Project name: MUT10

Status: done

Started: 2026-08-16 07:41:42
Chain sequence(s) A: QCISPGTGYNNGYFYSYWNDGRGGVTYCNGPGGQFSVNWSNSGNFVGGKGWQPGTKNKVINFSGSYNPNGNSYLSVYGWTRNPLIEYYIVENFGTYNPSTGATKLGEVTSDGSVYDIYQTTRVNQPSIIGTATFDQYWSVRRNHRSSGTVNTANHFNAWAALGLTLGTMDYQIVAVEGYFSSGSADITVS
input PDB
Selected Chain(s) A
Distance of aggregation 10 Å
FoldX usage Yes
pH calculations No
alphaCutter usage No
Dynamic mode No
Automated mutations No
Downloads Download all the data
Simulation log 
[INFO]       Logger:   Verbosity set to: 2 - [INFO]                                                (00:00:02)
[WARNING]    runJob:   Working directory already exists (possibly overwriting previous results -ow 
                       to prevent this behavior)                                                   (00:00:02)
[INFO]       runJob:   Starting aggrescan3d job on: input.pdb with A chain(s) selected             (00:00:02)
[INFO]       runJob:   Creating pdb object from: input.pdb                                         (00:00:02)
[INFO]       FoldX:    Starting FoldX energy minimization                                          (00:00:02)
[INFO]       Analysis: Starting Aggrescan4D on folded.pdb                                          (00:02:16)
[INFO]       Main:     Simulation completed successfully.                                          (00:02:18)
Show buried residues
Minimal score value
-2.4616
Maximal score value
1.9501
Average score
-0.4363
Total score value
-82.8984
Download the table (csv)

The table below lists A4D score for protein residues. Residues with A4D score > 0.0000 are marked by yellow rows.

residue index residue name chain Aggrescan4D score mutation
1 Q A -0.7324
2 C A 0.4156
3 I A 0.4599
4 S A 0.1382
5 P A -0.2373
6 G A -0.2260
7 T A 0.1304
8 G A 0.4503
9 Y A 0.8513
10 N A -0.4710
11 N A -1.4077
12 G A -0.7467
13 Y A -0.1910
14 F A 0.0000
15 Y A 0.2568
16 S A 0.0000
17 Y A 0.0000
18 W A 0.0880
19 N A -0.7563
20 D A -1.1663
21 G A -1.6776
22 R A -2.3662
23 G A -1.7494
24 G A -1.3686
25 V A -1.0382
26 T A -0.2633
27 Y A 0.0000
28 C A -0.1315
29 N A 0.0000
30 G A -0.8842
31 P A -1.0498
32 G A -1.0877
33 G A 0.0000
34 Q A -0.9206
35 F A 0.0000
36 S A -0.8061
37 V A 0.0000
38 N A -1.5647
39 W A 0.0000
40 S A -1.1487
41 N A -1.2572
42 S A 0.0000
43 G A 0.0000
44 N A -0.1199
45 F A 0.0000
46 V A 0.2141
47 G A 0.0000
48 G A 0.0000
49 K A 0.0000
50 G A 0.0000
51 W A 0.0342
52 Q A -0.2670
53 P A -0.4739
54 G A -0.6974
55 T A -0.9686
56 K A -1.7876
57 N A -1.8753
58 K A -0.7463
59 V A 0.3763
60 I A 0.0000
61 N A -0.7011
62 F A 0.0000
63 S A -0.7518
64 G A -0.7583
65 S A -0.9552
66 Y A -1.0910
67 N A -1.8695
68 P A -1.5993
69 N A -1.7362
70 G A -0.6203
71 N A 0.1041
72 S A 0.0000
73 Y A 0.0000
74 L A 0.0000
75 S A 0.0000
76 V A 0.0000
77 Y A 0.0000
78 G A 0.0000
79 W A 0.0000
80 T A 0.0000
81 R A -1.1856
82 N A -1.7514
83 P A -1.2367
84 L A -0.4867
85 I A 0.0000
86 E A 0.0000
87 Y A 0.0000
88 Y A 0.0000
89 I A 0.0000
90 V A 0.0000
91 E A 0.0000
92 N A -0.9380
93 F A -0.4072
94 G A -0.6914
95 T A -0.2825
96 Y A 0.2943
97 N A -0.3104
98 P A -0.1889
99 S A 0.0000
100 T A -0.5353
101 G A -0.8407
102 A A -0.8031
103 T A -1.0411
104 K A -1.9665
105 L A -0.7661
106 G A -1.0430
107 E A -1.7323
108 V A -0.8195
109 T A -0.4454
110 S A 0.0000
111 D A -0.8855
112 G A -0.8472
113 S A 0.0000
114 V A -0.6946
115 Y A 0.0000
116 D A 0.0000
117 I A 0.0000
118 Y A 0.0000
119 Q A -0.9837
120 T A -0.8224
121 T A -0.7196
122 R A -0.9151
123 V A 0.3175
124 N A -1.0603
125 Q A -1.0934
126 P A -0.3990
127 S A 0.2431
128 I A 1.2279
129 I A 1.9501
130 G A 0.4286
131 T A -0.1487
132 A A -0.1927
133 T A -0.4421
134 F A 0.0000
135 D A -0.8435
136 Q A 0.0000
137 Y A 0.0000
138 W A 0.0000
139 S A 0.0000
140 V A 0.0000
141 R A 0.0000
142 R A -2.2938
143 N A -2.4616
144 H A -1.9952
145 R A -1.2892
146 S A -0.7839
147 S A -0.6677
148 G A -0.6815
149 T A -0.4206
150 V A 0.0000
151 N A -0.6155
152 T A 0.0000
153 A A -1.3878
154 N A -1.3279
155 H A 0.0000
156 F A 0.0000
157 N A -1.6098
158 A A -0.8892
159 W A 0.0000
160 A A -0.2963
161 A A -0.0696
162 L A 0.2500
163 G A -0.1651
164 L A 0.0000
165 T A -0.3200
166 L A -0.5784
167 G A -0.9189
168 T A -0.8576
169 M A 0.0000
170 D A 0.0000
171 Y A 0.0000
172 Q A 0.0000
173 I A 0.0000
174 V A 0.0000
175 A A 0.0000
176 V A 0.0000
177 E A 0.0208
178 G A 0.0000
179 Y A 1.3985
180 F A 1.4100
181 S A 0.0000
182 S A -1.0502
183 G A -1.5691
184 S A -1.4314
185 A A 0.0000
186 D A -1.3638
187 I A 0.0000
188 T A -0.7595
189 V A 0.0000
190 S A -0.3680
Download PDB file
View in 3Dmol