aggrescan3d job on: input.pdb with A chain(s) selected             (00:00:02)
[INFO]       runJob:   Creating pdb object from: input.pdb                                         (00:00:02)
[INFO]       FoldX:    Starting FoldX energy minimization                                          (00:00:03)
[INFO]       Analysis: Starting Aggrescan4D on folded.pdb                                          (00:02:25)
[INFO]       Main:     Simulation completed successfully.                                          (00:02:27)
Show buried residues
Minimal score value
-2.5691
Maximal score value
1.9446
Average score
-0.4626
Total score value
-87.8888
Download the table (csv)

The table below lists A4D score for protein residues. Residues with A4D score > 0.0000 are marked by yellow rows.

residue index residue name chain Aggrescan4D score mutation
1 Q A -0.7281
2 C A 0.2231
3 I A 0.0021
4 Q A -0.8049
5 P A -0.6543
6 G A -0.4338
7 T A 0.0385
8 G A 0.4516
9 Y A 0.8478
10 N A -0.4715
11 N A -1.3975
12 G A -0.7405
13 Y A -0.1749
14 F A 0.0000
15 Y A 0.2604
16 S A 0.0000
17 Y A 0.0000
18 W A -0.1171
19 N A -0.9184
20 D A -1.4148
21 G A -1.5435
22 H A -1.7900
23 G A -1.6123
24 G A -1.1998
25 V A -1.0968
26 T A -0.4199
27 Y A 0.0000
28 C A -0.2471
29 N A 0.0000
30 G A -0.8627
31 P A -1.0301
32 G A -1.0588
33 G A 0.0000
34 Q A -0.9172
35 F A 0.0000
36 S A -0.8123
37 V A 0.0000
38 N A -1.5489
39 W A 0.0000
40 S A -1.1726
41 N A -1.1655
42 S A 0.0000
43 G A 0.0000
44 N A -0.1075
45 F A 0.0000
46 V A 0.2864
47 G A 0.0000
48 G A 0.0000
49 K A 0.0000
50 G A 0.0000
51 W A 0.0310
52 Q A -0.2803
53 P A -0.4510
54 G A 0.0000
55 T A -0.9242
56 K A -1.7584
57 N A -1.8633
58 K A -0.7335
59 V A 0.3830
60 I A 0.0000
61 N A -0.6797
62 F A 0.0000
63 S A -0.7815
64 G A -0.8202
65 S A -0.9826
66 Y A -1.0866
67 N A -1.8705
68 P A -1.5613
69 N A -1.7415
70 G A -0.5766
71 N A 0.1704
72 S A 0.0000
73 Y A 0.1575
74 L A 0.0000
75 S A 0.0000
76 V A 0.0000
77 Y A 0.0000
78 G A 0.0000
79 W A 0.0000
80 T A 0.0000
81 R A -1.6797
82 N A -1.9923
83 P A -1.2295
84 L A -0.3929
85 I A 0.0000
86 E A 0.0000
87 Y A 0.0000
88 Y A 0.0000
89 I A 0.0000
90 V A 0.0000
91 E A 0.0000
92 N A -1.0436
93 F A -0.3372
94 G A -0.6695
95 T A -0.2692
96 Y A 0.3349
97 N A -0.2900
98 P A -0.1658
99 S A 0.0000
100 T A -0.5190
101 G A -0.8045
102 A A -0.8225
103 T A -1.0096
104 K A -1.8582
105 L A -0.6336
106 G A -1.1653
107 E A -1.7989
108 V A -0.9371
109 T A -0.5089
110 S A 0.0000
111 D A -0.8728
112 G A -0.8674
113 S A 0.0000
114 V A -0.9003
115 Y A 0.0000
116 D A -1.3470
117 I A 0.0000
118 Y A -0.8537
119 Q A -0.5815
120 T A -0.5740
121 Q A -0.6527
122 R A -0.3445
123 V A 0.6000
124 N A -0.9445
125 Q A -0.8903
126 P A -0.2340
127 S A 0.4059
128 I A 1.2862
129 I A 1.9446
130 G A 0.4964
131 T A -0.0805
132 A A 0.0991
133 T A -0.1085
134 F A 0.0000
135 Y A 0.3489
136 Q A 0.0000
137 Y A 0.0000
138 W A 0.0000
139 S A 0.0000
140 V A 0.0000
141 R A 0.0000
142 R A -2.5143
143 N A -2.5691
144 H A -2.0687
145 R A -1.3279
146 S A -0.8018
147 S A -0.6912
148 G A -0.6769
149 T A -0.4067
150 V A 0.0000
151 N A -0.6019
152 T A 0.0000
153 A A -1.3713
154 N A -1.2920
155 H A 0.0000
156 F A 0.0000
157 N A -1.9352
158 A A -1.3423
159 W A 0.0000
160 A A -0.9298
161 Q A -1.3602
162 L A -0.4075
163 G A -0.5896
164 L A 0.0000
165 T A -0.5121
166 L A -0.6490
167 G A -1.0753
168 T A -0.9845
169 M A -0.7383
170 D A 0.0000
171 Y A 0.0000
172 Q A 0.0000
173 I A 0.0000
174 V A 0.0000
175 A A 0.0000
176 V A 0.0000
177 E A 0.0000
178 G A 0.0000
179 Y A 1.5150
180 F A 1.5512
181 S A 0.0000
182 S A -1.0276
183 G A -1.5745
184 S A -1.4321
185 A A 0.0000
186 D A -1.3825
187 I A 0.0000
188 T A -0.7738
189 V A 0.0000
190 S A -0.3557
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