| Chain sequence(s) |
A: MNQSVSSLAEKDIQYQLHPFTNARLHQELGPLIIERGQGIYVYDDQGKGYIEAMAGLGSVALGFSNQRLIKAAEQQFNTLPFYHLANHKSHRPSIELAEKLIEMAPVPMSKVFFTNSGSEANDTVVKFVWYLNNALGKPAKKKFISRVNGYHGSTVASASLTGFPGNQRGFDLPLPGFLHVGCPHHYRFALAGESEEHFADRLAVELEQKILAEGPETIAAFIGEPLMGAGGAIVPPRTYWEKIQKVCRKYDILVIADEVMCGFGRTGQMFGSQTFGIQPDIMVLSKQLSSSYQPIAAILINAPVFEGIADQSQALGALGHGFTGSGHPVATAVALENLKIIEEESLVEHAAQMGQLLRSGLQHFIDHPLVGEIRGCGLIAAVELVGDRVSKAPYQALGTLGRYMAGRAQEHGMITDAMGDAVAFCPPLIVNEQEVGMIVERFARALDDTTQWVGE
B: MNQSVSSLAEKDIQYQLHPFTNARLHQELGPLIIERGQGIYVYDDQGKGYIEAMAGLGSVALGFSNQRLIKAAEQQFNTLPFYHLANHKSHRPSIELAEKLIEMAPVPMSKVFFTNSGSEANDTVVKFVWYLNNALGKPAKKKFISRVNGYHGSTVASASLTGFPGNQRGFDLPLPGFLHVGCPHHYRFALAGESEEHFADRLAVELEQKILAEGPETIAAFIGEPLMGAGGAIVPPRTYWEKIQKVCRKYDILVIADEVMCGFGRTGQMFGSQTFGIQPDIMVLSKQLSSSYQPIAAILINAPVFEGIADQSQALGALGHGFTGSGHPVATAVALENLKIIEEESLVEHAAQMGQLLRSGLQHFIDHPLVGEIRGCGLIAAVELVGDRVSKAPYQALGTLGRYMAGRAQEHGMITDAMGDAVAFCPPLIVNEQEVGMIVERFARALDDTTQWVGE input PDB |
| Selected Chain(s) | A,B |
| Distance of aggregation | 10 Å |
| FoldX usage | Yes |
| pH calculations | No |
| alphaCutter usage | No |
| Dynamic mode | No |
| Automated mutations | No |
| Mutated residues | LD191B,LA398A,FD164B |
| Energy difference between WT (input) and mutated protein (by FoldX) | 1.96616 kcal/mol
CAUTION: Your mutation/s can destabilize the protein structure |
| Downloads | Download all the data |
| Simulation log |
[INFO] Logger: Verbosity set to: 2 - [INFO] (00:00:07)
[WARNING] runJob: Working directory already exists (possibly overwriting previous results -ow
to prevent this behavior) (00:00:07)
[INFO] runJob: Starting aggrescan3d job on: input.pdb with all chain(s) selected (00:00:07)
[INFO] runJob: Creating pdb object from: input.pdb (00:00:07)
[INFO] FoldX: Starting FoldX energy minimization (00:00:08)
[INFO] FoldX: Building mutant model (00:04:46)
[INFO] Analysis: Starting Aggrescan4D on folded.pdb (00:05:10)
[INFO] Main: Simulation completed successfully. (00:05:21)
|
The table below lists A4D score for protein residues. Residues with A4D score > 0.0000 are marked by yellow rows.
| residue index | residue name | chain | Aggrescan4D score | mutation |
|---|---|---|---|---|
| 1 | M | A | 0.0115 | |
| 2 | N | A | -1.0565 | |
| 3 | Q | A | -0.9134 | |
| 4 | S | A | -0.1055 | |
| 5 | V | A | 0.8781 | |
| 6 | S | A | -0.0405 | |
| 7 | S | A | 0.0682 | |
| 8 | L | A | -0.4596 | |
| 9 | A | A | -0.5908 | |
| 10 | E | A | -1.0427 | |
| 11 | K | A | -0.8272 | |
| 12 | D | A | 0.0000 | |
| 13 | I | A | -0.6308 | |
| 14 | Q | A | -0.9479 | |
| 15 | Y | A | -0.7219 | |
| 16 | Q | A | 0.0000 | |
| 17 | L | A | 0.0000 | |
| 18 | H | A | 0.0000 | |
| 19 | P | A | 0.0000 | |
| 20 | F | A | -0.0997 | |
| 21 | T | A | 0.0000 | |
| 22 | N | A | -0.9139 | |
| 23 | A | A | 0.0000 | |
| 24 | R | A | -1.5219 | |
| 25 | L | A | -0.2643 | |
| 26 | H | A | 0.0000 | |
| 27 | Q | A | -1.1342 | |
| 28 | E | A | -1.1779 | |
| 29 | L | A | 0.7051 | |
| 30 | G | A | 0.0000 | |
| 31 | P | A | -0.1371 | |
| 32 | L | A | -0.0712 | |
| 33 | I | A | 0.0000 | |
| 34 | I | A | 0.0000 | |
| 35 | E | A | -1.8914 | |
| 36 | R | A | -2.1259 | |
| 37 | G | A | -1.3157 | |
| 38 | Q | A | -1.4476 | |
| 39 | G | A | -0.4692 | |
| 40 | I | A | 0.0000 | |
| 41 | Y | A | -0.3489 | |
| 42 | V | A | 0.0000 | |
| 43 | Y | A | -1.4791 | |
| 44 | D | A | -1.8878 | |
| 45 | D | A | -2.6276 | |
| 46 | Q | A | -2.3606 | |
| 47 | G | A | -2.0291 | |
| 48 | K | A | -1.8320 | |
| 49 | G | A | -1.1807 | |
| 50 | Y | A | 0.0000 | |
| 51 | I | A | 0.0000 | |
| 52 | E | A | 0.0000 | |
| 53 | A | A | 0.0000 | |
| 54 | M | A | 0.0000 | |
| 55 | A | A | 0.0000 | |
| 56 | G | A | 0.0000 | |
| 57 | L | A | 0.2154 | |
| 58 | G | A | 0.0000 | |
| 59 | S | A | 0.0000 | |
| 60 | V | A | 0.0000 | |
| 61 | A | A | 0.0000 | |
| 62 | L | A | 0.0000 | |
| 63 | G | A | 0.0000 | |
| 64 | F | A | 0.0000 | |
| 65 | S | A | -1.3336 | |
| 66 | N | A | -1.5406 | |
| 67 | Q | A | -2.2437 | |
| 68 | R | A | -2.0158 | |
| 69 | L | A | 0.0000 | |
| 70 | I | A | 0.0000 | |
| 71 | K | A | -2.9620 | |
| 72 | A | A | -1.8420 | |
| 73 | A | A | 0.0000 | |
| 74 | E | A | -2.5649 | |
| 75 | Q | A | -2.3894 | |
| 76 | Q | A | -1.6334 | |
| 77 | F | A | 0.0000 | |
| 78 | N | A | -2.1365 | |
| 79 | T | A | -1.6476 | |
| 80 | L | A | 0.0000 | |
| 81 | P | A | 0.0000 | |
| 82 | F | A | 0.0000 | |
| 83 | Y | A | 0.0000 | |
| 84 | H | A | 0.0000 | |
| 85 | L | A | 0.0000 | |
| 86 | A | A | 0.0000 | |
| 87 | N | A | -1.2535 | |
| 88 | H | A | -0.3201 | |
| 89 | K | A | 0.0000 | |
| 90 | S | A | 0.0000 | |
| 91 | H | A | 0.0000 | |
| 92 | R | A | -1.4852 | |
| 93 | P | A | 0.0000 | |
| 94 | S | A | 0.0000 | |
| 95 | I | A | 0.0000 | |
| 96 | E | A | -0.9501 | |
| 97 | L | A | 0.0000 | |
| 98 | A | A | 0.0000 | |
| 99 | E | A | -1.2274 | |
| 100 | K | A | -1.1204 | |
| 101 | L | A | 0.0000 | |
| 102 | I | A | -0.9405 | |
| 103 | E | A | -1.8298 | |
| 104 | M | A | -0.7614 | |
| 105 | A | A | -0.5341 | |
| 106 | P | A | -0.6419 | |
| 107 | V | A | -0.5625 | |
| 108 | P | A | -0.5792 | |
| 109 | M | A | 0.0000 | |
| 110 | S | A | -0.5812 | |
| 111 | K | A | 0.0000 | |
| 112 | V | A | 0.0000 | |
| 113 | F | A | 0.0000 | |
| 114 | F | A | 0.0000 | |
| 115 | T | A | 0.0000 | |
| 116 | N | A | 0.0000 | |
| 117 | S | A | 0.0000 | |
| 118 | G | A | -0.0362 | |
| 119 | S | A | 0.0000 | |
| 120 | E | A | 0.0000 | |
| 121 | A | A | 0.0000 | |
| 122 | N | A | 0.0000 | |
| 123 | D | A | 0.0000 | |
| 124 | T | A | 0.0000 | |
| 125 | V | A | 0.0000 | |
| 126 | V | A | 0.0000 | |
| 127 | K | A | 0.0000 | |
| 128 | F | A | 0.0000 | |
| 129 | V | A | 0.0000 | |
| 130 | W | A | 0.0000 | |
| 131 | Y | A | 0.0000 | |
| 132 | L | A | 0.0000 | |
| 133 | N | A | 0.0000 | |
| 134 | N | A | -1.0586 | |
| 135 | A | A | -0.5408 | |
| 136 | L | A | 0.0555 | |
| 137 | G | A | -0.8407 | |
| 138 | K | A | -1.9584 | |
| 139 | P | A | -1.4659 | |
| 140 | A | A | -1.1764 | |
| 141 | K | A | 0.0000 | |
| 142 | K | A | -1.1194 | |
| 143 | K | A | -0.7670 | |
| 144 | F | A | 0.0000 | |
| 145 | I | A | 0.0000 | |
| 146 | S | A | 0.0000 | |
| 147 | R | A | 0.0000 | |
| 148 | V | A | 0.7704 | |
| 149 | N | A | 0.2181 | |
| 150 | G | A | 0.0000 | |
| 151 | Y | A | 0.4823 | |
| 152 | H | A | 0.0000 | |
| 153 | G | A | 0.0000 | |
| 154 | S | A | 0.0000 | |
| 155 | T | A | 0.0000 | |
| 156 | V | A | 0.0000 | |
| 157 | A | A | 0.0000 | |
| 158 | S | A | 0.0000 | |
| 159 | A | A | 0.0000 | |
| 160 | S | A | 0.0000 | |
| 161 | L | A | 0.0000 | |
| 162 | T | A | 0.0000 | |
| 163 | G | A | 0.2780 | |
| 164 | F | A | -0.0644 | |
| 165 | P | A | -0.8174 | |
| 166 | G | A | -0.9964 | |
| 167 | N | A | 0.0000 | |
| 168 | Q | A | -1.5589 | |
| 169 | R | A | -2.3934 | |
| 170 | G | A | -1.5375 | |
| 171 | F | A | 0.0000 | |
| 172 | D | A | -1.9079 | |
| 173 | L | A | 0.0000 | |
| 174 | P | A | -0.8113 | |
| 175 | L | A | 0.0000 | |
| 176 | P | A | -0.3811 | |
| 177 | G | A | -0.4992 | |
| 178 | F | A | 0.0000 | |
| 179 | L | A | -0.0770 | |
| 180 | H | A | -0.0277 | |
| 181 | V | A | 0.0000 | |
| 182 | G | A | 0.0053 | |
| 183 | C | A | 0.0000 | |
| 184 | P | A | 0.0000 | |
| 185 | H | A | 0.0000 | |
| 186 | H | A | 0.0437 | |
| 187 | Y | A | 0.0078 | |
| 188 | R | A | -0.1173 | |
| 189 | F | A | 0.9828 | |
| 190 | A | A | 0.5693 | |
| 191 | L | A | 1.3105 | |
| 192 | A | A | 0.6477 | |
| 193 | G | A | -0.3027 | |
| 194 | E | A | -0.4158 | |
| 195 | S | A | -1.2648 | |
| 196 | E | A | -2.0927 | |
| 197 | E | A | -2.4324 | |
| 198 | H | A | -2.3409 | |
| 199 | F | A | 0.0000 | |
| 200 | A | A | 0.0000 | |
| 201 | D | A | -2.1746 | |
| 202 | R | A | -1.4138 | |
| 203 | L | A | 0.0000 | |
| 204 | A | A | 0.0000 | |
| 205 | V | A | -0.0385 | |
| 206 | E | A | -1.0821 | |
| 207 | L | A | 0.0000 | |
| 208 | E | A | -1.0301 | |
| 209 | Q | A | -1.1763 | |
| 210 | K | A | -0.8918 | |
| 211 | I | A | 0.0000 | |
| 212 | L | A | -0.0968 | |
| 213 | A | A | -0.2185 | |
| 214 | E | A | -0.6884 | |
| 215 | G | A | -0.7111 | |
| 216 | P | A | -1.4216 | |
| 217 | E | A | -2.3917 | |
| 218 | T | A | -1.3199 | |
| 219 | I | A | 0.0000 | |
| 220 | A | A | 0.0000 | |
| 221 | A | A | 0.0000 | |
| 222 | F | A | 0.0000 | |
| 223 | I | A | 0.0000 | |
| 224 | G | A | 0.0000 | |
| 225 | E | A | 0.0000 | |
| 226 | P | A | 0.0000 | |
| 227 | L | A | 0.0000 | |
| 228 | M | A | 0.0000 | |
| 229 | G | A | 0.0000 | |
| 230 | A | A | 0.1362 | |
| 231 | G | A | 0.1658 | |
| 232 | G | A | 0.0000 | |
| 233 | A | A | 0.0000 | |
| 234 | I | A | 0.0000 | |
| 235 | V | A | 0.3048 | |
| 236 | P | A | 0.0000 | |
| 237 | P | A | 0.0000 | |
| 238 | R | A | -2.4713 | |
| 239 | T | A | -2.2212 | |
| 240 | Y | A | 0.0000 | |
| 241 | W | A | 0.0000 | |
| 242 | E | A | -2.8560 | |
| 243 | K | A | -2.2115 | |
| 244 | I | A | 0.0000 | |
| 245 | Q | A | -2.5529 | |
| 246 | K | A | -3.3469 | |
| 247 | V | A | -2.2297 | |
| 248 | C | A | 0.0000 | |
| 249 | R | A | -3.6767 | |
| 250 | K | A | -3.4676 | |
| 251 | Y | A | -2.5016 | |
| 252 | D | A | -2.9930 | |
| 253 | I | A | 0.0000 | |
| 254 | L | A | -0.5427 | |
| 255 | V | A | 0.0000 | |
| 256 | I | A | 0.0000 | |
| 257 | A | A | 0.0000 | |
| 258 | D | A | 0.0000 | |
| 259 | E | A | 0.0000 | |
| 260 | V | A | 0.2311 | |
| 261 | M | A | 0.2447 | |
| 262 | C | A | 0.0000 | |
| 263 | G | A | 0.0000 | |
| 264 | F | A | 0.0000 | |
| 265 | G | A | 0.0000 | |
| 266 | R | A | 0.0000 | |
| 267 | T | A | 0.0000 | |
| 268 | G | A | -1.2556 | |
| 269 | Q | A | -1.3442 | |
| 270 | M | A | -0.8519 | |
| 271 | F | A | 0.0000 | |
| 272 | G | A | 0.0000 | |
| 273 | S | A | 0.0000 | |
| 274 | Q | A | -1.2733 | |
| 275 | T | A | -0.6234 | |
| 276 | F | A | -0.8447 | |
| 277 | G | A | -1.2731 | |
| 278 | I | A | 0.0000 | |
| 279 | Q | A | -1.6143 | |
| 280 | P | A | 0.0000 | |
| 281 | D | A | 0.0000 | |
| 282 | I | A | 0.0000 | |
| 283 | M | A | 0.0000 | |
| 284 | V | A | 0.0000 | |
| 285 | L | A | 0.0000 | |
| 286 | S | A | 0.0000 | |
| 287 | K | A | -0.1195 | |
| 288 | Q | A | 0.0000 | |
| 289 | L | A | 0.0000 | |
| 290 | S | A | 0.0000 | |
| 291 | S | A | 0.0000 | |
| 292 | S | A | 0.0000 | |
| 293 | Y | A | 0.0000 | |
| 294 | Q | A | 0.0000 | |
| 295 | P | A | 0.0000 | |
| 296 | I | A | 0.0000 | |
| 297 | A | A | 0.0000 | |
| 298 | A | A | 0.0000 | |
| 299 | I | A | 0.0000 | |
| 300 | L | A | 0.0000 | |
| 301 | I | A | 0.0000 | |
| 302 | N | A | -0.3500 | |
| 303 | A | A | -0.4768 | |
| 304 | P | A | -0.5889 | |
| 305 | V | A | 0.0000 | |
| 306 | F | A | 0.0000 | |
| 307 | E | A | -1.5531 | |
| 308 | G | A | -0.9125 | |
| 309 | I | A | 0.0000 | |
| 310 | A | A | 0.0000 | |
| 311 | D | A | -2.2505 | |
| 312 | Q | A | -1.4920 | |
| 313 | S | A | 0.0000 | |
| 314 | Q | A | -1.7382 | |
| 315 | A | A | -0.9982 | |
| 316 | L | A | -0.7843 | |
| 317 | G | A | -0.8367 | |
| 318 | A | A | -0.6528 | |
| 319 | L | A | 0.0000 | |
| 320 | G | A | -0.2609 | |
| 321 | H | A | 0.0000 | |
| 322 | G | A | 0.0000 | |
| 323 | F | A | 0.0000 | |
| 324 | T | A | -0.0159 | |
| 325 | G | A | -0.0473 | |
| 326 | S | A | 0.0000 | |
| 327 | G | A | 0.0000 | |
| 328 | H | A | 0.0000 | |
| 329 | P | A | 0.0000 | |
| 330 | V | A | 0.0000 | |
| 331 | A | A | 0.0000 | |
| 332 | T | A | 0.0000 | |
| 333 | A | A | -0.4483 | |
| 334 | V | A | 0.0000 | |
| 335 | A | A | 0.0000 | |
| 336 | L | A | -0.3304 | |
| 337 | E | A | -0.7563 | |
| 338 | N | A | 0.0000 | |
| 339 | L | A | 0.0000 | |
| 340 | K | A | -2.3049 | |
| 341 | I | A | 0.0000 | |
| 342 | I | A | 0.0000 | |
| 343 | E | A | -3.7404 | |
| 344 | E | A | -3.8458 | |
| 345 | E | A | -3.6038 | |
| 346 | S | A | -2.8512 | |
| 347 | L | A | 0.0000 | |
| 348 | V | A | -1.6834 | |
| 349 | E | A | -2.7344 | |
| 350 | H | A | -1.8250 | |
| 351 | A | A | 0.0000 | |
| 352 | A | A | -1.5399 | |
| 353 | Q | A | -2.0501 | |
| 354 | M | A | 0.0000 | |
| 355 | G | A | 0.0000 | |
| 356 | Q | A | -1.3975 | |
| 357 | L | A | -0.8590 | |
| 358 | L | A | 0.0000 | |
| 359 | R | A | -1.0897 | |
| 360 | S | A | -0.9951 | |
| 361 | G | A | -1.0583 | |
| 362 | L | A | 0.0000 | |
| 363 | Q | A | -1.5620 | |
| 364 | H | A | -1.5332 | |
| 365 | F | A | -0.7481 | |
| 366 | I | A | -0.6458 | |
| 367 | D | A | -1.8837 | |
| 368 | H | A | -0.9914 | |
| 369 | P | A | -1.2326 | |
| 370 | L | A | 0.0000 | |
| 371 | V | A | 0.0000 | |
| 372 | G | A | -0.5925 | |
| 373 | E | A | -0.5050 | |
| 374 | I | A | -0.0840 | |
| 375 | R | A | 0.0000 | |
| 376 | G | A | -0.0524 | |
| 377 | C | A | -0.1727 | |
| 378 | G | A | 0.0000 | |
| 379 | L | A | 0.0000 | |
| 380 | I | A | 0.0000 | |
| 381 | A | A | 0.0000 | |
| 382 | A | A | 0.0000 | |
| 383 | V | A | 0.0000 | |
| 384 | E | A | 0.0000 | |
| 385 | L | A | 0.0000 | |
| 386 | V | A | 0.0000 | |
| 387 | G | A | -1.0363 | |
| 388 | D | A | -0.9383 | |
| 389 | R | A | -0.9057 | |
| 390 | V | A | 0.8689 | |
| 391 | S | A | -0.0769 | |
| 392 | K | A | -0.7189 | |
| 393 | A | A | -0.5793 | |
| 394 | P | A | -0.7515 | |
| 395 | Y | A | -0.5732 | |
| 396 | Q | A | -1.0666 | |
| 397 | A | A | -0.4926 | |
| 398 | A | A | -0.4165 | mutated: LA398A |
| 399 | G | A | 0.0000 | |
| 400 | T | A | -0.8299 | |
| 401 | L | A | 0.0000 | |
| 402 | G | A | 0.0000 | |
| 403 | R | A | -1.9302 | |
| 404 | Y | A | -0.8993 | |
| 405 | M | A | 0.0000 | |
| 406 | A | A | -1.2980 | |
| 407 | G | A | -1.5467 | |
| 408 | R | A | -2.2962 | |
| 409 | A | A | 0.0000 | |
| 410 | Q | A | -1.6314 | |
| 411 | E | A | -2.6437 | |
| 412 | H | A | -2.0235 | |
| 413 | G | A | 0.0000 | |
| 414 | M | A | 0.0000 | |
| 415 | I | A | 0.0000 | |
| 416 | T | A | 0.0000 | |
| 417 | D | A | -0.9005 | |
| 418 | A | A | -0.6535 | |
| 419 | M | A | -0.1884 | |
| 420 | G | A | -0.5001 | |
| 421 | D | A | 0.0000 | |
| 422 | A | A | 0.0000 | |
| 423 | V | A | 0.0000 | |
| 424 | A | A | 0.0000 | |
| 425 | F | A | 0.0000 | |
| 426 | C | A | 0.0000 | |
| 427 | P | A | 0.0000 | |
| 428 | P | A | 0.0000 | |
| 429 | L | A | 0.0000 | |
| 430 | I | A | 0.1291 | |
| 431 | V | A | 0.0000 | |
| 432 | N | A | -1.7900 | |
| 433 | E | A | -2.6913 | |
| 434 | Q | A | -2.3708 | |
| 435 | E | A | -1.6741 | |
| 436 | V | A | 0.0000 | |
| 437 | G | A | -1.6112 | |
| 438 | M | A | -1.3224 | |
| 439 | I | A | 0.0000 | |
| 440 | V | A | -1.3459 | |
| 441 | E | A | -2.3354 | |
| 442 | R | A | -2.0438 | |
| 443 | F | A | 0.0000 | |
| 444 | A | A | -2.0491 | |
| 445 | R | A | -3.2376 | |
| 446 | A | A | 0.0000 | |
| 447 | L | A | 0.0000 | |
| 448 | D | A | -3.0673 | |
| 449 | D | A | -2.1019 | |
| 450 | T | A | 0.0000 | |
| 451 | T | A | -2.0671 | |
| 452 | Q | A | -2.1507 | |
| 453 | W | A | -0.7860 | |
| 454 | V | A | -0.8528 | |
| 455 | G | A | -1.5570 | |
| 456 | E | A | -2.4684 | |
| 1 | M | B | 0.0646 | |
| 2 | N | B | -1.2594 | |
| 3 | Q | B | -1.2039 | |
| 4 | S | B | -0.2228 | |
| 5 | V | B | 0.7754 | |
| 6 | S | B | -0.0283 | |
| 7 | S | B | 0.0250 | |
| 8 | L | B | -0.5684 | |
| 9 | A | B | -0.5271 | |
| 10 | E | B | -1.2380 | |
| 11 | K | B | -1.0357 | |
| 12 | D | B | 0.0000 | |
| 13 | I | B | -0.8805 | |
| 14 | Q | B | -1.3952 | |
| 15 | Y | B | -0.8943 | |
| 16 | Q | B | 0.0000 | |
| 17 | L | B | 0.0000 | |
| 18 | H | B | 0.0000 | |
| 19 | P | B | 0.0000 | |
| 20 | F | B | 0.0003 | |
| 21 | T | B | 0.0000 | |
| 22 | N | B | 0.0000 | |
| 23 | A | B | 0.0000 | |
| 24 | R | B | -1.3786 | |
| 25 | L | B | -0.4518 | |
| 26 | H | B | 0.0000 | |
| 27 | Q | B | -1.2109 | |
| 28 | E | B | -1.2005 | |
| 29 | L | B | 0.6726 | |
| 30 | G | B | 0.0000 | |
| 31 | P | B | -0.1281 | |
| 32 | L | B | -0.0876 | |
| 33 | I | B | 0.0000 | |
| 34 | I | B | 0.0000 | |
| 35 | E | B | -1.9997 | |
| 36 | R | B | -2.2558 | |
| 37 | G | B | -1.3705 | |
| 38 | Q | B | -1.5237 | |
| 39 | G | B | -0.4711 | |
| 40 | I | B | 0.0000 | |
| 41 | Y | B | -0.3316 | |
| 42 | V | B | 0.0000 | |
| 43 | Y | B | -1.5750 | |
| 44 | D | B | -2.0198 | |
| 45 | D | B | -2.8206 | |
| 46 | Q | B | -2.5038 | |
| 47 | G | B | -2.2458 | |
| 48 | K | B | -2.0022 | |
| 49 | G | B | -1.2737 | |
| 50 | Y | B | 0.0000 | |
| 51 | I | B | 0.0000 | |
| 52 | E | B | 0.0000 | |
| 53 | A | B | 0.0000 | |
| 54 | M | B | 0.0000 | |
| 55 | A | B | 0.0000 | |
| 56 | G | B | 0.0000 | |
| 57 | L | B | 0.1921 | |
| 58 | G | B | 0.0000 | |
| 59 | S | B | 0.0000 | |
| 60 | V | B | 0.0000 | |
| 61 | A | B | 0.0000 | |
| 62 | L | B | 0.0000 | |
| 63 | G | B | 0.0000 | |
| 64 | F | B | 0.0000 | |
| 65 | S | B | -1.3270 | |
| 66 | N | B | -1.5166 | |
| 67 | Q | B | -2.2061 | |
| 68 | R | B | -1.9019 | |
| 69 | L | B | 0.0000 | |
| 70 | I | B | 0.0000 | |
| 71 | K | B | -2.8505 | |
| 72 | A | B | -1.6928 | |
| 73 | A | B | 0.0000 | |
| 74 | E | B | -2.2357 | |
| 75 | Q | B | -2.1808 | |
| 76 | Q | B | -1.4863 | |
| 77 | F | B | 0.0000 | |
| 78 | N | B | -1.9666 | |
| 79 | T | B | -1.5398 | |
| 80 | L | B | 0.0000 | |
| 81 | P | B | 0.0000 | |
| 82 | F | B | 0.0000 | |
| 83 | Y | B | 0.0000 | |
| 84 | H | B | 0.0000 | |
| 85 | L | B | 0.0000 | |
| 86 | A | B | -0.5105 | |
| 87 | N | B | -1.3017 | |
| 88 | H | B | -0.3815 | |
| 89 | K | B | -0.4897 | |
| 90 | S | B | 0.0000 | |
| 91 | H | B | 0.0000 | |
| 92 | R | B | -1.4804 | |
| 93 | P | B | 0.0000 | |
| 94 | S | B | 0.0000 | |
| 95 | I | B | 0.0000 | |
| 96 | E | B | -1.1501 | |
| 97 | L | B | 0.0000 | |
| 98 | A | B | 0.0000 | |
| 99 | E | B | -1.2788 | |
| 100 | K | B | -1.3851 | |
| 101 | L | B | 0.0000 | |
| 102 | I | B | -0.9594 | |
| 103 | E | B | -1.8977 | |
| 104 | M | B | -0.8289 | |
| 105 | A | B | -0.5655 | |
| 106 | P | B | -0.6222 | |
| 107 | V | B | -0.5432 | |
| 108 | P | B | -0.5740 | |
| 109 | M | B | 0.0000 | |
| 110 | S | B | -0.5470 | |
| 111 | K | B | 0.0000 | |
| 112 | V | B | 0.0000 | |
| 113 | F | B | 0.0000 | |
| 114 | F | B | 0.0000 | |
| 115 | T | B | 0.0000 | |
| 116 | N | B | 0.0000 | |
| 117 | S | B | 0.0000 | |
| 118 | G | B | -0.0328 | |
| 119 | S | B | 0.0000 | |
| 120 | E | B | 0.0000 | |
| 121 | A | B | 0.0000 | |
| 122 | N | B | 0.0000 | |
| 123 | D | B | 0.0000 | |
| 124 | T | B | 0.0000 | |
| 125 | V | B | 0.0000 | |
| 126 | V | B | 0.0000 | |
| 127 | K | B | 0.0000 | |
| 128 | F | B | 0.0000 | |
| 129 | V | B | 0.0000 | |
| 130 | W | B | 0.0000 | |
| 131 | Y | B | 0.0000 | |
| 132 | L | B | 0.0000 | |
| 133 | N | B | 0.0000 | |
| 134 | N | B | -1.0450 | |
| 135 | A | B | -0.5098 | |
| 136 | L | B | 0.2115 | |
| 137 | G | B | -0.7165 | |
| 138 | K | B | -1.7718 | |
| 139 | P | B | -1.3696 | |
| 140 | A | B | -1.1460 | |
| 141 | K | B | 0.0000 | |
| 142 | K | B | -1.0546 | |
| 143 | K | B | -0.7344 | |
| 144 | F | B | 0.0000 | |
| 145 | I | B | 0.0000 | |
| 146 | S | B | 0.0000 | |
| 147 | R | B | 0.0000 | |
| 148 | V | B | 0.4788 | |
| 149 | N | B | -0.3281 | |
| 150 | G | B | 0.0000 | |
| 151 | Y | B | 0.2614 | |
| 152 | H | B | 0.0000 | |
| 153 | G | B | 0.0000 | |
| 154 | S | B | 0.0000 | |
| 155 | T | B | 0.0000 | |
| 156 | V | B | 0.0000 | |
| 157 | A | B | 0.0000 | |
| 158 | S | B | 0.0000 | |
| 159 | A | B | 0.0000 | |
| 160 | S | B | 0.0000 | |
| 161 | L | B | 0.0000 | |
| 162 | T | B | 0.0000 | |
| 163 | G | B | 0.0000 | |
| 164 | D | B | -0.7816 | mutated: FD164B |
| 165 | P | B | -0.9431 | |
| 166 | G | B | -0.8356 | |
| 167 | N | B | 0.0000 | |
| 168 | Q | B | -1.3104 | |
| 169 | R | B | -1.7734 | |
| 170 | G | B | -1.2273 | |
| 171 | F | B | 0.0000 | |
| 172 | D | B | -1.8094 | |
| 173 | L | B | 0.0000 | |
| 174 | P | B | -0.6449 | |
| 175 | L | B | -0.3099 | |
| 176 | P | B | -0.2817 | |
| 177 | G | B | -0.4218 | |
| 178 | F | B | 0.0000 | |
| 179 | L | B | -0.0159 | |
| 180 | H | B | 0.0221 | |
| 181 | V | B | 0.0000 | |
| 182 | G | B | 0.0017 | |
| 183 | C | B | 0.0000 | |
| 184 | P | B | 0.0000 | |
| 185 | H | B | 0.0000 | |
| 186 | H | B | -0.3747 | |
| 187 | Y | B | -0.3817 | |
| 188 | R | B | -0.4158 | |
| 189 | F | B | 0.3948 | |
| 190 | A | B | -0.9759 | |
| 191 | D | B | -2.0088 | mutated: LD191B |
| 192 | A | B | -0.9576 | |
| 193 | G | B | -1.2147 | |
| 194 | E | B | -1.5820 | |
| 195 | S | B | -1.7228 | |
| 196 | E | B | -2.0509 | |
| 197 | E | B | -2.3530 | |
| 198 | H | B | -2.7246 | |
| 199 | F | B | 0.0000 | |
| 200 | A | B | 0.0000 | |
| 201 | D | B | -2.1530 | |
| 202 | R | B | -1.8287 | |
| 203 | L | B | 0.0000 | |
| 204 | A | B | 0.0000 | |
| 205 | V | B | 0.0308 | |
| 206 | E | B | -1.0143 | |
| 207 | L | B | 0.0000 | |
| 208 | E | B | -1.1417 | |
| 209 | Q | B | -1.2102 | |
| 210 | K | B | -0.9934 | |
| 211 | I | B | 0.0000 | |
| 212 | L | B | -0.1267 | |
| 213 | A | B | -0.3168 | |
| 214 | E | B | -0.8624 | |
| 215 | G | B | -0.6736 | |
| 216 | P | B | -1.4637 | |
| 217 | E | B | -2.3830 | |
| 218 | T | B | -1.3007 | |
| 219 | I | B | 0.0000 | |
| 220 | A | B | 0.0000 | |
| 221 | A | B | 0.0000 | |
| 222 | F | B | 0.0000 | |
| 223 | I | B | 0.0000 | |
| 224 | G | B | 0.0000 | |
| 225 | E | B | 0.0000 | |
| 226 | P | B | 0.0000 | |
| 227 | L | B | 0.0000 | |
| 228 | M | B | 0.0000 | |
| 229 | G | B | 0.0000 | |
| 230 | A | B | -0.0597 | |
| 231 | G | B | -0.0154 | |
| 232 | G | B | 0.0000 | |
| 233 | A | B | 0.0000 | |
| 234 | I | B | 0.0000 | |
| 235 | V | B | 0.2921 | |
| 236 | P | B | 0.0000 | |
| 237 | P | B | 0.0000 | |
| 238 | R | B | -2.4364 | |
| 239 | T | B | -2.1919 | |
| 240 | Y | B | 0.0000 | |
| 241 | W | B | 0.0000 | |
| 242 | E | B | -2.8637 | |
| 243 | K | B | -2.2248 | |
| 244 | I | B | 0.0000 | |
| 245 | Q | B | -2.5925 | |
| 246 | K | B | -3.4203 | |
| 247 | V | B | 0.0000 | |
| 248 | C | B | 0.0000 | |
| 249 | R | B | -3.7368 | |
| 250 | K | B | -3.5352 | |
| 251 | Y | B | -2.5241 | |
| 252 | D | B | -2.9996 | |
| 253 | I | B | 0.0000 | |
| 254 | L | B | -0.5382 | |
| 255 | V | B | 0.0000 | |
| 256 | I | B | 0.0000 | |
| 257 | A | B | 0.0000 | |
| 258 | D | B | 0.0000 | |
| 259 | E | B | 0.0000 | |
| 260 | V | B | 0.2005 | |
| 261 | M | B | 0.0000 | |
| 262 | C | B | 0.0000 | |
| 263 | G | B | 0.0000 | |
| 264 | F | B | 0.0000 | |
| 265 | G | B | 0.0000 | |
| 266 | R | B | 0.0000 | |
| 267 | T | B | 0.0000 | |
| 268 | G | B | -1.2625 | |
| 269 | Q | B | -1.3791 | |
| 270 | M | B | -0.8802 | |
| 271 | F | B | 0.0000 | |
| 272 | G | B | 0.0000 | |
| 273 | S | B | 0.0000 | |
| 274 | Q | B | -1.1687 | |
| 275 | T | B | -0.5873 | |
| 276 | F | B | -0.8200 | |
| 277 | G | B | -1.2386 | |
| 278 | I | B | 0.0000 | |
| 279 | Q | B | -1.5957 | |
| 280 | P | B | 0.0000 | |
| 281 | D | B | 0.0000 | |
| 282 | I | B | 0.0000 | |
| 283 | M | B | 0.0000 | |
| 284 | V | B | 0.0000 | |
| 285 | L | B | 0.0000 | |
| 286 | S | B | 0.0000 | |
| 287 | K | B | -0.1257 | |
| 288 | Q | B | 0.0000 | |
| 289 | L | B | 0.0000 | |
| 290 | S | B | 0.0000 | |
| 291 | S | B | 0.0000 | |
| 292 | S | B | 0.0000 | |
| 293 | Y | B | 0.0000 | |
| 294 | Q | B | 0.0000 | |
| 295 | P | B | 0.0000 | |
| 296 | I | B | 0.0000 | |
| 297 | A | B | 0.0000 | |
| 298 | A | B | 0.0000 | |
| 299 | I | B | 0.0000 | |
| 300 | L | B | 0.0000 | |
| 301 | I | B | 0.0000 | |
| 302 | N | B | -0.3921 | |
| 303 | A | B | -0.5586 | |
| 304 | P | B | -0.7003 | |
| 305 | V | B | 0.0000 | |
| 306 | F | B | 0.0000 | |
| 307 | E | B | -1.9465 | |
| 308 | G | B | -1.0806 | |
| 309 | I | B | 0.0000 | |
| 310 | A | B | 0.0000 | |
| 311 | D | B | -2.4792 | |
| 312 | Q | B | -1.6189 | |
| 313 | S | B | 0.0000 | |
| 314 | Q | B | -1.7739 | |
| 315 | A | B | -0.9787 | |
| 316 | L | B | -0.8898 | |
| 317 | G | B | -0.8601 | |
| 318 | A | B | -0.7285 | |
| 319 | L | B | 0.0000 | |
| 320 | G | B | 0.0000 | |
| 321 | H | B | 0.0000 | |
| 322 | G | B | 0.0000 | |
| 323 | F | B | 0.0000 | |
| 324 | T | B | -0.0290 | |
| 325 | G | B | -0.0549 | |
| 326 | S | B | 0.0000 | |
| 327 | G | B | 0.0000 | |
| 328 | H | B | 0.0000 | |
| 329 | P | B | 0.0000 | |
| 330 | V | B | 0.0000 | |
| 331 | A | B | 0.0000 | |
| 332 | T | B | 0.0000 | |
| 333 | A | B | -0.5972 | |
| 334 | V | B | 0.0000 | |
| 335 | A | B | 0.0000 | |
| 336 | L | B | -0.3947 | |
| 337 | E | B | -0.7620 | |
| 338 | N | B | 0.0000 | |
| 339 | L | B | 0.0000 | |
| 340 | K | B | -2.3734 | |
| 341 | I | B | 0.0000 | |
| 342 | I | B | 0.0000 | |
| 343 | E | B | -3.7532 | |
| 344 | E | B | -3.8656 | |
| 345 | E | B | -3.6078 | |
| 346 | S | B | -2.9026 | |
| 347 | L | B | 0.0000 | |
| 348 | V | B | -1.7155 | |
| 349 | E | B | -2.7395 | |
| 350 | H | B | -1.8101 | |
| 351 | A | B | 0.0000 | |
| 352 | A | B | -1.5441 | |
| 353 | Q | B | -2.0335 | |
| 354 | M | B | 0.0000 | |
| 355 | G | B | 0.0000 | |
| 356 | Q | B | -1.3804 | |
| 357 | L | B | -0.8072 | |
| 358 | L | B | 0.0000 | |
| 359 | R | B | -1.0155 | |
| 360 | S | B | -0.8762 | |
| 361 | G | B | -0.9554 | |
| 362 | L | B | 0.0000 | |
| 363 | Q | B | -1.3242 | |
| 364 | H | B | -1.4248 | |
| 365 | F | B | -0.7307 | |
| 366 | I | B | -0.6371 | |
| 367 | D | B | -1.8889 | |
| 368 | H | B | -1.0221 | |
| 369 | P | B | -1.2444 | |
| 370 | L | B | 0.0000 | |
| 371 | V | B | 0.0000 | |
| 372 | G | B | -0.6692 | |
| 373 | E | B | -0.5962 | |
| 374 | I | B | -0.1704 | |
| 375 | R | B | -0.1907 | |
| 376 | G | B | -0.1286 | |
| 377 | C | B | -0.1947 | |
| 378 | G | B | 0.0000 | |
| 379 | L | B | 0.0000 | |
| 380 | I | B | 0.0000 | |
| 381 | A | B | 0.0000 | |
| 382 | A | B | 0.0000 | |
| 383 | V | B | 0.0000 | |
| 384 | E | B | 0.0000 | |
| 385 | L | B | 0.0000 | |
| 386 | V | B | 0.0000 | |
| 387 | G | B | -0.7920 | |
| 388 | D | B | -0.9412 | |
| 389 | R | B | -0.9677 | |
| 390 | V | B | 0.8320 | |
| 391 | S | B | -0.1053 | |
| 392 | K | B | -0.7555 | |
| 393 | A | B | -0.3404 | |
| 394 | P | B | -0.1884 | |
| 395 | Y | B | -0.1108 | |
| 396 | Q | B | -0.6938 | |
| 397 | A | B | 0.2612 | |
| 398 | L | B | 1.1133 | |
| 399 | G | B | 0.0000 | |
| 400 | T | B | -0.3212 | |
| 401 | L | B | 0.0000 | |
| 402 | G | B | 0.0000 | |
| 403 | R | B | -1.8039 | |
| 404 | Y | B | -0.9885 | |
| 405 | M | B | 0.0000 | |
| 406 | A | B | -1.3858 | |
| 407 | G | B | -1.6257 | |
| 408 | R | B | -2.4072 | |
| 409 | A | B | 0.0000 | |
| 410 | Q | B | -1.7585 | |
| 411 | E | B | -2.7053 | |
| 412 | H | B | -2.0554 | |
| 413 | G | B | 0.0000 | |
| 414 | M | B | 0.0000 | |
| 415 | I | B | 0.0000 | |
| 416 | T | B | -0.3938 | |
| 417 | D | B | -1.0945 | |
| 418 | A | B | -0.7745 | |
| 419 | M | B | -0.1443 | |
| 420 | G | B | -0.0813 | |
| 421 | D | B | 0.0000 | |
| 422 | A | B | 0.0000 | |
| 423 | V | B | 0.0000 | |
| 424 | A | B | 0.0000 | |
| 425 | F | B | 0.0000 | |
| 426 | C | B | 0.0000 | |
| 427 | P | B | 0.0000 | |
| 428 | P | B | 0.0000 | |
| 429 | L | B | 0.0000 | |
| 430 | I | B | 0.1353 | |
| 431 | V | B | 0.0000 | |
| 432 | N | B | -1.7239 | |
| 433 | E | B | -2.6640 | |
| 434 | Q | B | -2.3559 | |
| 435 | E | B | -1.6625 | |
| 436 | V | B | 0.0000 | |
| 437 | G | B | -1.6106 | |
| 438 | M | B | -1.3391 | |
| 439 | I | B | 0.0000 | |
| 440 | V | B | -1.3414 | |
| 441 | E | B | -2.3217 | |
| 442 | R | B | -2.0494 | |
| 443 | F | B | 0.0000 | |
| 444 | A | B | -2.0294 | |
| 445 | R | B | -3.1926 | |
| 446 | A | B | 0.0000 | |
| 447 | L | B | 0.0000 | |
| 448 | D | B | -3.1508 | |
| 449 | D | B | -2.3275 | |
| 450 | T | B | 0.0000 | |
| 451 | T | B | -2.1076 | |
| 452 | Q | B | -2.2248 | |
| 453 | W | B | -0.8698 | |
| 454 | V | B | -0.7941 | |
| 455 | G | B | -1.5623 | |
| 456 | E | B | -2.4444 |
ALA alanine
ARG arginine
ASN asparagine
ASP aspartic acid
CYS cysteine
GLN glutamine
GLU glutamic acid
GLY glycine
HIS histidine
ILE isoleucine
LEU leucine
LYS lysine
MET methionine
PHE phenylalanine
PRO proline
SER serine
THR threonine
TRP tryptophan
TYR tyrosine
VAL valine