Project name: MUT2

Status: done

Started: 2026-08-16 07:29:56
Chain sequence(s) A: QCIQPGTGYNNGYFYSYWNDGHGGVTYCNGPGGQFSVNWSNSGNFVGGKGWQPGTKNKVINFSGSYNPNGNSYLSVYGWTRNPLIEYYIVENFGTYNPSTGATKLGEVTSDGSVYDIYRTQRVNQPSIIGTATFYQYWSVRRNHRSSGSVNTANHFNAWAQQGLTLGTMDYQIVAVEGYFSSGSADITVS
input PDB
Selected Chain(s) A
Distance of aggregation 10 Å
FoldX usage Yes
pH calculations No
alphaCutter usage No
Dynamic mode No
Automated mutations No
Downloads Download all the data
Simulation log 
[INFO]       Logger:   Verbosity set to: 2 - [INFO]                                                (00:00:02)
[WARNING]    runJob:   Working directory already exists (possibly overwriting previous results -ow 
                       to prevent this behavior)                                                   (00:00:02)
[INFO]       runJob:   Starting aggrescan3d job on: input.pdb with A chain(s) selected             (00:00:02)
[INFO]       runJob:   Creating pdb object from: input.pdb                                         (00:00:02)
[INFO]       FoldX:    Starting FoldX energy minimization                                          (00:00:03)
[INFO]       Analysis: Starting Aggrescan4D on folded.pdb                                          (00:02:41)
[INFO]       Main:     Simulation completed successfully.                                          (00:02:44)
Show buried residues
Minimal score value
-2.5688
Maximal score value
1.9283
Average score
-0.5104
Total score value
-96.9835
Download the table (csv)

The table below lists A4D score for protein residues. Residues with A4D score > 0.0000 are marked by yellow rows.

residue index residue name chain Aggrescan4D score mutation
1 Q A -0.7312
2 C A 0.2119
3 I A -0.0226
4 Q A -0.8192
5 P A -0.7215
6 G A -0.4440
7 T A 0.0323
8 G A 0.4478
9 Y A 0.8458
10 N A -0.4868
11 N A -1.4156
12 G A -0.7559
13 Y A -0.1987
14 F A 0.0000
15 Y A 0.2604
16 S A 0.0000
17 Y A 0.0000
18 W A -0.2030
19 N A -0.9831
20 D A -1.4470
21 G A -1.5427
22 H A -1.7730
23 G A -1.5989
24 G A -1.2044
25 V A -1.0853
26 T A -0.4238
27 Y A 0.0000
28 C A -0.2520
29 N A 0.0000
30 G A -0.8658
31 P A -1.0463
32 G A -1.0906
33 G A 0.0000
34 Q A -0.9280
35 F A 0.0000
36 S A -0.8079
37 V A 0.0000
38 N A -1.5517
39 W A 0.0000
40 S A -1.1738
41 N A -1.1629
42 S A 0.0000
43 G A 0.0000
44 N A -0.0657
45 F A 0.0000
46 V A 0.0000
47 G A 0.0000
48 G A 0.0000
49 K A 0.0000
50 G A 0.0000
51 W A 0.0288
52 Q A -0.2689
53 P A -0.4428
54 G A 0.0000
55 T A -1.0181
56 K A -1.8517
57 N A -2.0252
58 K A -1.0812
59 V A -0.0012
60 I A 0.0000
61 N A -1.0504
62 F A 0.0000
63 S A -0.8504
64 G A -0.8249
65 S A -0.9837
66 Y A -1.1050
67 N A -1.8804
68 P A -1.5979
69 N A -1.7295
70 G A -0.6025
71 N A 0.1089
72 S A 0.0000
73 Y A 0.0000
74 L A 0.0000
75 S A 0.0000
76 V A 0.0000
77 Y A 0.0000
78 G A 0.0000
79 W A 0.0000
80 T A 0.0000
81 R A -1.6869
82 N A -1.9898
83 P A -1.2500
84 L A -0.4293
85 I A 0.0000
86 E A 0.0000
87 Y A 0.0000
88 Y A 0.0000
89 I A 0.0000
90 V A 0.0000
91 E A 0.0000
92 N A -1.0742
93 F A -0.4125
94 G A -0.6222
95 T A -0.2913
96 Y A 0.2832
97 N A -0.3062
98 P A 0.0000
99 S A 0.0000
100 T A -0.5050
101 G A -0.8259
102 A A -0.9001
103 T A -1.0627
104 K A -1.7643
105 L A -0.9147
106 G A -1.3418
107 E A -1.8396
108 V A -0.8906
109 T A -0.4776
110 S A 0.0000
111 D A -0.9300
112 G A -0.8847
113 S A 0.0000
114 V A -0.8309
115 Y A 0.0000
116 D A 0.0000
117 I A 0.0000
118 Y A 0.0000
119 R A -1.0099
120 T A -0.9324
121 Q A -1.1029
122 R A -0.9650
123 V A 0.2848
124 N A -1.1246
125 Q A -1.1513
126 P A -0.3624
127 S A 0.3061
128 I A 1.2573
129 I A 1.9283
130 G A 0.4619
131 T A -0.2241
132 A A -0.0461
133 T A -0.3457
134 F A 0.0000
135 Y A -0.0802
136 Q A 0.0000
137 Y A 0.0000
138 W A 0.0000
139 S A 0.0000
140 V A 0.0000
141 R A 0.0000
142 R A -2.5115
143 N A -2.5688
144 H A -2.0373
145 R A -1.3237
146 S A -0.7997
147 S A -0.7525
148 G A -0.7988
149 S A -0.6246
150 V A 0.0000
151 N A -0.8041
152 T A 0.0000
153 A A -1.4605
154 N A -1.3510
155 H A 0.0000
156 F A 0.0000
157 N A -2.0938
158 A A -1.6364
159 W A 0.0000
160 A A -1.3280
161 Q A -1.9344
162 Q A -1.6095
163 G A -1.1665
164 L A 0.0000
165 T A -0.6788
166 L A -0.6400
167 G A -1.0714
168 T A -0.9840
169 M A -0.7435
170 D A 0.0000
171 Y A 0.0000
172 Q A 0.0000
173 I A 0.0000
174 V A 0.0000
175 A A 0.0000
176 V A 0.0000
177 E A -0.0200
178 G A 0.0000
179 Y A 1.3714
180 F A 1.5408
181 S A 0.0000
182 S A -1.0413
183 G A -1.5650
184 S A -1.4276
185 A A 0.0000
186 D A -1.3791
187 I A 0.0000
188 T A -0.8194
189 V A 0.0000
190 S A -0.4919
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