Project name: MUT4

Status: done

Started: 2026-08-16 07:30:44
Chain sequence(s) A: QCIQPGTGYNNGYFYSYWNDGHGGVTYCNGPGGQFSVNWSNSGNFVGGKGWQPGTKNKVINFSGSYNPNGNSYLSVYGWTRNPLIEYYIVENFGTYNPSTGATKLGEVTSDGSVYDIYQTQRVNQPSIIGTATFYQYWSVRRNHRSSGSVNTANHFNAWAQLGLTLGTMDYQIVAVEGYFSSGSADITVS
input PDB
Selected Chain(s) A
Distance of aggregation 10 Å
FoldX usage Yes
pH calculations No
alphaCutter usage No
Dynamic mode No
Automated mutations No
Downloads Download all the data
Simulation log 
[INFO]       Logger:   Verbosity set to: 2 - [INFO]                                                (00:00:02)
[WARNING]    runJob:   Working directory already exists (possibly overwriting previous results -ow 
                       to prevent this behavior)                                                   (00:00:02)
[INFO]       runJob:   Starting aggrescan3d job on: input.pdb with A chain(s) selected             (00:00:02)
[INFO]       runJob:   Creating pdb object from: input.pdb                                         (00:00:02)
[INFO]       FoldX:    Starting FoldX energy minimization                                          (00:00:02)
[INFO]       Analysis: Starting Aggrescan4D on folded.pdb                                          (00:02:11)
[INFO]       Main:     Simulation completed successfully.                                          (00:02:14)
Show buried residues
Minimal score value
-2.4788
Maximal score value
1.9465
Average score
-0.4516
Total score value
-85.8067
Download the table (csv)

The table below lists A4D score for protein residues. Residues with A4D score > 0.0000 are marked by yellow rows.

residue index residue name chain Aggrescan4D score mutation
1 Q A -0.7348
2 C A 0.2195
3 I A 0.0032
4 Q A -0.8012
5 P A -0.6587
6 G A -0.4345
7 T A 0.0294
8 G A 0.4404
9 Y A 0.8508
10 N A -0.4719
11 N A -1.4011
12 G A -0.7357
13 Y A -0.1669
14 F A 0.0000
15 Y A 0.2515
16 S A 0.2376
17 Y A 0.0000
18 W A -0.0656
19 N A -0.8176
20 D A -1.2199
21 G A -1.4346
22 H A -1.6279
23 G A -1.4234
24 G A -1.2073
25 V A -1.0309
26 T A -0.4101
27 Y A 0.0000
28 C A -0.2540
29 N A 0.0000
30 G A -0.8837
31 P A -1.0425
32 G A -1.0647
33 G A 0.0000
34 Q A -0.9157
35 F A 0.0000
36 S A -0.8058
37 V A 0.0000
38 N A -1.5715
39 W A 0.0000
40 S A -1.1605
41 N A -1.1155
42 S A 0.0000
43 G A 0.0000
44 N A 0.0533
45 F A 0.0000
46 V A 0.2626
47 G A 0.0000
48 G A 0.0000
49 K A 0.0000
50 G A 0.0000
51 W A 0.0815
52 Q A -0.2906
53 P A -0.4557
54 G A 0.0000
55 T A -1.0004
56 K A -1.8221
57 N A -2.0093
58 K A -1.0907
59 V A 0.0029
60 I A 0.0000
61 N A -1.0655
62 F A 0.0000
63 S A -0.8292
64 G A -0.7765
65 S A -0.9562
66 Y A -1.0936
67 N A -1.8689
68 P A -1.6181
69 N A -1.7466
70 G A -0.5475
71 N A 0.2036
72 S A 0.0000
73 Y A 0.0000
74 L A 0.0000
75 S A 0.0000
76 V A 0.0000
77 Y A 0.0000
78 G A 0.0000
79 W A 0.0000
80 T A 0.0000
81 R A -1.1302
82 N A -1.7115
83 P A -1.0175
84 L A -0.1954
85 I A 0.0000
86 E A 0.0000
87 Y A 0.0000
88 Y A 0.0000
89 I A 0.0000
90 V A 0.0000
91 E A 0.0000
92 N A -0.9654
93 F A -0.4312
94 G A -0.6911
95 T A -0.2373
96 Y A 0.4579
97 N A -0.2850
98 P A -0.1753
99 S A 0.0000
100 T A -0.5131
101 G A -0.8165
102 A A -0.8673
103 T A -1.0476
104 K A -1.8533
105 L A -0.6081
106 G A -1.1372
107 E A -1.7173
108 V A -0.7996
109 T A -0.4411
110 S A 0.0000
111 D A -0.9478
112 G A -0.8745
113 S A 0.0000
114 V A -0.7121
115 Y A 0.0000
116 D A 0.0000
117 I A 0.0000
118 Y A 0.0000
119 Q A -0.6546
120 T A -0.8417
121 Q A -1.1970
122 R A -1.0684
123 V A 0.2415
124 N A -1.1295
125 Q A -1.1225
126 P A -0.3599
127 S A 0.2594
128 I A 1.2221
129 I A 1.9465
130 G A 0.4411
131 T A -0.1166
132 A A -0.0987
133 T A -0.3654
134 F A 0.0000
135 Y A 0.0502
136 Q A 0.0000
137 Y A 0.0000
138 W A 0.0000
139 S A 0.0000
140 V A 0.0000
141 R A 0.0000
142 R A -2.3396
143 N A -2.4788
144 H A -2.0052
145 R A -1.3061
146 S A -0.7946
147 S A -0.7404
148 G A -0.7945
149 S A -0.6308
150 V A 0.0000
151 N A -0.8162
152 T A 0.0000
153 A A 0.0000
154 N A -1.3393
155 H A 0.0000
156 F A 0.0000
157 N A -1.9239
158 A A -1.3348
159 W A 0.0000
160 A A -0.9188
161 Q A -1.3551
162 L A -0.4094
163 G A -0.5848
164 L A 0.0000
165 T A -0.5089
166 L A -0.5561
167 G A -0.8742
168 T A -0.7846
169 M A -0.6053
170 D A 0.0000
171 Y A 0.0000
172 Q A 0.0000
173 I A 0.0000
174 V A 0.0000
175 A A 0.0000
176 V A 0.0000
177 E A 0.1036
178 G A 0.0000
179 Y A 1.7015
180 F A 1.6510
181 S A 0.0000
182 S A -1.0119
183 G A -1.5719
184 S A -1.4257
185 A A 0.0000
186 D A -1.3563
187 I A 0.0000
188 T A -0.8063
189 V A 0.0000
190 S A -0.4877
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